The role of psychosis and clozapine load in excessive checking in treatment-resistant schizophrenia: longitudinal observational study
Emilio Fernandez-Egea,
Shanquan Chen,
Estela Sangüesa
et al.
Abstract:BackgroundA significant proportion of people with clozapine-treated schizophrenia develop ‘checking’ compulsions, a phenomenon yet to be understood.AimsTo use habit formation models developed in cognitive neuroscience to investigate the dynamic interplay between psychosis, clozapine dose and obsessive–compulsive symptoms (OCS).MethodUsing the anonymised electronic records of a cohort of clozapine-treated patients, including longitudinal assessments of OCS and psychosis, we performed longitudinal multi-level me… Show more
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