The role of serotonin in adolescent suicide: theoretical, methodological, and clinical concerns

Picouto, María Dolores; Villar-Cabeza, Francisco; Braquehais, María Dolores

doi:10.1515/ijamh-2015-5003

Cited by 13 publications

(10 citation statements)

References 32 publications

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“…The dysregulation of serotonergic has been widely studied in adults and has been postulated as a biological marker for suicide. [29][30][31][32] Serotonin regulates growth and maturation of some cerebral regions (e.g. hippocampal neurogenesis) in the developing brain, [33][34][35] and it influences secretion of TSH and thyrotropin-releasing hormone (TRH).…”

Section: Risk Factors Of Si Among Mddmentioning

confidence: 99%

<p>Identifying Suicidal Ideation Among Chinese Patients with Major Depressive Disorder: Evidence from a Real-World Hospital-Based Study in China</p>

Ge¹,

Jiang²,

Wang³

et al. 2020

NDT

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These authors contributed equally to this work Background: A growing body of research suggests that major depressive disorder (MDD) is one of the most common psychiatric conditions associated with suicide ideation (SI). However, how a combination of easily accessible variables built a utility clinically model to estimate the probability of an individual patient with SI via machine learning is limited. Methods: We used the electronic medical record database from a hospital located in western China. A total of 1916 Chinese patients with MDD were included. Easily accessible data (demographic, clinical, and biological variables) were collected at admission (on the first day of admission) and were used to distinguish SI with MDD from non-SI using a machine learning algorithm (neural network). Results: The neural network algorithm distinguished 1356 out of 1916 patients translating into 70.08% accuracy (70.68% sensitivity and 67.09% specificity) and an area under the curve (AUC) of 0.76. The most relevant predictor variables in identifying SI from non-SI included free thyroxine (FT4), the total scores of Hamilton Depression Scale (HAMD), vocational status, and free triiodothyronine (FT3). Conclusion: Risk for SI among patients with MDD can be identified at an individual subject level by integrating demographic, clinical, and biological variables as possible as early during hospitalization (at admission).

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Section: Risk Factors Of Si Among Mddmentioning

confidence: 99%

<p>Identifying Suicidal Ideation Among Chinese Patients with Major Depressive Disorder: Evidence from a Real-World Hospital-Based Study in China</p>

Ge¹,

Jiang²,

Wang³

et al. 2020

NDT

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“…stress and frustration in life) (Aaltonen et al, 2016;Zhang et al, 2016;Buckner et al, 2017). From a biological perspective, abnormalities in the serotonergic (5-hydroxytryptamine, 5-HT) system (Picouto et al, 2015), dysregulation of the hypothalamicpituitary-adrenal axis (Ghaziuddin et al, 2014), and a genetic contribution (Kang et al, 2017) to the risk of suicide have been found. Based on neuroimaging perspective, the present study observed that the left DLPFC GMV reductions as a biological factor may play a role in suicidal ideation in depression.…”

mentioning

confidence: 99%

Dorsolateral and ventrolateral prefrontal cortex structural changes relative to suicidal ideation in patients with depression

Zhang

Wei

Chang

et al. 2020

Acta Neuropsychiatr.

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The prefrontal cortex (PFC) is enormously important in suicide and major depressive disorder (MDD). However, little is known about the structural alterations in the brains of people with MDD and suicidal ideation. We examined the gray matter volume (GMV) of the PFC of individuals with MDD and suicidal ideation to determine if PFC volumetric differences contribute to suicidal ideation in patients with MDD. Thirty-five subjects with MDD and suicidal ideation, 38 subjects with MDD but without suicidal ideation, and 43 age- and gender-matched healthy control (HC) subjects underwent T1-weighted imaging. A voxel-based morphometric analysis was conducted to compare the PFC GMVs of the three groups. Further GMV reductions in the left and right dorsolateral PFC (DLPFC) and right ventrolateral PFC (VLPFC) were detected in the MDD with suicidal ideation group compared with those in the HC group and the MDD without suicidal ideation group, whereas the MDD without suicidal ideation group only exhibited significant differences in the left DLPFC relative to the HC group. Our findings demonstrated that left DLPFC reductions were associated with MDD and suicidal ideation, and diminished GMV reductions in the right DLPFC and right VLPFC were only associated with suicidal ideation. These results help us better understand the neuropathological changes in MDD with suicidal ideation.

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“…This scoping review contributes to research on peripheral and neural correlates of self-harm by summarizing data on children and adolescents ages 3 to 19 years, a demographic with social, developmental, and psychological characteristics of self-harm that can differ from those found in young adults [ 18 , 35 , 37 , 38 , 42 – 45 ]. Our work also advances knowledge on this topic by reviewing 79 studies in 76 publications, notably more studies than in earlier reviews and by covering 45 years from 1985 to 2020.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, adolescent hopelessness, loneliness, or impulsivity are less strongly related to self-harm than they are in adults [ 35 ]. Adolescents’ social risk factors are also different: parent-child conflict, school stressors, vicissitudes of early romantic relationships, victimization from bullying, and internet addiction and stress [ 37 , 45 ]. These factors may affect associations between self-harm and biological correlates differently in children and adolescents than in young adults.…”

Section: Introductionmentioning

confidence: 99%

Peripheral and neural correlates of self-harm in children and adolescents: a scoping review

et al. 2022

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Background Self-harm in children and adolescents is difficult to treat. Peripheral and neural correlates of self-harm could lead to biomarkers to guide precision care. We therefore conducted a scoping review of research on peripheral and neural correlates of self-harm in this age group. Methods PubMed and Embase databases were searched from January 1980-May 2020, seeking English language peer-reviewed studies about peripheral and neural correlates of self-harm, defined as completed suicide, suicide attempts, suicidal ideation, or non-suicidal self-injury (NSSI) in subjects, birth to 19 years of age. Studies were excluded if only investigating self-harm in persons with intellectual or developmental disability syndromes. A blinded multi-stage assessment process by pairs of co-authors selected final studies for review. Risk of bias estimates were done on final studies. Results We screened 5537 unduplicated abstracts, leading to the identification of 79 eligible studies in 76 papers. Of these, 48 investigated peripheral correlates and 31 examined neural correlates. Suicidality was the focus in 2/3 of the studies, with NSSI and any type of self-harm (subjects recruited with suicidality, NSSI, or both) investigated in the remaining studies. All studies used observational designs (primarily case-control), most used convenience samples of adolescent patients which were predominately female and half of which were recruited based on a disorder. Over a quarter of the specific correlates were investigated with only one study. Inter-study agreement on findings from specific correlates with more than one study was often low. Estimates of Good for risk of bias were assigned to 37% of the studies and the majority were rated as Fair. Conclusions Research on peripheral and neural correlates of self-harm is not sufficiently mature to identify potential biomarkers. Conflicting findings were reported for many of the correlates studied. Methodological problems may have produced biased findings and results are mainly generalizable to patients and girls. We provide recommendations to improve future peripheral and neural correlate research in children and adolescents, ages 3-19 years, with self-harm.

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The role of serotonin in adolescent suicide: theoretical, methodological, and clinical concerns

Cited by 13 publications

References 32 publications

<p>Identifying Suicidal Ideation Among Chinese Patients with Major Depressive Disorder: Evidence from a Real-World Hospital-Based Study in China</p>

<p>Identifying Suicidal Ideation Among Chinese Patients with Major Depressive Disorder: Evidence from a Real-World Hospital-Based Study in China</p>

Dorsolateral and ventrolateral prefrontal cortex structural changes relative to suicidal ideation in patients with depression

Peripheral and neural correlates of self-harm in children and adolescents: a scoping review

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