The Role of Radiation Therapy in Pediatric Mucoepidermoid Carcinomas of the Salivary Glands

Thariat, Juliette; Védrine, Pierre-Olivier; Temam, Stéphane; Ali, Ali M.; Orbach, Daniel; Odin, Guillaume; Makeïeff, M.; Nicollas, R.; Penicaud, Martin; Toussaint, B.; Vergez, S.; Laprie, Anne; Rives, M.; Montagne, Karine; Teissier, Natacha; Castillo, L.

doi:10.1016/j.jpeds.2012.09.045

Cited by 38 publications

(65 citation statements)

References 21 publications

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“…19 It accounts for 49% of pediatric and 24% of adult salivary gland carcinomas. 20 Previous case reports have described mucoepidermoid carcinoma of the lung, breast, penis, liver, and thymus, however, very few tumors originating in the pancreas have been documented in the literature. [21][22][23][24][25] In mucoepidermoid carcinomas of the major salivary glands, several grading systems have been proposed to help stratify disease-specific and recurrence-free survival.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Cutaneous Metastasis of a Mucoepidermoid Carcinoma of the Pancreas: First Reported Case

Pandey

Al‐Rohil

Goldstein³

et al. 2016

The American Journal of Dermatopathology

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Section: Discussion/conclusionmentioning

confidence: 99%

Cutaneous Metastasis of a Mucoepidermoid Carcinoma of the Pancreas: First Reported Case

Pandey

Al‐Rohil

Goldstein³

et al. 2016

The American Journal of Dermatopathology

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“…Postoperative radiotherapy may be indicated for patients with adverse histological features or recurrent disease [6,31,33,36] . Radiation therapy for the neck should be considered on a case-bycase basis for pN+ necks.…”

Section: Postoperative Radiotherapymentioning

confidence: 99%

“…Extracapsular spread or involvement of more than 3 nodes are solid indications. In other cases, irradiation volumes should be limited to the primary site for high-grade tumours, given the potential long-term side effects of radiation in children [6,33,35,36] .…”

Section: Postoperative Radiotherapymentioning

confidence: 99%

Salivary Gland Neoplasms in Children and Adolescents

Bradley

Eisele

2016

Salivary Gland Neoplasms

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Salivary gland neoplasms (SGNs) in children are uncommon. Epithelial SGNs (ESGNs) comprise the majority (95%), with the remaining being mesenchymal SGNs (MeSGNs). Pleomorphic adenoma is the most frequently encountered benign neoplasm, mucoepidermoid carcinoma is the most frequent malignant ESGN, and rhabdomyosarcoma is the most frequent malignant MeSGN. ESGN presents in the second decade, whereas MeSGN presents in the first and second decades. Swelling without pain or neurological signs is the main presentation of both benign and malignant neoplasms. Making an accurate preoperative histological diagnosis is important, so a needle biopsy or a perioperative frozen section is useful when there is doubt about the disease status of the patient; the excised tumour margin is also important. Surgical excision should aim to achieve clear margin excision in benign and malignant ESGNs, minimising the need for adjuvant radiotherapy and maximising the long-term likelihood of patient cure. Benign ESGNs are uncommon, and excision is curative, whereas malignant ESGN and MeSGN should be managed by a multidisciplinary paediatric oncology team.

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“…Salivary gland tumors are rare in children, with an estimated annual incidence of 0.8 per million [1, 2]. About half of such tumors are malignant [2–4], and most are well to moderately differentiated without nodal involvement or distant metastasis [5, 6].…”

Section: Introductionmentioning

confidence: 99%

“…About half of such tumors are malignant [2–4], and most are well to moderately differentiated without nodal involvement or distant metastasis [5, 6]. The 5–year survival rates for pediatric patients with malignant salivary gland tumors range from 85% to 98% [1, 6, 7]. …”

Section: Introductionmentioning

confidence: 99%

Proton versus conventional radiotherapy for pediatric salivary gland tumors: Acute toxicity and dosimetric characteristics

Grant

Grosshans

Bilton

et al. 2015

Radiotherapy and Oncology

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Purpose We evaluated acute toxicity profiles and dosimetric data for children with salivary gland tumors treated with adjuvant photon/electron-based radiation therapy (X/E RT) or proton therapy (PRT). Methods and Materials We identified 24 patients who had received adjuvant radiotherapy for salivary gland tumors. Data was extracted from the medical records and the treatment planning systems. Toxicity was scored according to the Common Terminology Criteria for Adverse Effects 4.0. Results Eleven patients received X/E RT and 13 PRT, with a median prescribed dose of 60 Gy in each group. In the X/E RT group, 54% of patients developed acute grade II/III dermatitis, 27% grade II/III dysphagia, and 91% grade II/III mucositis, and the median weight loss was 5.3% with one patient requiring feeding tube placement. In the PRT group, 53% had acute grade II/III dermatitis, 0% grade II/III dysphagia, and 46% grade II/III mucositis, with a median weight gain of 1.2%. Additionally, PRT was associated with lower mean doses to several normal surrounding midline and contralateral structures. Conclusion In this retrospective study of pediatric salivary tumors, PRT was associated with a favorable acute toxicity and dosimetric profile. Continued follow-up is needed to identify long-term toxicity and survival data.

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The Role of Radiation Therapy in Pediatric Mucoepidermoid Carcinomas of the Salivary Glands

Cited by 38 publications

References 21 publications

Cutaneous Metastasis of a Mucoepidermoid Carcinoma of the Pancreas: First Reported Case

Cutaneous Metastasis of a Mucoepidermoid Carcinoma of the Pancreas: First Reported Case

Salivary Gland Neoplasms in Children and Adolescents

Proton versus conventional radiotherapy for pediatric salivary gland tumors: Acute toxicity and dosimetric characteristics

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