The role of rosemary extract (40% carnosic acid) in degeneration of hippocampal  neurons induced by kainic acid in the rat:The behavioral and histochemical approach

Naderali, Elahe; Nikbakht, Farnaz; Ofogh, Sattar Norouzi; Rasoolijazi, Homa

doi:10.31083/jin-170035

Cited by 9 publications

(5 citation statements)

References 51 publications

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“…In a similar study, GGRE improved memory functions in a mice model of LPS-induced neuroinflammation [ 41 ]. Moreover, RE has been shown to rescue learning and spatial memory deficits in a rat model of epilepsy induced by treatment with kainic acid [ 42 ]. Interestingly, a randomized clinical trial observed that RE treatment positively affected memory performance, anxiety, depression, and sleep quality in 34 Iranian university students [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

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Mediterranean natural extracts improved cognitive behavior in zebrafish and healthy rats and ameliorated lps-induced cognitive impairment in a sex dependent manner

et al. 2022

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Background Several findings suggest neuroinflammation as a contributing factor for the onset of psychiatric disorders such as Alzheimer’s disease, depression, and anxiety. There is increasing evidence pointing out that the Mediterranean diet influences brain and behavior. Mediterranean herbs and spices have been shown to be within those components of the Mediterranean diet involved in cognitive enhancement. Thus, we investigated the influence of Mediterranean natural extracts (MNE), Rosemary extract (RE) and Glycyrrhiza glabra root extract (GGRE), on cognitive behavior. Results Adult zebrafish were exposed to RE or GGRE (100 and 250 mg/L) treatments. Both MNE improved memory retention during the T-maze test, although no improvements were observed during the novel object preference. Similarly, chronic administration of RE (150 mg/Kg) and GGRE (150 mg/Kg) improved, respectively, spatial and retention memory, as assessed by the Morris Water Maze (MWM), and the Elevated Plus Maze (EPM) in healthy male rats. However, no improvements were observed during the novel object recognition. Finally, male, and female rats were chronically treated with lipopolysaccharide [(LPS) 300 ug/kg] and orally administered with RE. Interestingly, RE reversed LPS-induced cognitive deficit during the MWM and EPM in female rats. Conclusions We found that MNE improved cognition in both zebrafish and rats. Moreover, MNE rescued LPS-induced cognitive impairment in a gender-specific manner. Therefore, our study supports the view that zebrafish represent a valuable preclinical model for drug discovery in neuroscience. These findings contribute to an exciting and growing body of research suggesting that MNE may play an important role in the prevention of cognitive impairment.

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Section: Discussionmentioning

confidence: 99%

“…1 ). GGRE and RE treatments were based on previous studies where similar doses were applied [ 41 , 42 ].…”

Section: Methodsmentioning

confidence: 99%

Mediterranean natural extracts improved cognitive behavior in zebrafish and healthy rats and ameliorated lps-induced cognitive impairment in a sex dependent manner

et al. 2022

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“…The administration of RE and FLX in the present work resulted in a significant decrease in the escape latency and the number of errors indicating an improvement in cognition defects induced by MSG. These RE effects may be due to the induction of neurogenesis in the hippocampus through its antioxidant properties [ 13 , 27 ]. Chronic FLX administration had a significant recovery of the cognitive functions in rats with DG lesions [ 28 ].…”

Section: ⧉ Discussionmentioning

confidence: 99%

“…Rosmarinus officinalis (RO) is one of the popular herbs. Its extract has antioxidant properties attributed to its Carnosic Acid, phenolic diterpenes, and Carnosol content [ 13 ]. It has antiviral, anti-inflammatory, cytoprotective, antithrombotic, antidiabetic, and neuroprotective effects partly due to decreasing neuronal oxidative damage.…”

Section: ⧉ Introductionmentioning

confidence: 99%

Protective effects of Rosemary extract and/or Fluoxetine on Monosodium Glutamate-induced hippocampal neurotoxicity in rat

Atef

Fattah

Mahmoud³

et al. 2021

Rom J Morphol Embryol

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The use of Monosodium Glutamate (MSG) as a food flavor enhancer is increasing worldwide despite its neurotoxic effects. Fluoxetine (FLX) and Rosemary extract (RE) are known to have beneficial neuroprotective properties. Rats were divided into five groups: control group; MSG group, rats received 2 g/kg/day intraperitoneal (i.p.) injections of MSG for seven days; RE/MSG group, rats received 50 mg/kg/day of oral RE for 28 days starting prior to MSG; FLX/MSG group, rats received 10 mg/kg/day of oral FLX for 28 days beginning before MSG; and RE/FLX/MSG group, received combined treatments as mentioned above. Rats underwent the Barnes maze test, in addition to histopathological, immunohistochemical, morphometric and ultrastructural evaluations for their hippocampi. MSG increased the number of errors and escaped latency in the Barnes maze test that was significantly minimized in the three treatment groups. The MSG group exhibited pyramidal cell (PC) degeneration, shrunken glial cells and massive vascular dilatation that were improved with RE and/or FLX treatment. The number of glial fibrillary acidic protein (GFAP)-immunopositive cells were increased, and the number of PCs was decreased in the MSG group, while these values were significantly reversed with the three treatment groups with the most significant improvement at RE/FLX/MSG one. Ultrastructurally, PCs were shrunken with degenerated nuclei, dilated endoplasmic reticulum, swollen mitochondria, and vacuolations in the MSG group that were improved with RE and/or FLX. In conclusion, the combined RE and FLX treatment can ameliorate the toxic effect of MSG on rat hippocampus probably through its antioxidant and anti-inflammatory effects.

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“…Hematoxylin and eosin (H&E) staining. The pulmonary tissues were dissected from the mice in different groups as described (Naderali et al, 2018). Briefly, the pulmonary tissues were fixed by dipping in 4% paraformaldehyde for 48 hours, then the tissues were embedded in paraffin and cut into 3-4 μm thick slices.…”

Section: Methodsmentioning

confidence: 99%

Dexmedetomidine alleviates pulmonary ischemia-reperfusion injury through modulating the miR-21-5p/Nr4a1 signaling pathway

et al. 2020

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This study aims to investigate the protection of dexmedetomidine (Dex) against pulmonary ischemia-reperfusion injury (PIRI) in the mouse model and reveal the mechanism in hypoxia reoxygenation (H/R)-induced mouse pulmonary vascular endothelial cells (MPVECs). The lung wet-to-dry weight ratio, histopathological features, and malondialdehyde (MDA) concentrations were measured. The H/R-induced MPVECs were exposed to Dex, and the cell viability, cell apoptosis and protein expressions were assessed by the Cell Counting Kit-8 (CCK8) assay, flow cytometry and western blot, respectively. In addition, the regulatory relationship between miR-21-5p and orphan nuclear receptor 4A1 (Nr4a1) was revealed by several assays, including the dual-luciferase reporter assay, real-time quantitative polymerase chain reaction (RT-qPCR) and western blot. We found that the Dex treatment significantly alleviated pulmonary injury and decreased the level of MDA and wet/dry weight ratio in PIRI mice. Dex treatment also increased cell viability, reduced apoptotic ratio and downregulated expression levels of Cleaved Caspase-3 and Cleaved Caspase-9 in H/R induced MPVECs. Furthermore, the expression of miR-21-5p was upregulated, while Nr4a1 was downregulated by Dex in a concentration-dependent manner in H/R induced MPVECs. Moreover, Nr4a1 was verified as a target of miR-497-5p. Overexpression of Nr4a1 could reverse the protective effects of Dex on alleviating H/R-induced injury in MPVECs. Taken together, Dex treatment attenuated ischemia-reperfusion induced pulmonary injury through modulating the miR-21-5p/Nr4a1 signaling pathway.

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The role of rosemary extract (40% carnosic acid) in degeneration of hippocampal neurons induced by kainic acid in the rat:The behavioral and histochemical approach

Cited by 9 publications

References 51 publications

Mediterranean natural extracts improved cognitive behavior in zebrafish and healthy rats and ameliorated lps-induced cognitive impairment in a sex dependent manner

Mediterranean natural extracts improved cognitive behavior in zebrafish and healthy rats and ameliorated lps-induced cognitive impairment in a sex dependent manner

Protective effects of Rosemary extract and/or Fluoxetine on Monosodium Glutamate-induced hippocampal neurotoxicity in rat

Dexmedetomidine alleviates pulmonary ischemia-reperfusion injury through modulating the miR-21-5p/Nr4a1 signaling pathway

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