The role of progenitor endothelial cell dysfunction in arterial hypertension

Abstract

Hypertension remains leading cardiovascular (CV) risk factors in different population worldwide. The negative effect of hypertension on survival and CV complication partly associates with endothelial dysfunction. Recent studies have shown strong linear relation between endothelial dysfunction and morbidity and mortality in hypertensive patients. However, clear innate mechanisms contributing to target organ damages through abnormalities of vascular function are not completely understood. The lowered number and weak function of circulating endothelial progenitor cells (EPCs) is recognized new marker of endothelial dysfunction with high likely predictive value in patient populations with hypertension. The short communication is depicted the uncertain role of EPC dysfunction in pathogenesis of hypertension