The role of sensory input of the chorda tympani nerve and the number of fungiform papillae in burning mouth syndrome

Nasri-Heir, Cibele; Gomes, Julyana; Heir, Gary M.; Ananthan, Sowmya; Benoliel, Rafael; Teich, Sorin; Eliav, Eli

doi:10.1016/j.tripleo.2011.02.035

Cited by 65 publications

(61 citation statements)

References 37 publications

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“…The main affected sites are the tongue, palate, and/or the gingiva [4][5][6] . It is considered idiopathic, and current evidence has classified it as neuropathic.…”

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confidence: 99%

“…It is considered idiopathic, and current evidence has classified it as neuropathic. One of the most widely accepted theories is that there is disinhibition of the trigeminal nerve due to partial or total loss of chorda tympani ( facial) nerve function 6 . However, recent findings also showed that trigeminal neuropathy may be directly involved, and that gustatory abnormalities can be secondary 3 .…”

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confidence: 99%

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The role of xerostomia in burning mouth syndrome: a case-control study

Silva

Siqueira

Teixeira

et al. 2014

Arq. Neuro-Psiquiatr.

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Objective: To assess the efficacy of anti-xerostomic topical medication (urea 10%) in patients with burning mouth syndrome (BMS). Method: Thirty-eight subjects diagnosed with BMS according to the International Association for the Study of Pain guidelines were randomized to either placebo (5% sodium carboxymethylcellulose, 0.15% methyl paraben, and 10% glycerol in distilled water qsp 100 g) or treatment (urea 10%) to be applied to the oral cavity 3-4 times per day for 3 months. The patients were evaluated before and after treatment with the following instruments: the EDOF-HC protocol (Orofacial Pain Clinic -Hospital das Clínicas), a xerostomia questionnaire, and quantitative sensory testing. Results: There were no differences in salivary flow or gustative, olfactory, or sensory thresholds (P>0.05). Fifteen (60%) patients reported improvement with the treatments (P=0.336). Conclusion: In conclusion, there were no differences between groups, and both exhibited an association between reported improvement and salivation.Keywords: xerostomia, salivary flow, orofacial pain, quantitative sensory testing, burning mouth syndrome. RESUMOObjetivo: Avaliar a eficácia do uso de medicação tópica anti xerostomica (ureia 10%) em pacientes com síndrome de ardência bucal. Método: Trinta e oito sujeitos diagnosticados com síndrome de ardência bucal de acordo com os critérios da Associação Internacional para Estudo da Dor foram randomizados para grupo placebo (5% de carboximetilcelulose de sódio, 0,15% de metilparabeno e 10% de glicerol em água destilada qsp 100g) ou grupo tratamento (ureia 10%) para ser aplicada na cavidade oral 3-4 vezes ao dia, durante três meses. Os pacientes foram avaliados antes e depois do tratamento: protocolo EDOF-HC, questionário de xerostomia, testes sensitivos quantitativos. Resultados: Não houve diferenças no fluxo salivar, limiares gustativos, olfativos e somestésicos (Mann-Whitney P>0,05). Quinze (60%) dos pacientes tiveram melhora com o tratamento (P=0,336, oneway ANOVA). Conclusão: Em conclusão não houve diferenças entre os grupos, ambos apresentaram uma associação entre melhora e salivação.Palavras-chave: xerostomia, fluxo salivar, dor orofacial, teste sensitivo quantitativo, síndrome ardência bucal.

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“…The main affected sites are the tongue, palate, and/or the gingiva [4][5][6] . It is considered idiopathic, and current evidence has classified it as neuropathic.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

The role of xerostomia in burning mouth syndrome: a case-control study

Silva

Siqueira

Teixeira

et al. 2014

Arq. Neuro-Psiquiatr.

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“…A number of researchers have posited trigeminal small-fiber neuropathy as a cause of BMS (18,19). Because older individuals often complain of dysgeusia followed by BMS, dysfunction of the chorda tympani nerve may represent a cause of BMS (20,21). In the present study, the central nervous system disorders were associated with psychosocial disturbances and may strongly contribute to BMS in middle-aged patients.…”

Section: Discussionmentioning

confidence: 54%

Characteristics of middle-aged and older patients with temporomandibular disorders and burning mouth syndrome

et al. 2015

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“…The electrogustatory test revealed that response varied significantly among patients with BMS symptoms for over 41 months, though the number of fungiform taste buds did not vary 36 . However, another study found a comparatively high density of fungiform taste buds in BMS patients 37 .…”

Section: Gustatory Changesmentioning

confidence: 94%

Burning Mouth Syndrome –Latest update

Tomattis¹,

Munerato²

2016

Int J Dentistry Res

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Introduction: Burning mouth syndrome (BMS) is characterized by a recurrent daily burning sensation with no evidence lesions in the oral mucosa. It is accompanied by subjective dry mouth and dysgeusia. The tongue is the most commonly affected site, but the condition also affects other sites in the mouth. Its etiopathogeny is multifactorial and its diagnosis is made by exclusion. Objective: This article reviews the literature about the epidemiology, etiopathogeny, and diagnosis of BMS in the past 15 years. Articles were selected from PubMed/MEDLINE, and included clinical assays, case reports, and reviews. We found 509 articles, and only 136 were chosen. The key words were: burning mouth syndrome (BMS), review, etiopathogeny, diagnosis. Conclusions: BMS remains an important diagnostic challenge, though the disease is considered a neuropathy characterized by damage to trigeminal peripheral nervous fibers, which triggers central sensitization. In addition to BMS and secondary BMS, it seems relevant to include complicated BMS, in which symptoms persist despite the elimination of local and systemic causes. BMS should be investigated by a transdisciplinary team that will take into account all aspects active in the mental and physical dimensions of the condition, in the most detailed way. Therefore, QST, imaging investigations, various evaluation scales of mental health and of the impact of BMS on quality of life as well as the investigation of sleep disorders and changes in circadian rhythm could be useful tools in the development of treatment strategies based on findings and observing the characteristics of each BMS patient in light of specifics of diagnosis.

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The role of sensory input of the chorda tympani nerve and the number of fungiform papillae in burning mouth syndrome

Cited by 65 publications

References 37 publications

The role of xerostomia in burning mouth syndrome: a case-control study

The role of xerostomia in burning mouth syndrome: a case-control study

Characteristics of middle-aged and older patients with temporomandibular disorders and burning mouth syndrome

Burning Mouth Syndrome –Latest update

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