The role of pulmonary hypertension in the pathogenesis of bronchial asthma

Rosival, Viktor

doi:10.1016/0306-9877(90)90076-q

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…Asthma mortality seems to be declining worldwide (Ebmeier et al, 2017), and it is estimated that in 2015, over 400,000 deaths occurred due to asthma complications (Soriano et al, 2017). Asthma is also associated with other comorbidities, including SAH (Ferguson et al, 2014) and pulmonary hypertension (Rosival, 1990), which are two established risk factors for COVID-19 (Zhang et al, 2020). Other characteristics associated with the worst asthma symptoms, such as obesity and old age, are also associated with poor COVID-19 prognoses (Schatz et al, 2014;Skloot et al, 2016;Płusa, 2017;Zhang et al, 2020).…”

Section: Asthmamentioning

confidence: 99%

The Possible Dual Role of the ACE2 Receptor in Asthma and Coronavirus (SARS-CoV2) Infection

Branco

Sato

Alberca

2020

Front. Cell. Infect. Microbiol.

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Section: Asthmamentioning

confidence: 99%

The Possible Dual Role of the ACE2 Receptor in Asthma and Coronavirus (SARS-CoV2) Infection

Branco

Sato

Alberca

2020

Front. Cell. Infect. Microbiol.

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“…Published reports showed that, in asthmatic lungs, the pulmonary artery inflammation (6,7) and remodeling (8) are connected with increased pulmonary pressure (9) and pulmonary artery hyper responsiveness (10). On the other hand, the role of the renin angiotensin system (RAS) on alteration of reactivity, inflammation and remodeling of blood vessels is well documented (11).…”

Section: Introductionmentioning

confidence: 99%

Ghrelin effects on local renin angiotensin from pulmonary vessels

Vata¹

2010

Acta Endo (Buc)

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Background. Published data sustain the participation of vascular renin angiotensin system (RAS) on alteration of pulmonary vessels reactivity during the allergic airway inflammation. Ghrelin is a growth hormone-releasing peptide involved in modulation of immune function.Objective. This study aims to investigate the interaction between ghrelin and local RAS from rat pulmonary vessels during ovalbumin -induced allergic airway disease.Methods. The angiotensinogen (AGT) -induced contractions were assessed on isolated pulmonary artery and veins from ovalbumin sensitized rats receiving either saline (OSR) or ghrelin (OSG) by endotracheal instillation. Experiments were performed in the absence or the presence of losartan, D-ALA 7 , chymostatin and N ω -nitro-L-arginine methyl ester (L-NAME).Results. The angiotensinogen (AGT) contractile effects mediated by AT1 receptors were lower with at least 25% on vessels from OSG than from OSR. The D-ALA 7 and L-NAME significantly increases the AGT -induced contraction on OSG. The amount of nitric oxide released after stimulation with angiotensinogen (AGT) is higher on OSG and it is blocked by D-ALA 7 .Conclusion. Our results suggested that pulmonary delivery of ghrelin could modulate the local RAS from pulmonary vessels, probably by promoting the angiotensin 1-7 mediated effects. These data sustained the existence of another possible way for ghrelin's beneficial effects on the lung.

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