The Role of Senescent CD8+T Cells in the Pathogenesis of Disseminated Leishmaniasis
Cayo A. Abreu,
Maurício Teixeira Nascimento,
Olívia Bacellar
et al.
Abstract:Disseminated leishmaniasis (DL) caused by L. braziliensis is characterized by the presence of 10 to more than 1000 lesions spread on the body. While protection against Leishmania is mediated by macrophages upon activation by IFN-γ produced by CD4+T cells, the pathology of disseminated leishmaniasis (DL) could be mediated by macrophages, NK, and CD8+T cells. Herein, we evaluate the participation of senescent CD8+T cells in the pathogenesis of DL. Methods: Peripheral blood mononuclear cells (PBMCs), biopsies, co… Show more
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