The role of pretreatment prognostic nutritional index in esophageal cancer: A meta‐analysis

Xue, Yibo; Zhou, Xiang; Xue, Lijun; Zhou, Ruhua

doi:10.1002/jcp.28565

Cited by 50 publications

(45 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There have numerous articles to use the meta-analysis to confirm the prognostic significance of preoperative serum albumin for patients with urothelial carcinoma, [ 24 ] epithelial ovarian cancer, [ 25 ] bladder cancer [ 26 ] ; AGR for digestive system cancers, [ 27 ] or combined all cancer types [ 28 , 29 ] ; and PNI for lung cancer, [ 30 , 31 ] hepatocellular carcinoma, [ 32 ] esophageal cancer, [ 33 ] and pancreatic cancer. [ 34 ] All these studies revealed the cancer patients with decreased albumin, AGR, and PNI held a worse OS compared with those who carried a higher albumin, AGR, and PNI.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of preoperative serum albumin, albumin-to-globulin ratio, and prognostic nutritional index for patients with glioma

Liu¹,

Wang²

2020

Medicine

View full text Add to dashboard Cite

Background: The serum albumin, albumin-to-globulin ratio (AGR), and prognostic nutritional index (PNI) have been recommended to represent the nutritional and inflammatory status. Thus, they may be potential prognostic biomarkers for cancer. However, contradictory results were reported in different studies on glioma. The goal of this study was to perform a meta-analysis to re-evaluate their prognostic potential for glioma. Methods: Databases of PubMed, EMBASE, and Cochrane Library were systematically searched to enroll all the studies investigating the prognostic significance of albumin, AGR, and PNI for glioma. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using STATA 13.0 software to indicate the intensity of association. Results: Eleven studies with 2928 cases were included. Overall meta-analysis showed that the prognostic values of albumin, AGR, and PNI were limited for glioma ( P > .05). However, subgroup analysis demonstrated a high preoperative serum albumin was significantly related with excellent OS of patients with GBM (HR = 0.95, 95% CI: 0.91–0.99, P = .018), while high PNI (HR = 0.56, 95% CI: 0.43–0.73, P < .001) and AGR (HR = 0.57, 95% CI: 0.34–0.96, P = .034) may be a protective factor of favorable OS for patients with high-grade gliomas. Furthermore, integration of all studies with multivariate analysis and clear cut-off also proved reduced preoperative serum albumin, AGR, and PNI were predictors of poor prognosis for patients with gliomas. Conclusion: Preoperative serum albumin, AGR, and PNI may represent promising biomarkers to predict the prognosis in patients with glioma, especially for high-grade.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic significance of preoperative serum albumin, albumin-to-globulin ratio, and prognostic nutritional index for patients with glioma

Liu¹,

Wang²

2020

Medicine

View full text Add to dashboard Cite

show abstract

“…Several nutritional biomarkers have been shown to have well described relationships with longterm survival (10,(15)(16)(17). The PNI is one of the prognostic biomarkers demonstrated to be associated with prognosis as well as clinicopathological features in EC (21). The investigation of body composition, so called sarcopenia, in EC patients for the purpose of nutritional evaluation may be useful, as sarcopenia has been reported to be significantly associated with worse prognosis after esophagectomy (22).…”

Section: Discussionmentioning

confidence: 99%

Systematic Review on the Controlling Nutritional Status (CONUT) Score in Patients Undergoing Esophagectomy for Esophageal Cancer

et al. 2020

View full text Add to dashboard Cite

Background/Aim: The present study aimed to examine the association of the controlling nutritional status (CONUT) score with outcomes in patients undergoing esophagectomy for esophageal cancer (EC). Materials and Methods: A systematic literature review was carried out to investigate the impact of the CONUT score in EC. Next, metaanalysis of long-term outcomes was performed. Results: The search found six eligible retrospective studies, and five studies with 952 patients were included in the meta-analysis. Metaanalysis found a significant association of the CONUT score with outcomes including overall survival [hazard ratio (HR)=2.51, 95% confidence interval (CI)=1.75-3.60, p<0.001], cancer-specific survival (HR=2.60, 95%CI=1.53-4.41, p<0.001), and recurrence free survival (HR=2.08, 95%CI=1.39-3.12, p<0.001). Conclusion: The CONUT score may be an independent predictor associated with prognosis in patients undergoing esophagectomy for EC. However, further studies are needed to clarify the association of the CONUT score with postoperative outcomes in EC patients. Preoperative nutritional status has recently been highlighted as an important determinant to predict prognosis of cancer (1-3). The controlling nutritional status (CONUT) score is a newly developed system for nutritional screening, which is calculated by three laboratory values: plasma albumin, plasma cholesterol and total lymphocyte count (4). Recently, the association of the CONUT score with outcomes has been demonstrated in the field of surgical oncology (5-9). Since 2016, a few studies reported on the CONUT score in patients undergoing esophagectomy for esophageal cancer (EC) (10, 11). However, most studies included small sample sizes and the prognostic significance of the CONUT score in EC has not been systematically investigated so far. The aim of the present study was to perform a systematic review to summarize the current published evidence regarding the CONUT score in EC. In addition, metaanalyses were carried out to investigate the prognostic significance of the CONUT score in EC. Materials and Methods A systematic review. A systematic literature search was conducted on the 13 th of December 2019 and applied to five databases of Embase, Medline Ovid, Web of Science, Cochrane CENTRAL, and Google scholar, to find out all available articles on the CONUT score and the association with outcome in patients undergoing esophagectomy for EC. The search was limited in English articles with no restrictions on the publication year. This study reports in compliance with the Preferred Reporting Items for Systematic Reviewers and Meta-Analyses (PRISMA) guidelines (12), and is registered with the University Hospital Medical Information Network (UMIN000040112). First, duplicate records were removed. Next, all the title and abstracts were screened to determine the eligible studies. Finally, full-text articles were assessed to meet the inclusion criteria. The following data were extracted: study information (publication year, country of the study, and study design), pa...

show abstract

“…The prognostic nutritional index (PNI) is evaluated using the serum albumin level and the lymphocyte count. Albumin has been reported as a biomarker of the nutritional status, and its level has been identified to be related to the co-morbidities and the prognosis for certain cancers [ 24 , 25 ]. It evaluates the susceptibility to infection by assessing malnutrition associated with insufficient protein intake and the evaluation of biological defense capabilities using tests combining evaluation of visceral protein status and immunological function.…”

Section: Introductionmentioning

confidence: 99%

Prognostic impact of the prognostic nutritional index in cases of resected oral squamous cell carcinoma: a retrospective study

et al. 2021

View full text Add to dashboard Cite

Background The systemic inflammatory response and nutritional status of patients with malignant tumors are related to postoperative results. We examined the usefulness of the prognostic nutritional index (PNI) as a prognostic tool in patients with oral squamous cell carcinoma who underwent radical surgery. Methods From 2008 to 2019, 102 patients (73 males, 29 females; age, 65.6 ± 9.8 years) who visited our hospital and underwent surgical therapy were included in this study. The endpoint was the total survival period, and the evaluation markers included the lymphocyte count and albumin level in peripheral blood obtained 4 weeks preoperatively, age, sex, alcohol consumption, smoking history, site of the tumor, pathological stage, and surgery status. The PNI was calculated using serum albumin levels and the peripheral blood lymphocyte count. The relationship between the PNI and patient characteristics were analyzed using Fisher's exact test. The Kaplan–Meier method was used to evaluate the survival rate. The survival periods were compared using the log-rank method. We evaluated the prognostic factors for overall survival (OS) and disease-free survival (DFS) in a logistic regression model. Results The tumor sites included the maxilla (n = 12), buccal mucosa (n = 11), mandible (n = 17), floor of the mouth (n = 9), and tongue (n = 53). The number of patients with stage I, II, III, and IV oral cancers was 28 (27.5%), 34 (27.5%), 26 (33.3%), and 14 (13.7%), respectively. During the observation period, 21 patients died of head and neck cancer. The optimal cut-off PNI value was 42.9, according to the receiver operating characteristic analysis. The proportion of patients with a short OS was lower in those with PNI higher than 42.9, and the 5-year OS in patients with PNI higher and lower than the cut-off value was 62.3% and 86.0%, respectively (P = 0.0105). Conclusions The OS of patients with PNI < 42.9 was lower than that of patients with PNI ≥ 42.9. The PNI, which is a preoperative head-to-foot inflammatory marker, can help in estimating the prognosis of oral cancer.

show abstract

The role of pretreatment prognostic nutritional index in esophageal cancer: A meta‐analysis

Cited by 50 publications

References 45 publications

Prognostic significance of preoperative serum albumin, albumin-to-globulin ratio, and prognostic nutritional index for patients with glioma

Prognostic significance of preoperative serum albumin, albumin-to-globulin ratio, and prognostic nutritional index for patients with glioma

Systematic Review on the Controlling Nutritional Status (CONUT) Score in Patients Undergoing Esophagectomy for Esophageal Cancer

Prognostic impact of the prognostic nutritional index in cases of resected oral squamous cell carcinoma: a retrospective study

Contact Info

Product

Resources

About