The Role of Race, Sex, and Age in Circadian Disruption and Metabolic Disorders

Zhang, Clark; Tait, Christopher; Minacapelli, Carlos D.; Bhurwal, Abhishek; Gupta, Kapil; Amin, Rajan N.; Rustgi, Vinod K.

doi:10.1016/j.gastha.2022.02.015

Cited by 8 publications

(7 citation statements)

References 83 publications

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“…Insufficient sleep or circadian alteration can trigger a decrease in cognitive function and mental performance [22], psychiatric morbidity [23], physical fatigue, decreased levels of attention and concentration, increased risk of accidents, slow complex coordination and a weakening of the cardiovascular autonomic response system [24]. Female nurses are also at higher risk of metabolic disorders and disrupted circadian rhythms, which can lead to diseases such as diabetes mellitus, obesity and important cardiovascular diseases, such as coronary artery disease or hypertension [25].…”

Section: Introductionmentioning

confidence: 99%

Relation between Burnout and Sleep Problems in Nurses: A Systematic Review with Meta-Analysis

et al. 2022

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Burnout can affect nurses’ sleep quality. The aim of this study was to analyze the relationship between burnout syndrome and sleep problems in nurses. A systematic review with meta-analysis was performed. PubMed, CINAHL and Scopus databases were used. Some of the inclusion criteria were quantitative studies, in which the levels of burnout and sleep disorders were investigated in a sample of nurses using validated scales. A total of 12 studies were included. Sociodemographic variables did not influence the relation between burnout and sleep problems, except for being female. The environment and workplace violence, together with psychological traits and shifts, affect the probability of developing burnout and insomnia. The meta-analysis sample was n = 1127 nurses. The effect size of the correlation between burnout and sleep disorders was r = 0.39 (95% CI 0.29–0.48) with p < 0.001, indicating that the higher the level of burnout in nurses, the greater the presence of sleep disorders. The positive correlation between burnout and sleep disorders is a problem that must be addressed to improve the health of nurses. Developing turnicity strategies, using warmer lights in hospital units during night shifts and eliminating the fixed night shift could improve nurses’ working conditions.

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Section: Introductionmentioning

confidence: 99%

Relation between Burnout and Sleep Problems in Nurses: A Systematic Review with Meta-Analysis

et al. 2022

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“…Like this, the alteration of diurnal oscillations by shift works, promoted a higher disturbance in the energy homeostasis processes in women compared to men. 16,17 Another similar study in shift workers showed increased proinflammatory gut bacteria in women in comparison with men, may leading to higher rates of obesity. 16,17 Furthermore, in a mice study, Pérez-Mendoza et al 18 reported that hepatic BMAL1 expression was more altered in high fat diet-fed (HFD) female mice than in male mice, impacting differently on lipid metabolism.…”

Section: Introductionmentioning

confidence: 98%

Administration time effect of dietary proanthocyanidins on the metabolome of Fischer 344 rats is sex- and diet-dependent

et al. 2023

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“…Compared to men, women tend to have an earlier chronotype (i.e., the preference to be awake in the morning versus the evening) 8,9 . In addition, sleep problems in women significantly increase during menopause, suggesting involvement of sex hormones in sleep regulation 8 . Studies in rodents have shown that depletion of sex hormones before menopause or hormonal replacement therapy after menopause affects voluntary physical activity and sleep rhythms 10,11 .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…8,9 In addition, sleep problems in women significantly increase during menopause, suggesting involvement of sex hormones in sleep regulation. 8 Studies in rodents have shown that depletion of sex hormones before menopause or hormonal replacement therapy after menopause affects voluntary physical activity and sleep rhythms. 10,11 Whether CD also has sex-dependent effects on energy metabolism and cardiometabolic disease risk remains largely unknown.…”

Section: Introductionmentioning

confidence: 99%

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Circadian disruption impairs glucose homeostasis in male but not in female mice and is dependent on gonadal sex hormones

et al. 2023

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Circadian disruption (CD) is the consequence of a mismatch between endogenous circadian rhythms and behavior, and frequently occurs in shift workers. CD has often been linked to impairment of glucose and lipid homeostasis. It is, however, unknown if these effects are sex dependent. Here, we subjected male and female C57BL/6J mice to 6-h light phase advancements every 3 days to induce CD and assessed glucose and lipid homeostasis. Within this model, we studied the involvement of gonadal sex hormones by injecting mice with gonadotropinreleasing hormone-antagonist degarelix. We demonstrate that CD has sex-specific effects on glucose homeostasis, as CD elevated fasting insulin levels in male mice while increasing fasting glucose levels in female mice, which appeared to be independent of behavior, food intake, and energy expenditure. Absence of gonadal sex hormones lowered plasma insulin levels in male mice subjected to CD while it delayed glucose clearance in female mice subjected to CD. CD elevated plasma triglyceride (TG) levels and delayed plasma clearance of TG-rich lipoproteins in both sexes, coinciding with reduced TG-derived FA uptake by adipose tissues. Absence of gonadal sex hormones did not notably alter the effects of CD on lipid metabolism. We conclude that CD causes sex-dependent effects on glucose metabolism, as aggravated by male gonadal sex hormones and partly rescued by female gonadal sex hormones. Future studies on CD should consider the inclusion of both sexes, which may eventually contribute to personalized advice for shift workers.

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The Role of Race, Sex, and Age in Circadian Disruption and Metabolic Disorders

Cited by 8 publications

References 83 publications

Relation between Burnout and Sleep Problems in Nurses: A Systematic Review with Meta-Analysis

Relation between Burnout and Sleep Problems in Nurses: A Systematic Review with Meta-Analysis

Administration time effect of dietary proanthocyanidins on the metabolome of Fischer 344 rats is sex- and diet-dependent

Circadian disruption impairs glucose homeostasis in male but not in female mice and is dependent on gonadal sex hormones

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