2020
DOI: 10.1155/2020/3535982
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The Role of Probiotics in Colorectal Cancer Management

Abstract: Colorectal cancer (CRC) is one of the most common cancerous diseases worldwide and causes leading cancer-associated deaths. Several factors are related to the incidence of CRC such as unhealthy diet and lifestyle, heredity, metabolic disorders, and genetic factors. Even though several advanced medical procedures are available for CRC treatment, the survival rates are poor with many adverse treatments associated side effects, which affects the quality of life. Probiotics are a well-known bioactive candidate for… Show more

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Cited by 84 publications
(59 citation statements)
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References 90 publications
(143 reference statements)
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“…Dysregulation of gut microbiota has been associated with increased inflammation and the administration of probiotics have been reported to prevent chronic inflammatory diseases[ 41 ]. In recent years there has been growing interest in the possible application of probiotics as a part of combination therapy with conventional treatment of cancer[ 41 - 43 ]. However, studies investigating probiotics effects in patients with CRC are still very limited.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Dysregulation of gut microbiota has been associated with increased inflammation and the administration of probiotics have been reported to prevent chronic inflammatory diseases[ 41 ]. In recent years there has been growing interest in the possible application of probiotics as a part of combination therapy with conventional treatment of cancer[ 41 - 43 ]. However, studies investigating probiotics effects in patients with CRC are still very limited.…”
Section: Discussionmentioning
confidence: 99%
“…However, studies investigating probiotics effects in patients with CRC are still very limited. For clinical application in humans many other studies, mainly randomized controlled trials would be needed to better evaluate the dosage, duration of the intervention and host physiology for confirm these findings[ 41 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…However, not all of the probiotic strains possess anti-CRC properties. Hence, further studies are required to identify potent probiotics, as probiotic-based therapeutic agents, to prevent and treat CRC [ 62 ].…”
Section: The Role Of Yeast Probiotics In the Management Of Cancermentioning
confidence: 99%
“…Additionally, another study established that probiotics also have an effect on the production of SCFAs: by modulating the abundance of beneficial flora, they increase the production of butyrate [43]. Due to their effect of increasing SCFAs, probiotics have a unique ability to induce apoptosis and suppress cell proliferation [44]. Overall, these studies lead to the conclusion that probiotics have a bright future as an efficient way to prevent CRC.…”
Section: The Association Between Diet and The Im And Their Role In Thmentioning
confidence: 99%