The role of quantitative bias analysis for nonrandomized comparisons in health technology assessment: recommendations from an expert workshop
Thomas P. Leahy,
Isabelle Durand-Zaleski,
Laura Sampietro-Colom
et al.
Abstract:The use of treatment effects derived from nonrandomized studies (NRS) in health technology assessment (HTA) is growing. NRS carry an inherently greater risk of bias than randomized controlled trials (RCTs). Although bias can be mitigated to some extent through appropriate approaches to study design and analysis, concerns around data availability and quality and the absence of randomization mean residual biases typically render the interpretation of NRS challenging. Quantitative bias analysis (QBA) methods are … Show more
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