1993
DOI: 10.1093/carcin/14.7.1297
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The role of prostaglandin H synthase-mediated metabolism in the induction of oxidative DNA damage by BHA metabolites

Abstract: The carcinogenicity of the phenolic food antioxidant butylated hydroxyanisole may be related to its oxidative biotransformation in vivo. In order to determine the ability of BHA, 2-tert-butyl(1,4)hydroquinone (TBHQ) and 2-tert-butyl(1,4)paraquinone (TBQ) to induce oxidative DNA damage, biological inactivation of single-stranded bacteriophage phi X-174 DNA, as well as induction of 7-hydro-8-oxo-2'-deoxyguanosine (8-oxodG) in dG by these compounds was studied in vitro, in the presence and absence of peroxidases.… Show more

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Cited by 30 publications
(13 citation statements)
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“…DNA concentration was assayed spectrophotometrically. The DNA was digested to deoxynucleosides by treatment with nuclease P1 (25 U/mg DNA) and alkaline phosphatase (25 U/mg DNA) (40).…”
Section: Dna Extraction and Digestionmentioning
confidence: 99%
“…DNA concentration was assayed spectrophotometrically. The DNA was digested to deoxynucleosides by treatment with nuclease P1 (25 U/mg DNA) and alkaline phosphatase (25 U/mg DNA) (40).…”
Section: Dna Extraction and Digestionmentioning
confidence: 99%
“…We used tert-butylhydroquinone (t-BHQ), an inducer of reactive oxygen species 30 and of the antioxidant response. 31,32 Second, cultures grown in a defined medium minimize heterogeneity due to differences in lifestyle, environmental, or dietary background of the donors. Third, fibroblasts have been successfully used to reveal anomalies that are relevant for brain physiopathology in other neurological diseases.…”
Section: Introductionmentioning
confidence: 99%
“…Stimulation of prostaglandin-H synthase and monooxygenase activity [common toxic effects observed in experimental toxicology (Degen, 1993;Schilderman et al, 1993)] can result in a decreased dopamine level (according to the current understanding of dopamine metabolism).…”
Section: Resultsmentioning
confidence: 99%
“…Autoimmune processes (Revillard, 1991) 6. Stimulation of prostaglandin-H synthase and monooxygenase activity (Degen, 1993;Schilderman et al, 1993) 7. Depletion of glutathione (Tazhibaev and Tishchenko, 1992) 8.…”
Section: Resultsmentioning
confidence: 99%