INTRODUCTIONThe study aims to assess the level of burnout among Greek Primary Healthcare Professionals (physicians, nurses, and allied professionals) and to investigate the association between work-related stressors with the presence of clinical burnout. METHODS A multi-center, web-based, cross-sectional survey was conducted from June to end of October 2021, in Greece. Facilitating convenience sampling, the survey recorded demographic data, personal experience with COVID-19, and emerging work-related perspectives and concerns. Burnout was assessed using the Maslach Burnout Inventory (MBI), which is a 22-item inventory, referring to three burnout dimensions: emotional exhaustion (EA, 9 items), depersonalization (DE, 5 items), and personal accomplishment (PA, 8 items). The inventory is rated on a 7-point Likert scale, and, for diagnosis, burnout is experienced when at least 2 of the 3 dimensions yield high scores. Data were analyzed using descriptive statistics and multiple regression models. RESULTS A total of 236 participants, including 104 physicians, 83 nurses, and 49 allied professionals, with a mean age of