In the present investigation, dissimilar materials such as electrolytic tough pitch copper and aluminum 6061-T651 were welded by friction stir welding technology. Effects of tool tilt angle on mechanical and metallurgical properties were studied experimentally for dissimilar materials system. In the present study, the tool tilt angle was varied from 0˚ to 4˚ with an interval of 1˚ while the other parameters such as rotational speed, welding speed, tool pin offset, workpiece material position were kept constant. Macrostructure analysis, tensile test, macro hardness measurement, scanning electron microscopy and energy dispersive x-ray spectrographic tests were performed to evaluate weld properties of dissimilar copper-aluminum joint. The results revealed that a defect free dissimilar copper-aluminum friction stir welding was achieved by tilt angles 2˚, 3˚ and 4˚.Maximum tensile strength was reported 117 MPa and macro hardness was reported 181 VH (in nugget zone) at the 4˚ tilt angle. Macro hardness was increased as tilt angle increases from 0˚ to 4˚. In addition to this, thermo-mechanically affected zone (at copper side) was found to be the weakest zone for dissimilar copper-aluminum friction stir welding system.