The role of prostaglandins in altered leukocyte function in multiple sclerosis

Dore‐Duffy, Paula; Ho, Shih Yieh; Longo, Michael J.

doi:10.1007/bf00197302

Cited by 10 publications

(2 citation statements)

References 108 publications

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“…We detected both positive and negative regulation of several genes associated with prostaglandin production and binding. Prostaglandins seem to be important in mediating and regulating actions of peripheral inflammatory cells in MS [180]. Our cultures contain only endogenous glial cells, although microglia developmentally arise from monocytes.…”

Section: Prostaglandin Pathways and Mast Cellsmentioning

confidence: 99%

Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for immune-related molecules by central nervous system mixed glial cell cultures

et al. 2006

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Cytokines secreted within the central nervous system (CNS) are important in the development of multiple sclerosis (MS) lesions. The balance between Th1, monocyte/macrophage (M/M) and Th2 cytokines in the CNS may be pivotal in determining the outcome of lesion development. We examined the effects of mixtures of cytokines on gene expression by CNS glial cells, as mixtures of cytokines are present in MS lesions, which in turn contain mixtures of glial cells. In this initial analysis by gene array, we examined changes at 6 hours to identify early changes in gene expression that represent primary responses to the cytokines. Rat glial cells were incubated with mixtures of Th1, M/M and Th2 cytokines for 6 hours and examined for changes in early gene expression employing microarray gene chip technology. A minimum of 814 genes were differentially regulated by one or more of the cytokine mixtures in comparison to controls, including changes in expression in a large number of genes for immune system-related proteins. Expression of the proteins for these genes likely influences development and inhibition of MS lesions as well as protective and regenerative processes. Analysing gene expression for the effects of various combinations of exogenous cytokines on glial cells in the absence of the confounding effects of inflammatory cells themselves should increase our understanding of cytokine-induced pathways in the CNS.

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Section: Prostaglandin Pathways and Mast Cellsmentioning

confidence: 99%

Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for immune-related molecules by central nervous system mixed glial cell cultures

et al. 2006

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“…The depression of an tibody biosynthesis by treatment with piroxicam is in agreement with the observations of Goodwin [9], who performed in vitro experiments with peripheral blood mononuclear cells. But there are many ambiguous re sults which indicate that in vivo PGs can both en hance and suppress humoral immunity [7].…”

Section: Discussionmentioning

confidence: 99%

Protection against Experimental Allergic Encephalomyelitis with Complete Freund’s Adjuvant Is Unaffected by Prostaglandin Synthesis Inhibition

Weber

Hempel²

1989

Int Arch Allergy Immunol

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Pretreatment with complete Freund’s adjuvant blended with aluminium hydroxide (ALU-CFA) prevents the clinical as well as histological manifestation of experimental allergic encephalomyelitis (EAE) in Lewis rats. Suppression of prostaglandin biosynthesis with the cyclooxygenase inhibitor piroxicam (10 mg/kg body weight) from day 2 before to day 17 after EAE induction could not restore responsiveness in pretreated animals. In contrast piroxicam increased ALU-CFA-induced suppression of autoantibodies against myelin basic protein. In controls not pretreated with ALU-CFA, clinical signs of EAE were attenuated by piroxicam, whereas mononuclear infiltration of the brain remained unchanged. Therefore it is unlikely that prostaglandins exert an important function in the regulation of immune responses in this model of autoimmunity.

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Cytokine Secretion by Multiple Sclerosis Monocytes

Rudick

Ransohoff²

1992

Arch Neurol

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The role of prostaglandins in altered leukocyte function in multiple sclerosis

Cited by 10 publications

References 108 publications

Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for immune-related molecules by central nervous system mixed glial cell cultures

Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for immune-related molecules by central nervous system mixed glial cell cultures

Protection against Experimental Allergic Encephalomyelitis with Complete Freund’s Adjuvant Is Unaffected by Prostaglandin Synthesis Inhibition

Cytokine Secretion by Multiple Sclerosis Monocytes

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