The Role of Regulatory T Cells in Respiratory Infections and Allergy and Asthma

Abstract

The role of distinct CD4

Peripheral Blood and Tissue T Regulatory Cells in Chronic Rhinosinusitis

“…Our data do not distinguish between subtypes of Tregs (nTregs versus iTregs), and they do not incorporate newer markers for these cells, 11 something that will remain for future work. Similar studies investigating T-cell phenotypes in Chinese subjects with or without nasal polyps confirm a down-regulation of FoxP3 mRNA expression and significantly decreased numbers of FoxP3-positive Tregs in nasal polyp tissue.…”

“…Two distinct subsets of Tregs are recognized: natural Tregs (nTregs), which mature in the thymus and represent a small proportion of the peripheral CD4 ϩ T-cell population, and peripherally induced Tregs (iTregs), which are FoxP3 ϩ or FoxP3 Ϫ and generally secrete anti-inflammatory and immunosuppressive cytokines such as IL-10 and TGF-␤1. [9][10][11] Tregs have been shown to control effector immune responses through a diverse array of mechanisms. 3,9,10 These cells play roles in the coordination and regulation of recruitment of effector T cells to sites of inflammation and also have the ability to impair the capacity of antigen-presenting cells (APCs) to prime adaptive immune responses.…”

Increased frequencies of pulmonary regulatory T-cells in latentMycobacterium tuberculosisinfection

“…Treg cells seem to be involved in the regulation of M. tuberculosis-specific immune responses [2,15,26]. Their role in active TB has been described but their function during the early and latent stages of M. tuberculosis infection is unknown [18,[27][28][29][30][31].…”

“…Treg cells play an important role in modulating M. tuberculosisspecific immune responses [2,15]. In mice infected with M. tuberculosis, Treg cells start to expand once phagocytosed mycobacteria have been transported to mediastinal lymphnodes [16].…”

The Contrasting Roles of T Regulatory Cells in Bacterial Lung Diseases

“…T reg cells have long been implicated in the control of asthma, though the mechanisms through which they accomplish this control are still being studied (Lloyd & Hawrylowicz, 2009;McGuirk et al, 2010;Ray et al, 2010). Depletion of T reg cells in murine models of asthma has been shown to greatly exacerbate symptoms (Lewkowich et al, 2005).…”