The role of presurgical EEG parameters and of reoperation for seizure outcome in temporal lobe epilepsy

Abstract

Preoperative bilateral ictal foci are a negative predictor for seizure outcome. Contrarily, IED exceeding the affected temporal lobe in the ipsilateral hemisphere or even bilateral IED had favorable seizure outcome if seizure onset is strictly limited to the affected temporal lobe. Reoperation for seizure persistence constitutes a promising therapeutic option.

Epilepsy surgery: Late seizure recurrence after initial complete seizure freedom

“…For information on early relapse in our patient collective, we point to further outcome studies identifying predictive factors for seizure outcome (absence of APOSs and postoperative IEDs, shorter duration of epilepsy, and younger age at surgery). 1,3,4,[32][33][34] PET being performed more often leads to the conclusion that the patients in the relapse group were considered to be more complex or endangered cases. Although not significant in multivariate analysis, higher AED doses and higher number of different AEDs used presurgically support this conclusion.…”

“…Our results and the results of other studies in our patient cohort 1,3,4,32 do not support extratemporal resection as a negative predictor of short‐ and long‐term seizure freedom. For information on early relapse in our patient collective, we point to further outcome studies identifying predictive factors for seizure outcome (absence of APOSs and postoperative IEDs, shorter duration of epilepsy, and younger age at surgery) 1,3,4,32–34 …”

Surgical Treatment of Mri-Negative Epilepsy (A Review)

“…Это обязательное исследование при подготовке пациента с фармакорезистентной эпилепсией к хирургическому лечению [1,9,19]. Цель проведения ЭЭГ -подтвердить эпилептический характер приступа, выявить зону его начала, проследить его электро-графическую и клиническую динамику, сопоставить с симптомами, зафиксированными при синхронном видеомониторинге [29]. Различают скальповую ЭЭГ, при которой регистрирующие электроды помещают на поверхность кожи головы, и инвазивную, при которой электроды располагают на поверхности коры или в глубине вещества головного мозга.…”

Anticonvulsant Effects of Dingxian Pill in Pentylenetetrazol-Kindled Rats

“…On the one hand, the routine antiepileptic drugs focus on reducing the convulsive symptoms with side effects such as cognitive impairment or liver injury [5–8]. On the other hand, 30% of patients, without being improved the pathogenesis after treatment with conventional antiepileptic drugs, still develop into the intractable epilepsy [9–12]. Therefore, it is urgent to explore effective drugs and pharmacological mechanisms for the treatment of epilepsy.…”