The Role of Probiotics in Inflammatory Responses of Critically-Ill Burn Patients (A Randomized Clinical Trial)

Putra, Oki Nugraha; Pebrianton, Hengky; Suharjono, Suharjono; Iswinarno, Iswinarno; Rahayu, Dwi Puji

doi:10.2991/hsic-17.2017.61

Cited by 4 publications

(3 citation statements)

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“…Probiotics have been shown to benefit burn patients by regulating the intestinal barrier and reducing inflammation. In contrast to interleukin 6, which is a pro-inflammatory mediator and is frequently produced in burns, Immunoglobulin A (IgA) is an anti-inflammatory antibody [44]. When the intestinal barrier fails and inflammatory mediators enter the systemic circulation via mesenteric lymph channels, they contribute to the development of Multiple Organ Dysfunction Syndrome (MODS) [45].…”

Section: Discussionmentioning

confidence: 99%

Infections in burn patients: Literature review

Hamdar

2023

Open J Clin Med Images

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Section: Discussionmentioning

confidence: 99%

Infections in burn patients: Literature review

Hamdar

2023

Open J Clin Med Images

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“…It seems that the administration of probiotics to burn patients could improve the inflammatory parameters, according to a study performed by Putra et al [ 37 ]. A double-blind, randomized close-label study was conducted on 23 critically burn patients, separated into two groups, both of which were treated once a day, for 14 days, with monostrain probiotics that contained 10 7 CFU (colony forming units) of either L. acidophilus or Bifidobacterium longum ; or multistrain probiotics, including four strains of Lactobacillus ( L. rhamnosus , L. delbrueckii subsp.…”

Section: Types Of Probiotics In Wound Healingmentioning

confidence: 99%

Probiotics in Wound Healing

Bădăluță,

Curuțiu,

Dițu

et al. 2024

IJMS

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Wound infections caused by opportunistic bacteria promote persistent infection and represent the main cause of delayed healing. Probiotics are acknowledged for their beneficial effects on the human body and could be utilized in the management of various diseases. They also possess the capacity to accelerate wound healing, due to their remarkable anti-pathogenic, antibiofilm, and immunomodulatory effects. Oral and topical probiotic formulations have shown promising openings in the field of dermatology, and there are various in vitro and in vivo models focusing on their healing mechanisms. Wound dressings embedded with prebiotics and probiotics are now prime candidates for designing wound healing therapeutic approaches to combat infections and to promote the healing process. The aim of this review is to conduct an extensive scientific literature review regarding the efficacy of oral and topical probiotics in wound management, as well as the potential of wound dressing embedding pre- and probiotics in stimulating the wound healing process.

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“…6,9 Probiotics consist of live microorganisms helping host's intestinal immune system against bacterial expansion specifically through functional improvement of Tol-like receptor 2(TLR2), activiation of intestinal epithelial cells, qualification of phagocytosis, and production of specific antibodies in plasma. [9][10][11][12] Probiotics consist of live microorganisms helping the host's intestinal immune system against bacterial expansion, specifically through the functional improvement of Tol-like receptor 2(TLR2), activation of intestinal epithelial cells, qualification of phagocytosis, and production of specific antibodies in plasma. 13 The main strains of probiotics include Lactobacillus Acidophilus, Lactobacillus casei, and some species of bifidobacterium colonizing in human's small intestine and inhibiting the growth of pathogenic microorganisms through the production of organic acids, cytokines, and bacteriocidal factors.…”

Section: Introductionmentioning

confidence: 99%

Effect of probiotic administration in inflammatory responses of thermal burns

et al. 2023

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Objectives & Introduction It is possible to damage the natural intestinal barrier following severe burn injuries. Oral probiotics' positive effects on the innate immune system or intestinal epithelial layer are proven. This research aimed to evaluate the role of probiotics on plasma inflammatory changes and bacterial colonization in the burned wound after high-grade thermal trauma. Methods This double-blinded randomized controlled trial was conducted on 80 patients with a total body surface area of 20–70%. Patients were allocated to two groups based on four blocks randomization model. Intervention and control groups received daily LactoCare and placebo capsules for 14 consecutive days. Obtaining demographic data, burn and gastrointestinal symptoms were registered by filling out a questionnaire. Additionally, measuring plasma levels of highly sensitive C-reactive protein(hs-CRP), IgA, absolute neutrophilic, and lymphocytic count were performed cumulatively four times prior to and after the intervention. Results Considering eligible data, following the study period analysis showed significant mitigation of inflammatory status in probiotic receivers. The hs-CRP reduced following probiotic (21.38 ± 44.45) consumption compared with placebo (−36.36 ± 79.03) intake ( p < 0.001). Also, the plasma level of IgA significantly decreased in the intervention group (0.88 ± 0.65) than in the control group (0.79 ± 0.18) ( p < 0.001). Wound cultures showed no significant difference between groups, although the incidence rate of bacterial colonization was slightly lower after using probiotics ( p = 0.159). Regarding wound healing, data illustrated that probiotics could accelerate wound healing after 14 days of regular consumption ( p < 0.001). Conclusion Probiotics have advantages for the mitigation of inflammation and wound healing following severe thermal burn injuries. Trends toward Improvement Immune system by increasing IgA level and lymphocytic count and possible Reduction of wound area with exogenous probiotic administration in patients with burns suggest that further investigation in larger sample size is necessary to corroborate our initial, promising findings.

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The Role of Probiotics in Inflammatory Responses of Critically-Ill Burn Patients (A Randomized Clinical Trial)

Abstract: Background: Impairment of intestinal barrier function and increased translocation of bacteria to the

Cited by 4 publications

References 21 publications

Infections in burn patients: Literature review

Infections in burn patients: Literature review

Probiotics in Wound Healing

Effect of probiotic administration in inflammatory responses of thermal burns

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