This study presents a detailed feasibility analysis of technical and financial assessment for grid-connected Hybrid Renewable Energy System (HRES) configurations by including grid-only, HRES-only and grid-HRES at four different provinces in the Kingdom of Saudi Arabia (KSA), namely; (Al Baha University, University of Jeddah, Prince Sattam Bin Abdulaziz University, and Tabuk University). The objective of this paper is to search the possibility of supplying the load demand with the optimum system that has the lowest net present cost (NPC) and greenhouse emission CO2. The simulation results show that NPC of a proposed grid/PV system, at the current grid’s tariff, is more sufficient than other configurations with a result in a renewable fraction of more than 50%, a payback time of 17 years, and 54.3% reduction in CO2. The results also show that the integration of 62 kW PV array with the main grid is the best configuration that leads to the minimum cost of energy (COE) of 0.0688 $/kWh and the sell back energy of 9.16% of total energy consumption at Al Baha University. Besides, optimization modeling addresses that HRES-only system can supply the full load demand without power shortage (<0.1%) with a major contribution from solar PV by 78.5%, wind energy shares 11.3% of load demand, and 10.2% from battery banks. The developed analysis concludes that the objective function is feasible for the selected locations. The study has three novelties. Firstly, the required load at different locations of the university’s buildings at KSA is supplied by minimizing COE. The objective function is achieved by considering a combination of HRES. Then, it applies the sensitivity analysis for several cases such as payback time, gird’s tariff variation, and load demand change. Finally, the current analyses are applicable to any university at KSA and around the world.