The role of <scp>NF</scp><i>κ</i>B in the three stages of pregnancy – implantation, maintenance, and labour: a review article

Sakowicz, Agata

doi:10.1111/1471-0528.15172

Cited by 49 publications

(46 citation statements)

References 90 publications

(217 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While the first and third trimesters are considered to be pro-inflammatory, the second trimester is anti-inflammatory [42]. Prior to conception, NFκB expression is high in the decidua where it assists in regulating the implantation window [43]. The first trimester of pregnancy is considered to be pro-inflammatory due to the dominance of the pro-inflammatory cytokine profile identified from blood of pregnant women [42].…”

Section: Nfκb Throughout Normal Pregnancymentioning

confidence: 99%

“…The third trimester of pregnancy is driven by a pro-inflammatory state [42]. NFκB is highly expressed in the decidua, where it assists in preparing for parturition by inducing cervical ripening and degradation of the extra-cellular matrix to initiate the rupture of placental membranes [43]. Moreover, NFκB is known to directly regulate factors that are present during labor, such as IL-8, cyclooxygenase-2 (COX2), and prostaglandins [43].…”

Section: Nfκb Throughout Normal Pregnancymentioning

confidence: 99%

See 1 more Smart Citation

The Role of NFκB in Healthy and Preeclamptic Placenta: Trophoblasts in the Spotlight

Armistead

Kadam

Drewlo

et al. 2020

IJMS

View full text Add to dashboard Cite

The NFκB protein family regulates numerous pathways within the cell—including inflammation, hypoxia, angiogenesis and oxidative stress—all of which are implicated in placental development. The placenta is a critical organ that develops during pregnancy that primarily functions to supply and transport the nutrients required for fetal growth and development. Abnormal placental development can be observed in numerous disorders during pregnancy, including fetal growth restriction, miscarriage, and preeclampsia (PE). NFκB is highly expressed in the placentas of women with PE, however its contributions to the syndrome are not fully understood. In this review we discuss the molecular actions and related pathways of NFκB in the placenta and highlight areas of research that need attention

show abstract

Section: Nfκb Throughout Normal Pregnancymentioning

confidence: 99%

Section: Nfκb Throughout Normal Pregnancymentioning

confidence: 99%

The Role of NFκB in Healthy and Preeclamptic Placenta: Trophoblasts in the Spotlight

Armistead

Kadam

Drewlo

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…Nuclear factor kappa B is a transcriptional factor and one of the most important regulators of immune and inflammatory processes . During the menstrual cycle, NF‐κB coordinates the mRNA expression of IL‐6 or IL‐8, which are involved in endometrial tissue remodeling . During early pregnancy in mice, NF‐κB mediates implantation and pregnancy maintenance .…”

Section: Discussionmentioning

confidence: 99%

Peroxisome proliferator‐activated receptor alpha regulates the expression of the immune response mediators in the porcine endometrium during the estrous cycle and early pregnancy

Kunicka

Kurzyńska

Szydłowska

et al. 2019

American J Rep Immunol

View full text Add to dashboard Cite

Problem Cytokines are immune response mediators that play an important role in the regulation of reproductive functions. An association between cytokines and peroxisome proliferator receptors (PPARs) has been reported in various tissues, including the endometrium. The present study aimed to evaluate the impact of PPARα ligands on the expression of nuclear factor kappa B (NF‐κB) and cytokines (interleukin [IL]‐1β, IL‐4, IL‐6, IL‐8, IL‐10, and LIF) in the porcine endometrium in different reproductive stages. Methods of study Endometrial slices were collected from gilts on days 10‐12 or 14‐16 of the estrous cycle and pregnancy. Endometrial tissue explants were incubated in vitro in the presence or absence of PPARα agonist WY‐14643 and antagonist MK886. Expression of mRNA and protein for NF‐ĸB and selected cytokines was evaluated by real‐time PCR and immunoblot. Results PPARα agonist WY‐14643 decreased the mRNA expression of NF‐κB in most of the analyzed stages (excluding days 10‐12 of the estrous cycle), but increased the expression of NF‐κB protein (excluding days 14‐16 of pregnancy). The WY‐14643 increased expression of IL‐1β and IL‐6 proteins, and the mRNA expression of IL‐8 and LIF, decreased IL‐4 expression, and did not affect the mRNA and protein expression of IL‐10. Conclusion The obtained results demonstrate that PPARα is involved in the regulation of NF‐κB and cytokine expression in the porcine endometrium. PPARα ligands exert a varied influence on immune system components, which could be attributed to differences in the receptivity of porcine endometrial tissue during the reproductive cycle.

show abstract

“…6a). In human endometrium, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) levels are typically elevated during the premenstrual phase and during early pregnancy and these increases may regulate molecules vital for implantation [30,31]. The NF-κB is sequestered in the cytoplasm as an inactive complex bound with an inhibitor of NF-κB (IκB) and is activated by separation and degradation of IκB [32][33][34].…”

Section: Bcb Induced Cox-2 Inos and Iκbα Expressions In Ru486treatementioning

confidence: 99%

Administration of Herb Formulation Enhanced Blastocyst Implantation via Iκb Activation in Mouse Endometrium

Jeon

Liu

Cai

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundBaelan Chagsang Bang (BCB), consisting of a mixture of 11 herbs, may be prescribed as a reproductive function supplement to improve ovulation and implantation during the treatment of infertility and recurrent abortion in Oriental Medicine. This study aimed to investigate the effects and mechanisms of action of water-extracted BCB on endometrial receptivity and blastocyst implantation in a mifepristone (RU486)-induced implantation failure model.MethodsIn in vitro, antioxidant potentials of BCB were evaluated using DPPH and superoxide anion radical scavenging assays and DCFH-DA assay. In vivo, C57BL/6 female mice (n = 6 per group) orally received BCB (300 mg/kg/day), a dose similar to that used clinically. BCB was administrated from 7 days before pregnancy until the end of the experiment. They were housed with male mice until pregnancy was confirmed. On day 4 of pregnancy, RU486 (4 mg/kg) was injected subcutaneously to induce implantation failure.ResultsAdministration of the BCB water extract increased the number of newborn pups in BCB-treated mice compared to that of sham-treated mice and improved the number of implantation sites in pregnant mice despite RU486 injection. BCB increased the protein expression level of cyclooxygenase-2 and inducible nitric oxide synthase through IκB activation. Moreover, the expression level of matrix metalloproteinases (MMPs) at the uterus implantation site was up-regulated in the BCB-treated group compared to that of the RU486-treated group. To determine the mechanisms of action of BCB, the anti-oxidative effect of BCB was examined via in vitro assay. The BCB water extract showed strong anti-oxidative effects in the DPPH assay and the superoxide anion free-radical scavenging activity assay.ConclusionOur findings provide evidence that BCB has therapeutic potential against poor endometrial receptivity.

show abstract

The role of NFκB in the three stages of pregnancy – implantation, maintenance, and labour: a review article

Abstract: This review examines the current state of knowledge about role of NFκB in the development of pregnancy.

Cited by 49 publications

References 90 publications

The Role of NFκB in Healthy and Preeclamptic Placenta: Trophoblasts in the Spotlight

The Role of NFκB in Healthy and Preeclamptic Placenta: Trophoblasts in the Spotlight

Peroxisome proliferator‐activated receptor alpha regulates the expression of the immune response mediators in the porcine endometrium during the estrous cycle and early pregnancy

Administration of Herb Formulation Enhanced Blastocyst Implantation via Iκb Activation in Mouse Endometrium

Contact Info

Product

Resources

About