The Role of Semipurified Fractions Isolated from <i>Quercus infectoria</i> on Bone Metabolism by Using hFOB 1.19 Human Fetal Osteoblast Cell Model

Abdullah, Anas; Hapidin, Hermizi; Abdullah, Huda

doi:10.1155/2018/5319528

Cited by 11 publications

(11 citation statements)

References 51 publications

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“…Pyrogallol is known to be associated with many biological activities and implicated in many anti-microbial activities such as anti-bacterial, anti-candidicidal and anti-fungicidal (43). Interestingly, Abdullah et al (44) recently revealed that different semi purifed fractions of the aqueous extract of Q. infectoria have similar polyphenolic compositions such as gallic acid and digallate as well as ellagic acid, syringic acid and theogallin, which have also been detected using liquid chromatography mass spectrometry (LC-MS), implying the richness of phenolic compounds in the galls. Similarly, ethanol extract of Q. infectoria galls has also been shown for their high content of phenolic compounds such as p-Hydroxybenzoic, pyrogallol, catechol, caffeine and gallic acid (31).…”

Section: Resultsmentioning

confidence: 99%

A Review of Quercus infectoria (Olivier) Galls as a Resource for Anti-parasitic Agents: In Vitro and In Vivo Studies

Zin

Rahimi

Bakar

2019

MJMS

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Parasitic diseases represent one of the causes for significant global economic, environmental and public health impacts. The efficacy of currently available anti-parasitic drugs has been threatened by the emergence of single drug- or multidrug-resistant parasite populations, vector threats and high cost of drug development. Therefore, the discovery of more potent anti-parasitic drugs coming from medicinal plants such as Quercus infectoria is seen as a major approach to tackle the problem. A systematic review was conducted to assess the efficacy of Q. infectoria in treating parasitic diseases both in vitro and in vivo due to the lack of such reviews on the anti-parasitic activities of this plant. This review consisted of intensive searches from three databases including PubMed, Science Direct and Scopus. Articles were selected throughout the years, limited to English language and fully documented. A total of 454 potential articles were identified, but only four articles were accepted to be evaluated based on inclusion and exclusion criteria. Although there were insufficient pieces of evidence to account for the efficacy of Q. infectoria against the parasites, this plant appears to have anti-leishmanial, anti-blastocystis and anti-amoebic activities. More studies in vitro and in vivo are warranted to further validate the anti-parasitic efficacy of Q. infectoria.

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Section: Resultsmentioning

confidence: 99%

A Review of Quercus infectoria (Olivier) Galls as a Resource for Anti-parasitic Agents: In Vitro and In Vivo Studies

Zin

Rahimi

Bakar

2019

MJMS

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“…The presence of phenolic compounds in QIG has been extensively quantified, with 50%-70% polyphenols as principal compounds [39] . This kind of water-soluble components is obviously the most in the aqueous extract, but in this anti CRC activity test, the ethanol extract of QIG shows the strongest effect.…”

Section: Discussionmentioning

confidence: 99%

Study on Compounds Analysis and Anti Colorectal Cancer Efficacy of Quercus Infectoria Galls’ Different Polar Solvent Extracts

Elham

Arkin

Kalimanjan

et al. 2021

Preprint

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Background Quercus Infectoria galls (QIG) has multiple therapeutic properties and are widely used in Traditional Medicine (TM) as an anti-inflammatory agent for inflammatory bowel disease (IBD). QIG aqueous extract has been verified to inhibit the proliferation of Colorectal cancer (CRC) cells but there is no relevant research on the contribution of material basis of QIG towards the efficacy at present. This research aims to clarify the pharmacodynamic discrepancy of different polar solvent extracts of QIG and the underlying link between material basis and anti CRC efficacy. Methods Four different QIG extracts and residues was prepared by using a modified method and the effective compounds polyphenols, tannins and gallic acid (GA) was determined by analytical methods including Thin Layer Chromatography, Ultraviolet-visible spectrophotometry, High Performance Liquid Chromatography and Infrared spectroscopy. Then GA and four different QIG extracts’ anti CRC activity against human HCT-116 and Caco-2 cells were tested in vitro by CCK-8 assay, wound-healing assay and apoptosis assay, at the end entropy weight method was used to comprehensively assess the anti CRC activities for discern the most active one among the four different QIG extracts. Results The content determination experiment shows that the content of active compounds in the four extracts increased with the increase of the polarity of the extraction solvent. The content of polyphenols, tannins and GA in aqueous extracts ranks first, reaching 562.66 ± 8.45 mg·mL− 1, 463.85 ± 4.62mg·mL− 1, 169.86 ± 3.24mg·mL− 1, respectively, followed by methanol, ethanol, and acetone, and the content order of them in residues is opposite to that in extracts. The in vitro pharmacodynamic experiments showed that all four extracts and GA could inhibit the proliferation and migration, induce apoptosis of CRC cells in different degrees. The entropy score of ethanol extract ranks first (0.5546 and 0.5436), followed by methanol (0.2264 and 0.1989), acetone (0.1961 and 0.1011) and aqueous (0.0596 and 0.1454). After the intervention of ethanol extract, the proliferation inhibition rate of ethanol extract on HCT-116 and Caco-2 cells reached 76.55% and 78.8%, migration inhibition rate reached 76.48% and 64.85%, and the induced apoptosis rate increased by 20.1% and 12.6%, respectively. Therefore, it is verified that QIG ethanol extract possess the strongest inhibitory effect on CRC cells. In addition, GA also showed strong anti-cancer activity as the main compound of QIG. Conclusions These findings will lead to further studies on the bioactivity-guided isolation of compounds from the ethanol extracts of QIG, and provide a basis for the research of mechanism.

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“…The presence of phenolic compounds in Q. infectoria galls have been extensively quantified, with 50%–70% tannic acid, gallic acid and ellagic acid as principal constituents ( 7 , 40 ). Among these phenolic compounds, ellagic acid has been widely studied exhibiting promising antimalarial activities against P. falciparum in vitro ( 41 ), P. vinckei in vivo ( 41 ), P. yeolli in vivo ( 42 ) and P. berghei in vivo ( 43 ) without any toxicity ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

In Vitro Antimalarial and Toxicological Activities of Quercus infectoria (Olivier) Gall Extracts

Zin

Mohamad

Roslan

et al. 2020

MJMS

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Background The spread of Plasmodium falciparum resistance in common antimalarial drugs, including artemisinin-based combination therapies, has necessitated the discovery of new drugs with novel mechanisms of action. In the present study, the in vitro antimalarial and toxicological activities of acetone, methanol, ethanol and aqueous extracts of Quercus infectoria ( Q. infectoria ) galls were investigated. Methods The extracts were assessed for the antimalarial potential using a malarial SYBR Green I fluorescence-based (MSF) assay, while the toxicity was screened by using brine shrimp lethality test (BSLT), haemolytic assay, and cytotoxicity assay against normal embryo fibroblast cell line (NIH/3T3) and normal kidney epithelial cell line (Vero). Results The acetone extract showed the highest antimalarial activity (50% inhibitory concentration, IC 50 = 5.85 ± 1.64 μg/mL), followed by the methanol extract (IC 50 = 10.31 ± 1.90 μg/mL). Meanwhile, the ethanol and aqueous extracts displayed low antimalarial activity with IC 50 values of 20.00 ± 1.57 and 30.95 μg/mL ± 1.27 μg/mL, respectively. The significant antimalarial activity was demonstrated in all extracts and artemisinin ( P < 0.05). All extracts were non-toxic to brine shrimps (50% lethality concentration, LC 50 > 1000 ppm). Furthermore, no occurrence of haemolysis (< 5%) was observed in normal erythrocytes when treated with all extracts compared to Triton X-100 that caused 100% haemolysis ( P < 0.05). The acetone and methanol extracts were non-toxic to the normal cell lines and statistically significant to artemisinin ( P < 0.05). Conclusion Taken together with satisfactory selectivity index (SI) values, the acetone and methanol extracts of Q. infectoria galls could serve as an alternative, promising and safe antimalarial agents.

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The Role of Semipurified Fractions Isolated from Quercus infectoria on Bone Metabolism by Using hFOB 1.19 Human Fetal Osteoblast Cell Model

Cited by 11 publications

References 51 publications

A Review of Quercus infectoria (Olivier) Galls as a Resource for Anti-parasitic Agents: In Vitro and In Vivo Studies

A Review of Quercus infectoria (Olivier) Galls as a Resource for Anti-parasitic Agents: In Vitro and In Vivo Studies

Study on Compounds Analysis and Anti Colorectal Cancer Efficacy of Quercus Infectoria Galls’ Different Polar Solvent Extracts

In Vitro Antimalarial and Toxicological Activities of Quercus infectoria (Olivier) Gall Extracts

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