The Role of RANKL and Involvement of Cementum in Orthodontic Root Resorption

Yamaguchi, Masaru; Mishima, Hiroyuki

doi:10.3390/app11167244

Cited by 5 publications

(4 citation statements)

References 45 publications

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“…Animal studies have proved the communication of RANKL in periodontal tissues during rat experimental tooth movement, and that the extent of experimental tooth movement in rats was accelerated by the transfer of the RANKL genes, and repressed by the transmission of the OPG gene, to the periodontal tissue. RANKL and OPG levels in GCF are increased and decreased, correspondingly, during OTM [26] .…”

Section: Role Of Rankl/rank/opg In Orthodontic Tooth Movementmentioning

confidence: 95%

RANK-RANKL-OPG: A current trends in orthodontic tooth movement and its role in accelerated orthodontics

Kumar¹,

Raghunath²,

Cha³

2022

Int. J. Appl. Dent. Sci.

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RANKL is a type II membrane protein bearing close homology to TNFSF members TRAIL, FasL, and TNF-a. RANKL has been definite for its key characteristic role in bone metabolism and the immune system. It is an apoptosis regulator gene, a binding partner of osteoprotegerin OPG, a ligand for the receptor RANK, and it controls cell proliferation by modifying protein levels. Osteoblasts and stromal stem cells receptor activator of NFκ-B ligand (RANKL), binds to receptor and RANK, is apparent on the surface of osteoclasts and their predecessors. Osteoprotegerin (OPG) secreted by osteoblasts and osteogenic stromal stem cells keep the skeleton from extreme bone resorption by binding to RANKL and averting it from interacting with RANK osteocytes. The critical cause of RANKL in alveolar bone remodelling during orthodontic tooth movement. The RANKL/OPG proportion in bone marrow is thus a significant element of bone mass in normal and disease conditions. This article reviews the role of the RANKL/RANK/OPG system in bone and other tissues in Orthodontic tooth movement.

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Section: Role Of Rankl/rank/opg In Orthodontic Tooth Movementmentioning

confidence: 95%

RANK-RANKL-OPG: A current trends in orthodontic tooth movement and its role in accelerated orthodontics

Kumar¹,

Raghunath²,

Cha³

2022

Int. J. Appl. Dent. Sci.

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“…Osteoblasts are found on the bone surface, and when stimulated by vitamin D and parathormone (PTH), they can release macrophage colony stimulating factor (M-CSF). This M-CSF has the particularity of differentiating stem cells into osteoclast precursor cells; in turn, if PTH continues its stimulus on osteoblasts, these will release RANK-L in the different processes of bone remodeling [ 17 ].…”

Section: Osteoprotegerin (Opg)mentioning

confidence: 99%

Biology and Mechanobiology of the Tooth Movement during the Orthodontic Treatment

Roossevelt Ramos Montiel,

Puebla Ramos,

Oscar Palmas

et al. 2024

Dentistry

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Orthodontic treatment usually lasts from 2 to 3 years and some intractable cases may require even longer, so the duration of treatment not only leaves the patient dissatisfied, but is also the main reason why many patients reject or refuse orthodontic treatment; Therefore, various areas of research, hand in hand with the needs of orthodontists, have been developing methods to accelerate tooth movement and reduce the duration of orthodontic treatment, in such a context, the biology of tooth movement is a fascinating field of study that focuses on understanding the biological and biomechanical processes involved in tooth movement; thus, through research and scientific advances, it has been possible to obtain greater knowledge about this phenomenon and its application in clinical practice through the expression of RANKL/OPG. On the other hand, in addition to bone remodeling, the biology of tooth movement also focuses on other biological factors that influence the process of inflammatory response, cellular response and soft tissue response, these factors would play a crucial role in the adaptation of alveolar and periodontal tissues to the forces applied during orthopedic/orthodontic treatment of the cranio-cervical maxillofacial region.

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“…ERR is irreversible when the resorption involves the dentin. [10,11] Malocclusion is one of the most common dentoalveolar anomalies that impair oral function and craniofacial growth, typically associated with the impairment in breathing, chewing, speaking, and facial appearance. Therefore, the demand for orthodontic treatment is strong.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Osteoclastogenesis in Orthodontic Tooth Movement and Orthodontically Induced Tooth Root Resorption

Nakai,

Praneetpong,

Ono

et al. 2023

J Bone Metab

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Orthodontic tooth movement (OTM) is achieved by the simultaneous activation of bone resorption by osteoclasts and bone formation by osteoblasts. When orthodontic forces are applied, osteoclast-mediated bone resorption occurs in the alveolar bone on the compression side, creating space for tooth movement. Therefore, controlling osteoclastogenesis is the fundamental tenet of orthodontic treatment. Orthodontic forces are sensed by osteoblast lineage cells such as periodontal ligament (PDL) cells and osteocytes. Of several cytokines produced by these cells, the most important cytokine promoting osteoclastogenesis is the receptor activator of nuclear factor-κB ligand (RANKL), which is mainly supplied by osteoblasts. Additionally, osteocytes embedded within the bone matrix, T lymphocytes in inflammatory conditions, and PDL cells produce RANKL. Besides RANKL, inflammatory cytokines, such as interleukin-1, tumor necrosis factor-α, and prostaglandin E2 promote osteoclastogenesis under OTM. On the downside, excessive osteoclastogenesis activation triggers orthodontically-induced external root resorption (ERR) through pro-osteoclastic inflammatory cytokines. Therefore, understanding the mechanisms of osteoclastogenesis during OTM is essential in reducing the adverse effects of orthodontic treatment. Here, we review the current concepts of the mechanisms underlying osteoclastogenesis in OTM and orthodontically induced ERR.

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The Role of RANKL and Involvement of Cementum in Orthodontic Root Resorption

Cited by 5 publications

References 45 publications

RANK-RANKL-OPG: A current trends in orthodontic tooth movement and its role in accelerated orthodontics

RANK-RANKL-OPG: A current trends in orthodontic tooth movement and its role in accelerated orthodontics

Biology and Mechanobiology of the Tooth Movement during the Orthodontic Treatment

Mechanisms of Osteoclastogenesis in Orthodontic Tooth Movement and Orthodontically Induced Tooth Root Resorption

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