The Role of Preservative-free Therapies in the Treatment of Glaucoma

Baudouin, Christophe; Hommer, Anton; Konstas, Anastasios G. P.; Traverso, Carlo Enrico

doi:10.17925/eor.2013.07.02.74

Cited by 2 publications

(2 citation statements)

References 39 publications

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“…11 It is typically used in concentrations of 0.001% -0.004%. 11 As reported by Baudouin and Traverso, 17 the risk of ocular surface disease is increased greatly by BAK in topical glaucoma medications. Preservative-free treatments such as PF-tafluprost have proved beneficial.…”

Section: Discussionmentioning

confidence: 85%

Medicamentosa keratoconjunctivitis: A case report

Okoro¹,

Amiebenomo

Aruotu

2016

African Vision and Eye Health

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We present a case of medicamentosa keratoconjunctivitis in a 42-year-old woman who complained of eye redness, blurred vision and pain after using inappropriate medications for treatment. Examination revealed severe conjunctival injection as well as punctate stains on the corneas. The patient was advised to stop her former medications and was prescribed an artificial tear supplement, an antibiotic-steroid combination and a topical nonsteroidal anti-inflammatory drug. Possible conditions that could elicit similar clinical features are highlighted. The purpose of the case report is to raise issues relating to drug-induced allergic/sensitivity reactions based on recent clinical and experimental reports and also the roles of active ingredients and preservatives.Keywords: Superficial punctate epitheliopathy; Medicamentosa; Factitious disease; Dry eye syndrome; Benzalkonium chloride

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Section: Discussionmentioning

confidence: 85%

Medicamentosa keratoconjunctivitis: A case report

Okoro¹,

Amiebenomo

Aruotu

2016

African Vision and Eye Health

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“…Current research is mainly focused on the effect that the medications, particularly the preservatives contained herein, may exert on the ocular surface [10,12]. The preservatives, especially benzalkonium chloride, are the main factors impairing the normal state and function of the ocular surface [13][14][15]. Glaucoma represents a heterogeneous group of chronic optic neuropathies, which typically exhibit excavation of the optic nerve head and loss in the visual field [16].…”

Section: Introductionmentioning

confidence: 99%

Objective assessment of ocular surface as an important prognostic factor for dry eye development in patients with glaucoma

Vassilev¹,

Chernodrinska²,

Kostova³

et al. 2018

biomedicalresearch

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Objectives: To investigate and compare the tear volume, tear film stability, Meibomian gland loss of healthy and glaucoma subjects from the Bulgarian population and to assess the relationship between clinical findings and glaucoma therapy. Methods: In this observational cross-sectional study, a random cohort of 68 subjects was enrolled and divided into patients with primary open-angle glaucoma or ocular hypertension (POAG/OHT group; n=19) and healthy controls (HC group; n=49). Ocular surface was analysed objectively by Noninvasive tear Break-Up Time (NIBUT), Meibomian gland loss, and Schirmer test for basal secretion. In addition, Central Corneal Thickness (CCT) was measured with pachymetry. Results: Loss of Meibomian glands (39.85% ± 14.49%), as well as a decrease in Schirmer test values (7.29 mm ± 3.92 mm) and NIBUT (8.26 s ± 4.73 s), were typical in the POAG/OHT group, regardless of disease duration. Significant factors affecting the ocular surface state were age, anti-glaucoma treatment (type and duration), and the presence of preservatives. A worsening of all clinical parameters was evident in the glaucoma patients. A correlation between CCT and NIBUT was established (p=0.037; r=0.167). Conclusions: Local glaucoma treatment affects the ocular surface objective parameters according to its duration and the composition of treatment eye drops.

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The Role of Preservative-free Therapies in the Treatment of Glaucoma

Abstract: The satellite symposium 'Role of Preservative-free Therapies in the Treatment of Glaucoma' at the 2013 annual meeting of the European

Cited by 2 publications

References 39 publications

Medicamentosa keratoconjunctivitis: A case report

Medicamentosa keratoconjunctivitis: A case report

Objective assessment of ocular surface as an important prognostic factor for dry eye development in patients with glaucoma

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