The Role of Reduced Glutathione on the Activity of Adenosine Deaminase, Antioxidative System, and Aluminum and Zinc Levels in Experimental Aluminum Toxicity

Atakisi, Onur; Dalginli, Kezban Yıldız; Gülmez, Canan; KALAÇAY, Destan; Atakişi, Emine; Zhumabaeva, T. T.; Aşkar, Tünay Kontaş; Demirdogen, Ruken Esra

doi:10.1007/s12011-022-03503-0

Cited by 2 publications

(1 citation statement)

References 62 publications

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“…It has been proven that various agents increase oxidative/nitrosative levels by showing toxic effects in the cell (Atakisi et al, 2022;Yildiz Dalginli et al, 2022;Gulmez et al, 2020;Kart et al, 2016). Cisplatin, an important cytotoxic agent, triggers oxidative stress and causes damage to the lungs and other tissues and organs (Leo et al, 2010).…”

Section: Immunohistochemical Findingsmentioning

confidence: 99%

Ratlarda Sisplatin Kaynaklı Akciğer Toksisitesi Üzerine Oksidatif/Nitrozatif Stres Parametrelerinin ve Histopatolojik, İmmünohistokimyasal Etkilerin Değerlendirilmesi

YILDIZ DALGINLI,

ÖZTÜRKLER,

BEŞEREN

et al. 2023

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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The main focus of this study is to investigate oxidative/nitrosative stress and antioxidant effects and immunohistochemical effects in cisplatin-induced lung toxicity. In the study, 12 male Sprague Dawley rats, 2 months old, were divided into two groups: control (n=6) and cisplatin (n=6). Isotonic solution was administered to control and cisplatin 10 mg/kg single dose intraperitoneal to cisplatin group. Reducte glutathione (GSH), malondialdehyde (MDA) and nitric oxide (NO) levels were determined by spectrophotometricmethod in the lung tissues taken. Paraffin blocks were made from lung tissues and stained with hematoxylin-eosin (HE) staining. Immunohistochemically, p53, CD3, CD20, Bcl-2 ve Ki67 were evaluated. It was found that cisplatin administration alone had no effect on MDA and GSH values in the lung tissue of rats, and NO levels were significantly increased (P

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