The role of <scp>NMDA</scp> receptor‐dependent activity of noradrenergic neurons in attention, impulsivity and exploratory behaviors

Cieślak, Przemysław Eligiusz; Llamosas, Nerea; Kos, Tomasz; Ugedo, Luisa; Jastrzębska, Kamila; Torrecilla, Rosa Cañada; Parkitna, Jan Rodriguez

doi:10.1111/gbb.12383

Cited by 16 publications

(13 citation statements)

References 43 publications

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“…We previously found that NA release in the auditory midbrain of S. bombifrons differed in response to conspecific (S. bombifrons) and heterospecific (S. multiplicata) mating calls (Burmeister et al, 2017), suggesting that a role for NA in auditory processing of social signals may be conserved. Interestingly, levels of NA in the preoptic area of S. bombifrons, in contrast, were modified by diet in a manner that mirrored adult social preferences (Burmeister et al, 2017), an effect that is broadly consistent with a role for NA in behavioural flexibility and motivation (Jahn et al, 2018;Lapiz and Morilak, 2006;Cie slak et al, 2017).…”

Section: Introductionmentioning

confidence: 55%

Differential encoding of signals and preferences by noradrenaline in the anuran brain

Burmeister

Moncalvo

Pfennig

2020

Journal of Experimental Biology

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Social preferences enable animals to selectively interact with some individuals over others. One influential idea for the evolution of social preferences is that preferred signals evolve because they elicit greater neural responses from sensory systems. However, in juvenile plains spadefoot toad (Spea bombifrons), a species with condition-dependent mating preferences, responses of the preoptic area, but not of the auditory midbrain, mirror adult social preferences. To examine whether this separation of signal representation from signal valuation generalizes to other anurans, we compared the relative contributions of noradrenergic signalling in the preoptic area and auditory midbrain of S. bombifrons and its close relative Spea multiplicata. We manipulated body condition in juvenile toads by controlling diet and used high pressure liquid chromatography to compare call-induced levels of noradrenaline and its metabolite MHPG in the auditory midbrain and preoptic area of the two species. We found that calls from the two species induced different levels of noradrenaline and MHPG in the auditory system, with higher levels measured in both species for the more energetic S. bombifrons call. In contrast, noradrenaline levels in the preoptic area mirrored patterns of social preferences in both S. bombifrons and S. multiplicata. That is, noradrenaline levels were higher in response to the preferred calls within each species and were modified by diet in S. bombifrons (with condition-dependent preferences) but not S. multiplicata (with condition-independent preferences). Our results are consistent with a potentially important role for preoptic noradrenaline in the development of social preferences and indicate that it could be a target of selection in the evolution of condition-dependent social preferences.

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Section: Introductionmentioning

confidence: 55%

Differential encoding of signals and preferences by noradrenaline in the anuran brain

Burmeister

Moncalvo

Pfennig

2020

Journal of Experimental Biology

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“…One study tested how NMDA receptor dependent activity of NA neurons in performance of sustained attention and showed the loss of NMDA receptors associated with decreased sustained attention cognitively and increased impulsivity at the level of behavior. 37 Sustained attention deficits are frequently reported in psychiatric and physical conditions. Esterman et al 38 reported that failure of inhibition on the sustained attention test was higher in patients with PTSD and substance use disorder.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Performance of Attention Task and Suicidal Ideation in Korean Patients with Mood Disorders

Kim

Kong

2020

Psychiatry Investig

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Objective We examined the performance of attention tests related to suicidal ideation in mood disorder patients and to explain the difference of attention test performance in relation to suicidal ideation after controlling clinical and psychological variables of mood disorder patients.Methods Seventy-three in- and outpatients with major depressive disorder (n=41) or bipolar disorder (n=32) completed a self-rating questionnaire assessing socio-demographic characteristics, and clinical and psychological variables. Comprehensive Attention Test (CAT) also was conducted.Results Thirty-three patients were the high-suicidal ideation (SI) group, and forty patients were the low-SI group. The errors of commission (CEs) of visual sustained attention in the high-SI group was 6.3 times higher on average than that of the low-SI group. After controlling for sex, age, and diagnosis, a higher number of CEs on visual sustained attention tasks predicted higher SI score. However, after controlling for sex, age, diagnosis, and depressive mood, this predictive ability was no longer observed.Conclusion This study showed that CE on the visual sustained attention task seems to influence suicidal ideation as a result of interaction with depressive symptoms.

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“…The Go/no-go test was performed based on protocols previously used by us (Cieslak et al , 2017). Details of the procedure can be found in the Supplemental Methods.…”

Section: Methodsmentioning

confidence: 99%

Several behavioral traits relevant for alcoholism are controlled by ɣ2 subunit containing GABAA receptors on dopamine neurons in mice

Stojakovic

Walczak

Cieślak

et al. 2018

Neuropsychopharmacol

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The risk factors for developing alcohol addiction include impulsivity, high sensitivity to the rewarding action of ethanol and low sensitivity to its sedative and intoxicating effects. Genetic variation in GABAA receptor subunits, including the ɣ2 subunit (Gabrg2), affects the risk for developing alcoholism. Alcohol directly potentiates GABAA receptors and activates the mesolimbic dopamine system. Here, we deleted Gabrg2 selectively in dopamine cells of adult mice. The deletion resulted in elevated firing of dopamine neurons and made them less sensitive to drugs acting at GABAA receptors. At the behavioral level, the deletion increased exploratory behavior and augmented both correct and incorrect responding in the go/no-go task, a test often used to assay the response inhibition component of impulsivity. In addition, conditioned place preference to alcohol, but not to cocaine or morphine, was increased. Ethanol-induced locomotor activation was enhanced in the mice lacking Gabrg2 on dopaminergic cells whereas the sedative effect of alcohol was reduced. Finally, the alcohol drinking, but not the alcohol preference, at a high concentration was increased in the mutant mice. In summary, deletion of Gabrg2 on dopamine cells induced several behavioral traits associated with high risk of developing alcoholism. The findings suggest that mice lacking Gabrg2 on dopaminergic cells could be used as models for individuals at high risk for developing alcoholism and that GABAA receptors on dopamine cells are protective against the development of excessive alcohol drinking.

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The role of NMDA receptor‐dependent activity of noradrenergic neurons in attention, impulsivity and exploratory behaviors

Cited by 16 publications

References 43 publications

Differential encoding of signals and preferences by noradrenaline in the anuran brain

Differential encoding of signals and preferences by noradrenaline in the anuran brain

The Relationship between Performance of Attention Task and Suicidal Ideation in Korean Patients with Mood Disorders

Several behavioral traits relevant for alcoholism are controlled by ɣ2 subunit containing GABAA receptors on dopamine neurons in mice

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