The Role of Saponins in the Treatment of Neuropathic Pain

Tan, Bei; Wu, Xueqing; Yu, Jie; Chen, Zhong

doi:10.3390/molecules27123956

Cited by 9 publications

(3 citation statements)

References 132 publications

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“…Tannins may influence the inflammatory reaction by inhibiting iNOS in macrophages and scavenging free radicals ( Wang et al, 2019 ). On the other side, saponins lessen discomfort and inflammation by suppressing nitric oxide release ( Suresh et al, 2021 ; Tan et al, 2022 ). Therefore, saponins, alkaloids, flavonoids, tannins, terpenoids, and phenols may be responsible for CL’s effects on pain relief and inflammation.…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive and antiinflammatory activities of crude leave extract and solvent fractions of Commelina latifolia Hochst. ex C.B.Clarke (Commelinaceae) leaves in murine model

Tadege,

Sirak,

Abebe

et al. 2023

Front. Pharmacol.

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Ethnopharmacological relevance: In the past, Ethiopian traditional medicine employed the leaves of the native Commelina latifolia Hochst. ex C.B. Clarke plant to treat wounds, pain, and malaria.Aim of the study: The crude extract and solvent fractions of C. latifolia Hochst. ex C.B. Clarke leaves were examined in the present investigation to determine their ability to have an antiinflammatory effect and provide an antinociceptive effect in animal models.Materials and methods: The leaves of C. latifolia were extracted with 80% methanol, and the CL crude extract was further fractionated with chloroform, pure methanol, and distilled water. The carrageenan-induced paw edema model was used to test the extracts’ ability to reduce inflammation. The hotplate model and the acetic acid-induced writhing test on rodents were used to test the extracts’ potential antinociceptive effect to reduce pain.Results: Inflammation was decreased by 64.59% with CL crude extract (400 mg/kg); 56.34% (400 mg/kg) of methanol fraction, 64.59% of aqueous fraction (400 mg/kg), and 38.27% of chloroform fraction in the carrageenan-induced inflammatory model. All extracts demonstrated a considerable lengthening of the nociception reaction time in the hot plate test, with a maximum antinociceptive effect of 78.98% (crude extract) and 71.65% (solvent fractions). At a dosage of 400 mg/kg, the natural C. latifolia crude extract and aqueous fraction demonstrated considerable antinociceptive effects against acetylsalicylic acid (ASA) during the writhing test (48.83% and 45.37than%, respectively). The current findings support Ethiopia’s traditional user’s assertions that the herb can alleviate inflammation and pain.

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Section: Discussionmentioning

confidence: 99%

Antinociceptive and antiinflammatory activities of crude leave extract and solvent fractions of Commelina latifolia Hochst. ex C.B.Clarke (Commelinaceae) leaves in murine model

Tadege,

Sirak,

Abebe

et al. 2023

Front. Pharmacol.

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“…Undoubtedly, a comprehensive examination of the limitations associated with harnessing saponins for their anti‐inflammatory properties is imperative for a nuanced and informative review. The intricacies of these considerations are outlined below, serving as a structured guide to facilitate a thorough exploration (Hassan et al, 2012; Tan et al, 2022). In addressing limitations, a critical consideration revolves around the constrained bioavailability of specific saponins, potentially impeding their absorption and distribution within the body.…”

Section: Limitations Associated With Harnessing Saponins For Their An...mentioning

confidence: 99%

Critical review on anti‐inflammation effects of saponins and their molecular mechanisms

Wijesekara,

Luo,

2024

Phytotherapy Research

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This review highlights the increasing interest in one of the natural compounds called saponins, for their potential therapeutic applications in addressing inflammation which is a key factor in various chronic diseases. It delves into the molecular mechanisms responsible for the anti‐inflammatory effects of these amphiphilic compounds, prevalent in plant‐based foods and marine organisms. Their structures vary with soap‐like properties influencing historical uses in traditional medicine and sparking renewed scientific interest. Recent research focuses on their potential in chronic inflammatory diseases, unveiling molecular actions such as NF‐κB and MAPK pathway regulation and COX/LOX enzyme inhibition. Saponin‐containing sources like Panax ginseng and soybeans suggest novel anti‐inflammatory therapies. The review explores their emerging role in shaping the gut microbiome, influencing composition and activity, and contributing to anti‐inflammatory effects. Specific examples, such as Panax notoginseng and Gynostemma pentaphyllum, illustrate the intricate relationship between saponins, the gut microbiome, and their collective impact on immune regulation and metabolic health. Despite promising findings, the review emphasizes the need for further research to comprehend the mechanisms behind anti‐inflammatory effects and their interactions with the gut microbiome, underscoring the crucial role of a balanced gut microbiome for optimal health and positioning saponins as potential dietary interventions for managing chronic inflammatory conditions.

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“…The sugar chain in saponins has a strong hydrophilicity due to the varying degrees of lipophilicity of the aglycone, and the aqueous solution can form persistent, soap-like foam after shaking (Li & Monje-Galvan, 2023). Several studies have demonstrated that saponins, which are isolated from a variety of Chinese herbal remedies, may have analgesic effects in a variety of NP models, which has significant promise for the creation of new analgesic pharmaceuticals (Tan et al, 2022). The typical are aescin and ginsenoside Rh2.…”

Section: Saponinsmentioning

confidence: 99%

Treatment of neuropathic pain by traditional Chinese medicine: An updated review on their effect and putative mechanisms of action

Guo,

Zhang,

Feng

2024

Phytotherapy Research

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Neuropathic pain (NP) is a common chronic pain with heterogeneous clinical features, and consequent lowering of quality of life. Currently, although conventional chemical drugs can effectively manage NP symptoms in the short term, their long‐term efficacy is limited, and they come with significant side effects. In this regard, traditional Chinese medicine (TCM) provides a promising avenue for treating NP. Numerous pharmacological and clinical studies have substantiated the effectiveness of TCM with multiple targets and mechanisms. We aimed to outline the characteristics of TCM, including compound prescriptions, single Chinese herbs, active ingredients, and TCM physical therapy, for NP treatment and discussed their efficacy by analyzing the pathogenesis of NP. Various databases, such as PubMed, Web of Science, China National Knowledge Infrastructure, and Wanfang database, were searched. We focused on recent research progress in NP treatment by TCM. Finally, we proposed the future challenges and emerging trends in the treatment of NP. TCM demonstrates significant clinical efficacy in NP treatment, employing multi‐mechanisms. Drawing from the theory of syndrome differentiation, four types of dialectical treatments for NP by compound TCM prescriptions were introduced: promoting blood circulation and removing blood stasis; promoting blood circulation and promote Qi flow; warming Yang and benefiting Qi; soothing the liver and regulating Qi. Meanwhile, 33 single Chinese herbs and 25 active ingredients were included. In addition, TCM physical therapy (e.g., acupuncture, massage, acupoint injection, and fumigation) also showed good efficacy in NP treatment. TCM, particularly through the use of compound prescriptions and acupuncture, holds bright prospects in treating NP owing to its diverse holistic effects. Nonetheless, the multi‐targets of TCM may result in possible disadvantages to NP treatment, and the pharmacological mechanisms of TCM need further evaluation. Here, we provide an overview of NP treatment via TCM, based on the pathogenesis and the potential therapeutic mechanisms, thus providing a reference for further studies.

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The Role of Saponins in the Treatment of Neuropathic Pain

Cited by 9 publications

References 132 publications

Antinociceptive and antiinflammatory activities of crude leave extract and solvent fractions of Commelina latifolia Hochst. ex C.B.Clarke (Commelinaceae) leaves in murine model

Antinociceptive and antiinflammatory activities of crude leave extract and solvent fractions of Commelina latifolia Hochst. ex C.B.Clarke (Commelinaceae) leaves in murine model

Critical review on anti‐inflammation effects of saponins and their molecular mechanisms

Treatment of neuropathic pain by traditional Chinese medicine: An updated review on their effect and putative mechanisms of action

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