The role of rodlet cells in the inflammatory response in Phoxinus phoxinus brains infected with Diplostomum

Dezfuli, Bahram Sayyaf; Giari, Luisa; Shinn, Andrew P.

doi:10.1016/j.fsi.2006.11.003

Cited by 33 publications

(32 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Occurrence of RCs in reactive foci as a result of infection by micro-and macro-parasites has been reported [10,22,23]. Rodlet cells represent an inflammatory cell type closely linked to other piscine inflammatory cells, such as mast cell/EGCs [10,24], epithelioid and mesothelial cells [9].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Inflammatory response to Dentitruncus truttae (Acanthocephala) in the intestine of brown trout

Dezfuli

Giovinazzo

Lui

et al. 2008

Fish & Shellfish Immunology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

“…Rodlet cells represent an inflammatory cell type closely linked to other piscine inflammatory cells, such as mast cell/EGCs [10,24], epithelioid and mesothelial cells [9]. Rodlet cells have an important role in host defence [10,23,25].…”

Section: Discussionmentioning

confidence: 99%

Inflammatory response to Dentitruncus truttae (Acanthocephala) in the intestine of brown trout

Dezfuli

Giovinazzo

Lui

et al. 2008

Fish & Shellfish Immunology

View full text Add to dashboard Cite

“…Teleost fish possess rodlet cells, so named for the rod-shaped structures present within each cell, whose primary function appears to be to respond to tissue injury, especially in the cases of parasitic infection (Dezfuli et al, 2007;Matisz et al, 2010;Schmachtenberg, 2007). Brain-encysting metacercariae evoke a strong response by rodlet cells in freshwater minnows, where rodlet cells surround the offending worm and increase in density as more damage is incurred by developing metacercariae (Matisz et al, 2010).…”

Section: Immune Systemmentioning

confidence: 99%

“…Brain-encysting metacercariae evoke a strong response by rodlet cells in freshwater minnows, where rodlet cells surround the offending worm and increase in density as more damage is incurred by developing metacercariae (Matisz et al, 2010). Rodlet cells are not found in the brains of uninfected conspecifics (Dezfuli et al, 2007). Rodlet cells are thought to be a part of a larger inflammatory response that includes increased vascularization and a proliferation of fibroblasts to the site of injury (Matisz et al, 2010).…”

Section: Immune Systemmentioning

confidence: 99%

Comparing mechanisms of host manipulation across host and parasite taxa

Lafferty

Shaw

2013

Journal of Experimental Biology

169

167

View full text Add to dashboard Cite

SummaryParasites affect host behavior in several ways. They can alter activity, microhabitats or both. For trophically transmitted parasites (the focus of our study), decreased activity might impair the ability of hosts to respond to final-host predators, and increased activity and altered microhabitat choice might increase contact rates between hosts and final-host predators. In an analysis of trophically transmitted parasites, more parasite groups altered activity than altered microhabitat choice. Parasites that infected vertebrates were more likely to impair the hostʼs reaction to predators, whereas parasites that infected invertebrates were more likely to increase the hostʼs contact with predators. The site of infection might affect how parasites manipulate their hosts. For instance, parasites in the central nervous system seem particularly suited to manipulating host behavior. Manipulative parasites commonly occupy the body cavity, muscles and central nervous systems of their hosts. Acanthocephalans in the data set differed from other taxa in that they occurred exclusively in the body cavity of invertebrates. In addition, they were more likely to alter microhabitat choice than activity. Parasites in the body cavity (across parasite types) were more likely to be associated with increased host contact with predators. Parasites can manipulate the host through energetic drain, but most parasites use more sophisticated means. For instance, parasites target four physiological systems that shape behavior in both invertebrates and vertebrates: neural, endocrine, neuromodulatory and immunomodulatory. The interconnections between these systems make it difficult to isolate specific mechanisms of host behavioral manipulation.

show abstract

“…eosinophilic granulocyte) [31,32] is accepted, then an allocation of undifferentiated stages via blood vessels and immigration through endothelia and/or connective tissue may be assumed and would be comparable to the movement of true leucocytes observed inside and around the thymus. Indeed, a low number of mature RCs were found in blood vessels and connective tissue close to the thymus.…”

Section: Discussionmentioning

confidence: 99%