The role of rostral prefrontal cortex in prospective memory: A voxel-based lesion study

Volle, Emmanuelle; Gonen-Yaacovi, Gil; Costello, Angela; Gilbert, Sam J.; Burgess, Paul W.

doi:10.1016/j.neuropsychologia.2011.02.045

Cited by 127 publications

(99 citation statements)

References 88 publications

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“…This finding confirms previous decoding evidence that RLPFC encodes future intentions (Haynes et al, 2007;Soon et al, 2008;Momennejad and Haynes, 2012). Consistently, lesion studies demonstrate that damage to RLPFC impairs multitasking, PM, and hierarchical planned action (Burgess, 2000;Volle et al, 2011). Of the five decoding studies of delayed intentions, including the present study, one study did not find RLPFC encoding of delayed intentions .…”

Section: The Role Of the Rlpfcsupporting

confidence: 80%

“…It has been shown that univariate BOLD activation in RLPFC (lateral BA 10) plays an important role in event-based PM (Simons et al, 2006;Reynolds et al, 2009;Benoit et al, 2012), time-based PM (Okuda et al, 2007), and the comparison of time based and event-based PM Gilbert et al, 2005Gilbert et al, , 2006Gilbert et al, , 2009. Furthermore, lesions to these regions impair both time-based and event-based PM capacities (Burgess et al, 2000;McFarland and Glisky, 2009;Volle et al, 2011). However, univariate methods do not reveal whether these brain regions encode information regarding the content of delayed intentions across delays.…”

Section: Discussionmentioning

confidence: 99%

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Encoding of Prospective Tasks in the Human Prefrontal Cortex under Varying Task Loads

Momennejad

Haynes

2013

J. Neurosci.

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Successful realization of planned actions requires the brain to encode intentions over delays. Previous research has indicated that several regions in the rostral or anterior prefrontal cortex (PFC) encode delayed intentions. However, different processes may encode the same future task depending on task load during the delay. This difference may depend on the computational resources available when the delay is occupied with an ongoing task and when it is task-free. Here we directly investigated and compared the representation of delayed intentions in the human brain in the presence and absence of ongoing task load during the delay. We acquired fMRI data in combination with an event-based prospective memory design where human subjects remembered to perform the same future tasks over occupied and task-free delays. We used time-resolved multivoxel pattern classification and found that: (1) rostrolateral PFC (BA 46) encoded the delayed intention during both delay types; (2) rostromedial PFC (BA 10) encoded the intentions during occupied delays; whereas (3) a variety of more posterior regions, including the anterior cingulate cortex (BA 24), the supplementary motor area (BA 6), and the precuneus, encoded intentions during task-free delays. Overall, the medial PFC encoded delayed intentions more rostrally in the presence of an ongoing delay task and more caudally in its absence. Thus, rostromedial PFC may play a specialized role in the encoding of prospective memory that depends on higher computational demands (e.g., given higher task load during the delay). In contrast, the rostrolateral PFC is a more general area that encodes future intentions regardless of task load.

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Section: The Role Of the Rlpfcsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Encoding of Prospective Tasks in the Human Prefrontal Cortex under Varying Task Loads

Momennejad

Haynes

2013

J. Neurosci.

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“…The medial frontal cortical involvement BA 10) in the 'non-primed' group also agrees with other prospective memory paradigms (for an overview see Burgess et al, 2011). Especially the right and medial BA 10 region play a nonspecific role in memory when sustained attention or orientation of attention towards externally presented stimuli is required, for instance when response consistency has to be maintained (Burgess et al, 2007a, b;Volle et al, 2011). Furthermore, as medial BA 10 activation might reflect higher levels of anticipatory attention towards appearance of memory targets (Okuda et al, 2011), this might to some extent explain the faster RT observed in the 'non-primed' Group 2.…”

Section: Positive Versus Negative Emotional Primingsupporting

confidence: 79%

The influence of emotional priming on the neural substrates of memory: A prospective fMRI study using portrait art stimuli

Baeken

Raedt

Schuerbeek³

et al. 2012

NeuroImage

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Abstract AbstractEvents coupled with an emotional context seem to be better retained than non-emotional events. The aim of our study was to investigate whether an emotional context could influence the neural substrates of memory associations with novel portrait art stimuli. In the current prospective fMRI study, we have investigated for one specific visual art form (modern artistic portraits with a high degree of abstraction) whether memory is influenced by priming with emotional facial pictures. In total forty healthy female volunteers in the same age range were recruited for the study. Twenty of these women participated in a brain imaging memory paradigm and were asked to memorize a series of similar looking, but different portraits. After randomization, for twelve participants (Group 1), a third of the portraits was emotionally primed with approach-related pictures (smiling baby faces), a third with withdrawal-related pictures (baby faces with severe dermatological conditions), and another third with neutral images.Group 2 consisted of eight participants and they were not primed. Then, during an fMRI session two hours later, these portraits were viewed in random order intermixed with a set of new (previously unseen) ones, and the participants had to decide for each portrait whether or not they had already been seen. In a separate experiment, a different sample of twenty healthy females (Group 3) rated their mood after being exposed to the same art stimuli, without priming. The portraits did not evoke significant mood changes by themselves, supporting their initial neutral emotional character (Group 3).The correct decision on whether the portraits were Familiar of Unfamiliar led to similar neuronal activations in brain areas implicated in visual and attention processing for both groups (Group 1 and 2). In contrast, whereas primed participants showed significant higher neuronal activities in the left midline superior frontal cortex (Brodmann area (BA) 6), unprimed volunteers displayed higher right medial frontal cortical (BA 10) activities. Furthermore, specifically in Group 1, correct retrieval of negatively primed portraits evoked increased neuronal activity in the left medial orbitofrontal cortex (BA 11) and in the right (posterior) insula, suggesting enhanced stress-related responses to the memory of withdrawal-related primed modern artistic portraits in this group. Our prospective memory data in healthy females indicate that, to reach a correct retrieval decision, different midline anterior 3 neuronal networks are recruited for portraits that were emotionally primed than for the unprimed ones. Importantly, our results also suggest that the negative emotional context leads to the formation of associations that are reactivated during memory retrieval processes of the initially neutral art portraits.When correctly recognized, the portraits evoke neuronal activities consistent with the withdrawalrelated character of the emotional visual stimuli with which they have been associated. Although o...

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“…Indeed as noted above patients with right polar prefrontal BA10 lesions were shown to be impaired in time based PM (Volle et al 2011). It is also possible that the DLPFC more generally (including BA6 BA9) may similarly be implicated.…”

Section: Discussionmentioning

confidence: 70%

Prospective memory deficits in illicit polydrug users are associated with the average long-term typical dose of ecstasy typically consumed in a single session.

Gallagher¹,

Hadjiefthyvoulou²,

Fisk³

et al. 2014

Neuropsychology

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Prospective memory deficits in illicit polydrug users are associated with the average long term typical dose of ecstasy typically consumed in a single session. AbstractRationale Neuroimaging evidence suggests that ecstasy-related reductions in SERT densities relate more closely to the number of tablets typically consumed per session rather than estimated total lifetime use. In order to better understand the basis of drug related deficits in prospective memory (PM) we explored the association between PM and average long-term typical dose and long-term frequency of use. Method Study 1: Sixty five ecstasy/polydrug users and 85 non-ecstasy users completed an event based, a short-term and a long-term time based PM task. Study 2: Study 1 data were merged with outcomes on the same PM measures from a previous study creating a combined sample of 103 ecstasy/polydrug users, 38 cannabis-only users and 65 nonusers of illicit drugs. Results Study 1: Ecstasy/polydrug users had significant impairments on all PM outcomes compared to non-ecstasy users. Study 2:Ecstasy/polydrug users were impaired in event based PM compared to both other groups and in long-term time based PM compared to non illicit drug users. Both drug using groups did worse on the short-term time based PM task compared to nonusers. Higher long-term average typical dose of ecstasy was associated with poorer performance on the event and short-term time based PM tasks and accounted for unique variance in the two PM measures over and above the variance associated with cannabis and cocaine use. Conclusions The typical ecstasy dose consumed in a single session is an important predictor of PM impairments with higher doses reflecting increasing tolerance giving rise to greater PM impairment.

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The role of rostral prefrontal cortex in prospective memory: A voxel-based lesion study

Cited by 127 publications

References 88 publications

Encoding of Prospective Tasks in the Human Prefrontal Cortex under Varying Task Loads

Encoding of Prospective Tasks in the Human Prefrontal Cortex under Varying Task Loads

The influence of emotional priming on the neural substrates of memory: A prospective fMRI study using portrait art stimuli

Prospective memory deficits in illicit polydrug users are associated with the average long-term typical dose of ecstasy typically consumed in a single session.

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