The role of salivary function in modulating chemotherapy-induced oropharyngeal mucositis: A review of the literature

Epstein, Joel B.; Tsang, Andrew H.F.; Warkentin, Dawn; Ship, Jonathan A.

doi:10.1067/moe.2002.126018

Cited by 92 publications

(88 citation statements)

References 28 publications

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“…Some patients even after therapies have less of a sense of taste [10]. Other important issues are increased nausea and vomiting symptoms, loss of appetite and CRT effects decreasing the patient's weight and fitness condition [11].…”

Section: Quality Of Lifementioning

confidence: 99%

Head and Neck Cancer Patients’ Quality of Life

et al. 2014

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Patients suffering from head and neck cancers often require a multidisciplinary approach before and after surgery. Restoration of facial esthetics, speech, mastication and others often requires a long-lasting, divided rehabilitation. Quality of life (QOL) is measurable in a patient's life before and after surgery and complete treatment. The state of QOL has different parameters depending on the patient's clinical diagnosis, type of treatment and surgeries performed. In this paper, the authors are focusing on the quality of life of patients suffering from head and neck cancers and a proper multidisciplinary approach to achieving proper functions will be described. Also, the patient's self-esteem improvement and psychological evaluation is necessary (Adv Clin Exp Med 2014, 23, 6, 1019-1027).

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Section: Quality Of Lifementioning

confidence: 99%

Head and Neck Cancer Patients’ Quality of Life

et al. 2014

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“…The CMF (cyclophosphamide, methotrexate and 5-fluorouracil) and CEF protocol agents (cyclophosphamide, epirubicin and 5-fluorouracil), and their derivatives, can be detected in saliva for days after the infusion (18). Dysgeusia is an important symptoms in these patients, since apart from the direct neurotoxic effect upon the gustatory cells, it is reinforced by other factors such as xerostomia, infections, and the psychological conditions of the patient (21).…”

Section: Oral Infectionsmentioning

confidence: 99%

Dental treatment considerations in the chemotherapy patient

López¹,

Esteve²,

Pérez³

2011

J Clin Exp Dent

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Cancer patients can suffer oral toxic effects secondary to antineoplastic therapy in the form of radiotherapy and/ or chemotherapy. This risk is conditioned by a range of factors, including the high cell turnover rate of the oral mucosa, the diversity and complexity of the oral microflora, and soft tissue trauma during normal oral function. The present study offers a literature review of the main oral complications secondary to chemotherapy, and describes the different options for dental treatment before, during and after oncological treatment, published in the scientific literature. To this effect a PubMed-Medline® search was made using the following keywords: chemotherapy, cancer therapy, dental management, oral mucositis, neurotoxicity, intravenous bisphosphonates and jaw osteonecrosis. The search was limited to human studies published in the last 10 years in English or Spanish. A total of 50 articles were identified: 17 research papers, 25 reviews, 6 letters to the Editor, and two clinical guides developed by expert committees. The data obtained showed the main oral complications of chemotherapy to be mucositis, neurotoxicity, susceptibility to infections, dental, salivary and taste alterations, and the development of osteonecrosis. Based on the reviewed literature, elective dental treatment can be provided before chemotherapy, with emphasis on the elimination of infectious foci. During chemotherapy, dental treatment should be limited to emergency procedures, while dental treatment of any kind can be prescribed after chemotherapy -with special considerations in the case of patients who have received treatment with intravenous bisphosphonates.

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“…Vários autores investigaram a presença de quimioterápicos, administrados por via endovenosa, na saliva, sugerindo possível toxicidade local (BARRET, 1987;EPSTEIN et al, 2002;MILANO et al, 1989;SLAVIK;WU;RILEY, 1993). Outros relacionaram efeitos sobre a composição e fluxo salivares associados à quimioterapia como possível causa de interferência na expressão da mucosite oral (EPSTEIN et al, 2002;JANKOVIC et al, 1995;McCARTHY et al, 1998).…”

Section: Discussionunclassified

“…Outros relacionaram efeitos sobre a composição e fluxo salivares associados à quimioterapia como possível causa de interferência na expressão da mucosite oral (EPSTEIN et al, 2002;JANKOVIC et al, 1995;McCARTHY et al, 1998). Embora esses fatos possam contribuir com a instalação e severidade dos quadros de mucosite associada à quimioterapia, certamente os mecanismos envolvidos estão decisivamente ligados à imunidade e processos de reparo tecidual individuais, desde que os resultados, em uma população com mesma doença de base e protocolo terapêutico, exibiram indivíduos sem expressão de mucosite em seis ciclos;…”

Section: Discussionunclassified

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Laser de baixa potência na prevenção de mucosite em pacientes submetidos à quimioterapia com fluorouracil e ácido folínico

Gambirazi¹

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The role of salivary function in modulating chemotherapy-induced oropharyngeal mucositis: A review of the literature

Cited by 92 publications

References 28 publications

Head and Neck Cancer Patients’ Quality of Life

Head and Neck Cancer Patients’ Quality of Life

Dental treatment considerations in the chemotherapy patient

Laser de baixa potência na prevenção de mucosite em pacientes submetidos à quimioterapia com fluorouracil e ácido folínico

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