2024
DOI: 10.1042/bst20240094
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The role of prokaryotic argonautes in resistance to type II topoisomerases poison ciprofloxacin

Alina Galivondzhyan,
Dmitry Sutormin,
Vladimir Panteleev
et al.

Abstract: Argonaute proteins are programmable nucleases found in all domains of life. Eukaryotic argonautes (eAgos) participate in genetic regulation, antiviral response, and transposon silencing during RNA interference. Prokaryotic argonautes (pAgos) are much more diverse than eAgos and have been implicated in defense against invading genetic elements. Recently, it was shown that pAgos protect bacterial cells from a topoisomerase poison ciprofloxacin, raising a possibility that they may play a role in DNA replication a… Show more

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