The role of selenium in iodine metabolism in children with goiter.

Zagrodzki, Paweł; Szmigiel, Hanna; Ratajczak, Ryszard; Szybiński, Z; Zachwieja, Z.

doi:10.1289/ehp.0010867

Cited by 27 publications

(4 citation statements)

References 22 publications

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“…In formula-fed preterm infants a gender-related effect on Se metabolism was reported by Friel et al (1993). In Poland, a gender-linked hormonal response to concomitant Se and I deficiency in older children (7 -16 years) with goitre was reported by Zagrodzki et al (2000). In breast-fed infants, Yoshinaga et al (1991) showed a significant association between milk Se and gender, but Cumming et al (1992b ) reported no significant difference in breast-milk Se due to the infant's gender.…”

Section: Selenium Interactions and Breast-feedingmentioning

confidence: 97%

Selenium and breast-feeding

Dórea

2002

Br J Nutr

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The objective of the present review is to discuss Se nutrition during breast-feeding, encompassing environmental and maternal constitutional factors affecting breast-milk-Se metabolism and secretion. A literature search of Medline and Webofscience was used to retrieve and select papers dealing with Se and breast milk. Although Se in natural foods occurs only in organic form, breast milk responds to organic and inorganic Se in supplements. Inorganic Se (selenite, selenate), which is largely used in maternal supplements, is not detectable in breast milk. The mammary-gland regulating mechanism controls the synthesis and secretion of seleno-compounds throughout lactation, with a high total Se level in colostrum that decreases as lactation progresses. Se appears in breast milk as a component of specific seleno-proteins and selenoamino-acids in milk proteins that are well tolerated by breast-fed infants even in high amounts. Se in breast milk occurs as glutathione peroxidase (4 -32 % total Se) . selenocystamine . selenocystine . selenomethionine. The wide range of breast-milk Se concentrations depends on Se consumed in natural foods, which reflects the Se content of the soils where they are grown. Se prophylaxis, either through soil Se fertilization or maternal supplements, is effective in raising breast-milk Se concentration. In spite of wide variation, the median Se concentration from studies worldwide are 26, 18, 15, and 17 mg/l in colostrum (0 -5 d), transitional milk (6 -21 d), mature milk (1 -3 months) and late lactation (.5 months) respectively. Se recommendations for infants are presently not achieved in 30 % of the reported breast-milk Se concentrations; nevertheless Se status is greater in breast-fed than in formula-fed infants.

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Section: Selenium Interactions and Breast-feedingmentioning

confidence: 97%

Selenium and breast-feeding

Dórea

2002

Br J Nutr

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“…The beneficial effects of iodine on morphological parameters of animal blood are evidenced by the works of Lima et al, 1989;Moreno-Reyes et al, 2003;Zagrodzki et al, 2000. Conclusion Feed iodine supplements had a positive effect on hematopoietic organs: their usage helped to improve the overall condition of the blood: the number of red blood cells has increased by 1.4-6.7%, hemoglobin-by 5.3-8.8% and leukocytes-by 4.4-7.6%.…”

Section: Resultsmentioning

confidence: 90%

The effect of different forms of iodine on the blood parameters of sheep

Gogaev¹,

Demurova²,

Ikoeva³

et al. 2020

Journal of Livestock Science

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Iodine is an extremely important substance for living beings, which has a versatile biological activity and provides functional activity of almost all body systems due to participation in metabolism. The use of inorganic compounds of iodine salts is not always effective enough, as they are unstable, easily oxidized in air, as a result, the content of available iodine significantly reduces. In this regard, a promising direction in the correction of iodine deficiency is the use of organic forms of iodine, when the element is in chemical connection with any organic substance. Nowadays the work in this direction is conducted in Limited liability company "Phili N-Pharm" (Moscow) they let out the iodine-containing additives "Yoddar" and "Yoddar-Zn". The scientific and economic experience to study the impact of different forms of iodine feedings on the productivity of lactating sheep of Tushin breed was conducted in the Joint stock company "Saniba" the suburban district of the Republic of North Ossetia-Alania in the period from 2016 to 2017. For the experiment, 40 purebred young ewes, originating from first-class ewes and one inseminator sheep, were selected at birth. All the lambs were divided into 4 groups with 10 lambs in each: one control group and three experimental groups. The maintenance and feeding conditions of all groups were similar; the only difference was that the experienced young ewes' groups received different iodine medicaments in addition to their diet. The amount of iodine fertilizing was added to the feed based on the calculation of 2 mg of iodine per 1 kg of dry matter of the diet. Feed iodine supplements had a positive effect on the hematopoietic organs: their use helped to improve the overall condition of the blood: the number of red blood cells increased by 1.4-6.7%, hemoglobin-by 5.3-8.8% and leukocytes-by 4.4-7.6%. The best results on these indicators were obtained in lambs of experimental groups receiving "Yoddar-Zn".

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“…In our study, no association was found between selenium and iodine, and thyroid hormones (Table 5). However, several studies indicated that effects of selenium deficiency or excess on thyroid hormone biosynthesis in severe ID were more likely to be more pronounced than in mild ID [40][41][42][43]. Although, according to Rasmussen et al (2011), optimal selenium status might help to prevent iodine deficiency disorders (IDD), particularly thyroid gland enlargement.…”

Section: Methodsmentioning

confidence: 99%

Iodine status in European women in New Zealand with moderate selenium deficiency

Jowitt¹,

Duxbury²

2017

Integr Mol Med

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For the optimal function of thyroid gland, adequate intakes of iodine and selenium are required. Since iodine is essential component of the thyroid hormones, its insufficiency leads to inadequate hormone production and further to inadequate tissue response (hypothyroidism), goitre, stillbirth and miscarriages, and growth retardation. According to the World Health Organisation the recommended median urinary iodine concentrations (UIC) are the best indicators of iodine nutrition. The WHO defines iodine sufficiency in an adult population as a median UIC of > 100 µg/L in spot urine samples. Iodine deficiency was and still is a problem in New Zealand. In September 2009 the mandatory fortification of all bread with iodized salt was introduced. Therefore, the primary aim of the study was to determine the levels of iodine in both groups, and the secondary aim of the study was to determine whether there is a relationship between selenium and iodine, and iodine and thyroid hormones in two groups of European women. Urinary iodine concentration was determined in spot samples by the new method called "Fast B", which is improved Sandell-Kolthoff reaction. The results of the study showed the mean urinary iodine level in the control group and the group of women with the Hashimoto's thyroiditis was 120.77± 59.35 (median UIC was128.00 µg/L), and 98.64 ± 62.83 (median UIC was 95.00 µg/L), respectively. Estimated daily iodine intake of 150µg/ day was achieved in five participants in the control group, and four participants in the group of women with Hashimoto's thyroiditis. Estimated median iodine intake in the control group and Hashimoto's group was 142.22 and 105.55, respectively, indicating mild iodine deficiency. There was no significant relationships found between iodine and selenium, and iodine and thyroid hormones in both groups. The results of the current study are in line with the results from larger studies carried out in New Zealand. Iodine intakes appear to have improved after the mandatory fortification of bread with iodised salt in 2009, although iodine deficiency is still a problem in New Zealand. Using an iodine fortified bread clearly made an impact on the overall iodine intake but not to the expected level. There was no association found between iodine and selenium, and iodine and thyroid hormones. Any possible interaction between selenium and iodine is still unclear.

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The role of selenium in iodine metabolism in children with goiter.

Cited by 27 publications

References 22 publications

Selenium and breast-feeding

Selenium and breast-feeding

The effect of different forms of iodine on the blood parameters of sheep

Iodine status in European women in New Zealand with moderate selenium deficiency

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