The role of PSMA radioligands in the diagnosis and treatment of prostate carcinoma

Rodríguez‐Fraile, Macarena; Alonso, Pilar; Rosales, Juan J.; Arcocha-Torres, M. de; Caresia-Aróztegui, A.P.; Cózar-Santiago, M.P.; Orcajo-Rincón, J.; Perdigó, M. Simó; Bolton, Roberto C. Delgado; Artigas, Carlos

doi:10.1016/j.remnie.2022.02.001

Cited by 2 publications

(1 citation statement)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PSMA expression is upregulated in higher tumor grades and in the development of castration resistance (107). The use of PSMA radioligand in diagnosing and treating PCa has been under studied (108)(109)(110). However, the expression of PSMA in PCa biopsies is highly variable both within one patient and between different patients, which restricts the application of PSMA scans and PSMA-targeted therapies (111).…”

Section: Proteins Involved In Ar-independent Pathwaysmentioning

confidence: 99%

Emerging proteins involved in castration‑resistant prostate cancer via the AR‑dependent and AR‑independent pathways (Review)

Feng,

Liu,

Wang

et al. 2023

Int J Oncol

View full text Add to dashboard Cite

Despite achieving optimal initial responses to androgen deprivation therapy, most patients with prostate cancer eventually progress to a poor prognosis state known as castration-resistant prostate cancer (CRPC). Currently, there is a notable absence of reliable early warning biomarkers and effective treatment strategies for these patients. Although androgen receptor (AR)-independent pathways have been discovered and acknowledged in recent years, the AR signaling pathway continues to play a pivotal role in the progression of CRPC.The present review focuses on newly identified proteins within human CRPC tissues. These proteins encompass both those involved in AR-dependent and AR-independent pathways. Specifically, the present review provides an in-depth summary and analysis of the emerging proteins within AR bypass pathways. Furthermore, the significance of these proteins as potential biomarkers and therapeutic targets for treating CRPC is discussed. Therefore, the present review offers valuable theoretical insights and clinical perspectives to comprehensively enhance the understanding of CRPC.

show abstract