The Role of Senescence in NASH-Related HCC

Chrysavgis, Lampros; Papadopoulos, Grigorios; Chatzigeorgiou, Antonios

doi:10.1007/16833_2022_87

Cited by 1 publication

(1 citation statement)

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“…Indeed, the authors observed an increased expression of p16, CDK4, and β-galactosidase, inversely related to cyclin D1, p53, and p21 involvement, indicating that senescence is activated via the p16 pathway during hepatocarcinogenesis induced by DEN [118]. In NASH-related HCC, the accumulation of senescent cells was shown to favor the occurrence of the disease [119]. Moreover, higher expression levels of four cellular senescence-related genes, EZH2, G6PD, CBX8, and NDRG, have been associated with the increased migration and invasion of HCC, as well as with a worse prognosis in patients [120].…”

Section: Senescence In Hepatocellular Carcinoma (Hcc)mentioning

confidence: 97%

Cellular Senescence in Liver Cancer: How Dying Cells Become “Zombie” Enemies

Gazzillo,

Volponi,

Soldani

et al. 2023

Biomedicines

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Liver cancer represents the fourth leading cause of cancer-associated death worldwide. The heterogeneity of its tumor microenvironment (TME) is a major contributing factor of metastasis, relapse, and drug resistance. Regrettably, late diagnosis makes most liver cancer patients ineligible for surgery, and the frequent failure of non-surgical therapeutic options orientates clinical research to the investigation of new drugs. In this context, cellular senescence has been recently shown to play a pivotal role in the progression of chronic inflammatory liver diseases, ultimately leading to cancer. Moreover, the stem-like state triggered by senescence has been associated with the emergence of drug-resistant, aggressive tumor clones. In recent years, an increasing number of studies have emerged to investigate senescence-associated hepatocarcinogenesis and its derived therapies, leading to promising results. In this review, we intend to provide an overview of the recent evidence that unveils the role of cellular senescence in the most frequent forms of primary and metastatic liver cancer, focusing on the involvement of this mechanism in therapy resistance.

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Section: Senescence In Hepatocellular Carcinoma (Hcc)mentioning

confidence: 97%