This article contains the methodology and main results related to the update and extension of the widest Interregional Input‐Output Tables for the entire EU27, UK and the EFTA countries. This work gives continuation to the outstanding effort developed in the last years regarding the estimation and analysis of different Multi‐Regional Input‐Output (MRIO) databases at the country level (WIOD, EXIOBASE, ICIO, FIGARO, etc), and the MRIO tables developed for the EU at the NUTS2 level. The main contribution consists of updating and extending the current EUREGIO collection to obtain an EUREGIO table for 2017, which will be referred to the regions (NUTS‐2 Rev.2016) for all the EU27+UK+EFTA countries and will be embedded in the new FIGARO multi‐country 2017. Such effort was developed in the context of the ESPON‐IRIE project. This article summarizes the methodology used and compares the results obtained with the ones of the main benchmarks, providing an analysis about the national and regional participation in the Global Value Chains (GVCs). Main results suggest that, on average, 65% of value added is embodied in the goods and services sold to the same NUTS‐2 region, 16% is embodied in the ones sold to regions in the same country, and the remaining 20% is exported (to other countries). Exploring the heterogeneity within these figures also can be seen that the variety is higher across regions than across sectors. Our analysis suggests that, to a large extent, the heterogeneous participation of EU27+UK+EFTA regions in the GVCs is explained by their sectoral structure, more than by the regional idiosyncratic characteristics. Such results open the floor for the correct design of industrial policies, embedded in the smart specialization paradigm.