The role of MiRNA‐433 in malignant tumors of digestive tract as tumor suppressor

Abstract

Background MicroRNAs (miRNAs) are a class of short non‐coding RNAs with a length of approximate 22 nuclei acids that can be expressed both as an oncogene and tumor suppressor gene in human cancers. MiRNAs can participate in the post‐ transcriptional regulation of gene expression, and regulate the several cancer‐related processes, including proliferation, apoptosis, metastasis, etc. Recent findings Expression of miRNA‐433 has been reported to vary in different tumors and affected by various factors. We have summarized the different previous studies and found that miRNA‐433 can significantly inhibit the growth of the cancer cells not only in malignant tumors of the digestive tract, but also in lung cancer, breast cancer, cervical cancer, ovarian cancer, bladder cancer, renal carcinoma, glioma, retinoblastoma and osteosarcoma. Conclusion When the expression of miRNA‐433 was up‐regulated, the proliferation, metastasis and invasion abilities of the malignant tumor cells were significantly inhibited. At the same time, the potential mechanisms through which miRNA‐433 can suppress the growth and metastasis of the cancer cells were found to be basically the same, and involved modulation of the specific signaling pathways or target genes in the malignant tumors. Overall, it can be concluded that miRNA‐433 can serve as potential and valuable therapeutic target.

Chemokine Ligand 2 Promotes Migration in Osteosarcoma by Regulating the miR-3659/MMP-3 Axis

“…MMP3 is regulated by various miRNAs [18,19], subsequently facilitating tumor cell invasion and metastasis [15][16][17]. The abnormal expression of miRNAs has been closely associated with processes such as tumor cell invasion and metastasis in osteosarcoma [18,19,[52][53][54]. For example, the increased expression of MMP-3 induces tumor metastasis in osteosarcoma by inhibiting miR-519d [19], and miR-134 reduces osteosarcoma cell invasion and metastasis by targeting MMP-3 in vivo and in vitro [18].…”

Biomarker potential of competing endogenous RNA networks in Polycystic Ovary Syndrome (PCOS)

“…Studies have shown that overexpression of miR-433-5p prevents motor impairment and inflammation by targeting MAPK1 [ 180 ]. Moreover, miR-433-5p has been reported to suppress cancer cell proliferation and metastasis by modulating tumor signaling pathways or target genes [ 181 ]. Lower levels of hepatic PIK3CD in type 2 diabetes have been associated with decreased insulin sensitivity induced by miR-125b [ 182 ].…”

Therapeutic Delivery of Tumor Suppressor miRNAs for Breast Cancer Treatment

“…As per the research done in 2020 by Jinhui Xue et al, the existence speed of the high-expression group was much higher than that of the low-expression group. This result raised the possibility that miRNA-433 could be a marker for the malignancy of mammary cancer [ 36 ]. Shiqin Liu et al initially argued that miRNA-433 could decrease tumor growth in ER+ BC by preventing M2 macrophage polarisation.…”