The Role of Reactive Species on Innate Immunity

Andrés, Celia María Curieses; Lastra, José Manuel Pérez de la; Juan, Celia Andrés; Plou, Francisco J.; Pérez‐Lebeña, Eduardo

doi:10.3390/vaccines10101735

Cited by 47 publications

(32 citation statements)

References 198 publications

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“…35 On the other hand, damage to the colon, increases due to increased levels of NO and, following that, reactive nitrogenous species, and reactive oxygen species. 36 It indicates the importance of NF-κB-INOS-NO signaling pathways in imposing oxidative stress and inflammation due to colitis. 34,37 So, the secretion of reactive products, including peroxides and superoxides, in inflamed mucosa, from active leukocytes, increases, and exacerbates oxidative damages to colon tissue.…”

Section: Discussionmentioning

confidence: 99%

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Quinic acid ameliorates ulcerative colitis in rats, through the inhibition of two TLR4‐NF‐κB and NF‐κB‐INOS‐NO signaling pathways

Ghasemi‐Dehnoo

Lorigooini

Amini‐Khoei

et al. 2023

Immunity Inflam & Disease

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ObjectiveIn this study, the therapeutic effect of quinic acid (QA), which has anti‐inflammatory activity, was investigated on acetic acid‐induced colitis in male Wistar rats.MethodsUlcerative colitis (UC) was induced in rats by acetic acid intrarectally, and the protective effects of QA in 10, 30, 60, and 100 mg/kg doses were investigated. Rats were treated for 5 days and their colon tissues were dissected out at the end. Macroscopic and histopathological examinations were performed in colon tissues. Also, the expression of inflammatory and apoptotic genes, including TLR4, IL‐1β, INOS, IL‐6, TNF‐α, NF‐κB, Caspase‐3, Caspase‐8, Bax, and Bcl‐2, was measured. Biochemistry indices, such as malondialdehyde (MDA) and nitrite oxide (NO) content, in addition to, total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), and enzymes activities were also assessed.ResultsColitis increased the levels of MDA and NO, and enhanced the inflammatory and apoptotic gene expressions, while reducing the SOD and CAT enzymes activity, and TAC levels in the colitis rats. Also, results showed that colitis was associated with the infiltration of inflammatory cells, epithelium damage, and edema in colon tissue. QA significantly ameliorated histopathological indices, oxidative stress, inflammation, and apoptosis in colitis rats.ConclusionQA ameliorated UC through the inhibition of two TLR4‐NF‐κB and NF‐κB‐INOS‐NO signaling pathways, which results in the reduction of colitis complications, including oxidative stress, inflammation, apoptosis and histopathological injuries in rats. Therefore it can be concluded, that QA exerts its therapeutic effects through antiapoptotic, antioxidant, and anti‐inflammatory properties.

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Section: Discussionmentioning

confidence: 99%

“…It has an important role in the production of inflammatory cytokines in relevant areas 35 . On the other hand, damage to the colon, increases due to increased levels of NO and, following that, reactive nitrogenous species, and reactive oxygen species 36 …”

Section: Discussionmentioning

confidence: 99%

Quinic acid ameliorates ulcerative colitis in rats, through the inhibition of two TLR4‐NF‐κB and NF‐κB‐INOS‐NO signaling pathways

Ghasemi‐Dehnoo

Lorigooini

Amini‐Khoei

et al. 2023

Immunity Inflam & Disease

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“…While innate immunity and acquired immunity were once thought to be unrelated, recent research has shown that the two are in fact closely intertwined [ 112 ]. All multicellular organisms have an innate immune system, a rudimentary defense mechanism that relies on macrophages, neutrophils, the complement system, natural killer cells, gamma delta T lymphocytes, and dendritic cells to function [ 113 ]. Figure 4 is an illustration of the immune system.…”

Section: Role Of Reactive Species On Innate and Adaptive Immunitymentioning

confidence: 99%

Myeloid-Derived Suppressor Cells in Cancer and COVID-19 as Associated with Oxidative Stress

et al. 2023

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Myeloid-derived suppressor cells MDSCs are a heterogeneous population of cells that expand beyond their physiological regulation during pathologies such as cancer, inflammation, bacterial, and viral infections. Their key feature is their remarkable ability to suppress T cell and natural killer NK cell responses. Certain risk factors for severe COVID-19 disease, such as obesity and diabetes, are associated with oxidative stress. The resulting inflammation and oxidative stress can negatively impact the host. Similarly, cancer cells exhibit a sustained increase in intrinsic ROS generation that maintains the oncogenic phenotype and drives tumor progression. By disrupting endoplasmic reticulum calcium channels, intracellular ROS accumulation can disrupt protein folding and ultimately lead to proteostasis failure. In cancer and COVID-19, MDSCs consist of the same two subtypes (PMN-MSDC and M-MDSC). While the main role of polymorphonuclear MDSCs is to dampen the response of T cells and NK killer cells, they also produce reactive oxygen species ROS and reactive nitrogen species RNS. We here review the origin of MDSCs, their expansion mechanisms, and their suppressive functions in the context of cancer and COVID-19 associated with the presence of superoxide anion •O2− and reactive oxygen species ROS.

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“…It is an antimicrobial agent in the human respiratory tract [ 42 ] that is harmless to cells and cytotoxic to bacteria and is being investigated for its ability as a complementary antibiotic. [ 43 ]…”

Section: Free Radicals and Rsmentioning

confidence: 99%

From reactive species to disease development: Effect of oxidants and antioxidants on the cellular biomarkers

Andrés

Lastra

Juan

et al. 2023

J Biochem & Molecular Tox

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The influence of modern lifestyle, diet, exposure to chemicals such as phytosanitary substances, together with sedentary lifestyles and lack of exercise play an important role in inducing reactive stress (RS) and disease. The imbalance in the production and scavenging of free radicals and the induction of RS (oxidative, nitrosative, and halogenative) plays an essential role in the etiology of various chronic pathologies, such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. The implication of free radicals and reactive species injury in metabolic disturbances and the onset of many diseases have been accumulating for several decades, and are now accepted as a major cause of many chronic diseases. Exposure to elevated levels of free radicals can cause molecular structural impact on proteins, lipids, and DNA, as well as functional alteration of enzyme homeostasis, leading to aberrations in gene expression. Endogenous depletion of antioxidant enzymes can be mitigated using exogenous antioxidants. The current interest in the use of exogenous antioxidants as adjunctive agents for the treatment of human diseases allows a better understanding of these diseases, facilitating the development of new therapeutic agents with antioxidant activity to improve the treatment of various diseases. Here we examine the role that RS play in the initiation of disease and in the reactivity of free radicals and RS in organic and inorganic cellular components.

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The Role of Reactive Species on Innate Immunity

Cited by 47 publications

References 198 publications

Quinic acid ameliorates ulcerative colitis in rats, through the inhibition of two TLR4‐NF‐κB and NF‐κB‐INOS‐NO signaling pathways

Quinic acid ameliorates ulcerative colitis in rats, through the inhibition of two TLR4‐NF‐κB and NF‐κB‐INOS‐NO signaling pathways

Myeloid-Derived Suppressor Cells in Cancer and COVID-19 as Associated with Oxidative Stress

From reactive species to disease development: Effect of oxidants and antioxidants on the cellular biomarkers

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