The role of repair tension on tendon to bone healing in an animal model of chronic rotator cuff tears

Sclerostin Antibody Treatment Enhances Rotator Cuff Tendon-to-Bone Healing in an Animal Model

“…Rotator cuff tears are associated with loss of bone at the healing interface and a lack of regeneration of the functionally graded, mineralized fibrocartilage found in the healthy attachment 4 . Bone loss has been observed at healing tendon-to-bone interfaces at multiple anatomic sites [5][6][7][8][9][10][11] . The loss of mineralized tissue is likely caused by mechanical unloading during the period from tearing through surgical repair and by high osteoclast activity during the healing period after repair 10,12 .…”

The Role of Mechanical Loading in Tendon Development, Maintenance, Injury, and Repair

“…This complex, zonal interface is characterized by the integration of a tendon's collagen fibers transitioning through a fibrocartilaginous region into the mineralized bone. The differences in material properties of the soft and hard tissue lead to high stress concentrations at this site, contributing to injury [60][61][62][63][64] . In an effort to improve tendon-to-bone healing, the application of static or cyclic loading at the insertion site may be necessary to restore the zonal phenotype 60,[65][66][67] .…”

The Detrimental Effects of Systemic Ibuprofen Delivery on Tendon Healing Are Time-Dependent

“…Therefore, we evaluated the biomechanical and histologic effects of systemic NSAID administration on tendon healing when delivered immediately (for only the first week after surgery) or in a delayed fashion (for only the second week after surgery) when compared to no NSAID administration. Specifically, we used a commonly prescribed medication, ibuprofen, in our well-established rat rotator cuff model of supraspinatus tendon healing [12,14,29]. We hypothesized that early administration would inhibit rotator cuff healing, resulting in decreased mechanical properties and reduced tissue organization, while late administration would improve rotator cuff healing, resulting in increased mechanical properties and tissue organization.…”