The role of RNA metabolism in the pathogenesis of amyotrophic lateral sclerosis

Altered glucose catabolism in the presynaptic and perisynaptic compartments of SOD1G93A mouse spinal cord and motor cortex indicates that mitochondria are the site of bioenergetic imbalance in ALS

“…However, ALS is a very heterogeneous disorder, with many biological alterations that occur, often concomitantly, during disease progression, making it difficult to find a cure. These biological alterations include glutamate‐mediated excitotoxicity, oxidative stress, protein aggregation, mitochondrial dysfunction, impaired axonal transport, neuroinflammation, dysregulated RNA signaling, immunological imbalance, and environmental stress response (Callaghan et al ; Ferraiuolo et al ; King et al ; Peters et al ; Tan et al ; Lysogorskaia et al ; Van Den et al, ).…”