The Role of Serum Alpha-Amylase and Glycogen Synthase in the Anti-Diabetic Potential of Terminalia catappa Aqueous Leaf Extract in Diabetic  Wistar Rats

Ben, Ezekiel E.; Asuquo, Asuquo E.; Owu, Daniel U.

doi:10.9734/ajrimps/2019/v6i230096

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…We know insulin suppresses glycogenolysis and gluconeogenesis in the liver while promoting glycogen synthesis. Insulin enhances glycogen production and glycolysis in muscle by stimulating the facilitated transfer of glucose via the GLUT4 glucose transporter 30 . The oral administration of aqueous extract increased hepatic glycogen content in diabetic rats.…”

Section: Changes In Antioxidant Enzymes and Oxidative Stress Markersmentioning

confidence: 99%

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2023

IJPSR

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This work aimed to explore how crude aqueous extract of Jussiaea repens affected oxidative stress and metabolic status in streptozotocin (STZ) induced diabetic male rats. The diabetic rats were gavaged with aqueous extract of Jussiaea repens (50 mg/100 g body weight/day for 32 daysconsicutively) after an induction of STZ (8 mg/100g body weight, i.p.). Fasting blood glucose, insulin, serum LDH, total GSH, MDA, G-6-PDH, amylase, lipase, catalase and superoxide dismutase were measured. The hepatic levels of hexokinase, PFK, G-6-Pase, F-1,6-BPase and glycogen were also measured. The aqueous extract of Jussiaea repens decreased blood glucose level in diabetic control group. The extract supplemented group also demonstrated a notable improvement in blood insulin levels, SOD, GSH and G-6-PDH level in comparison to diabetic group. In diabetic group, the LDH and MDA levels were significantly higher than non-diabetic control rats and were significantly recovered in extract supplemented group. But catalase level showed no significant change. The liver glycogen, hexokinase and PFK were lower in the diabetic group, whereas G-6-Pase and F-1,6-BPase were higher, showing statistical recovery in the extract-treated group. Serum amylase and lipase followed the pattern of recovery like G-6-Pase and F-1,6-BPase. These findings suggested that aqueous extract of Jussiaea repens could regulate diabetes mellitus and oxidative stress in diabetics. This work will aid in the development of cheap herbal medicine for the amelioration of diabetes mellitus in future.

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Section: Changes In Antioxidant Enzymes and Oxidative Stress Markersmentioning

confidence: 99%

Untitled

2023

IJPSR

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“…The use of medicinal plant in management of diseases have been advocated by WHO [21] and this has instigated many research interests to develop alternative medicine to sustain human race in the face of disease and drug availability challenges. Terminalia catappa have been reported by many researchers and our team as useful antidiabetic [22], anti-inflammatory [23] and anti-oxidative [24] agents. This study seeks to investigate the atherogenic indices in diabetic rats treated with aqueous and methanol extracts of Terminalia catappa leaves in diabetic rats.…”

Section: Introductionmentioning

confidence: 98%

Assessment of atherogenic indices and modification of lipid profiles by aqueous and methanol extracts of Terminalia catappa leaves in diabetic rats

Ezekiel E. Ben,

Roseline Ateb,

Asuquo E. Asuquo

et al. 2024

World J. Adv. Res. Rev.

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Atherogenic indices are useful markers for prediction of cardiovascular diseases. This study investigates atherogenic indices in diabetic rats treated with different fractions of Terminalia catappa leaf extract. A total of Forty-two [42] male Wistar rats were randomly shared into 7 groups of 6 rats per group. Group 1 [control] received 5 ml/kg body weight of distilled water orally. Group 2 was treated with aqueous leaf extract of T. catappa at 130 mg/kg body weight orally while Group 3, diabetic untreated group orally received distilled water, 5ml/Kg body weight. Groups 4 and 5 were diabetic rats treated respectively with 130 mg/Kg body weight of aqueous leaf extract of T. catappa and subcutaneous administration of insulin, 0.75 U/Kg body weight. Group 6 received methanol fraction of T. catappa leaf extract; 130 mg/Kg body weight and group 7 was administered orally with 30 mg/Kg body weight of aspirin. Diabetes was induced with streptozotocin; 65 mg/Kg body weight. Results showed significant [p < 0.05] increase in TC, TG, LDL-c and VLDL-c in diabetic untreated group and significant reduction in HDL-c. These lipids were reduced and HDL-c increased significantly [p < 0.05] in aqueous and methanol extracts of T. catappa leaves treated groups. There was significant [p< 0.05] Fasting Blood Glucose reduction in both fractions. Therefore, modifications of lipid profile and reduction of atherogenic index in diabetic rats were similar in aqueous and methanol extracts of T. catappa leaves suggesting the potentials of preventing cardiovascular complications in diabetes mellitus.

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Antidiabetic effects of aqueous leaf extract of Vernonia amygdalina on serum liver markers in streptozotocin-induced diabetic albino Rats: a new data to support its Anti-diabetic effect

Adekemi,

Folake,

Omowumi

2024

Clin Phytosci

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Background Numerous plants have been explored for their potential antidiabetic properties, and Vernonia amygdalina (VA) stands among them. This study aims to investigate the antidiabetic activities of VA and validate its efficacy. Methods An aqueous extract of Vernonia amygdalina leaves was obtained through maceration. The antidiabetic effects of this plant extract were evaluated in vivo using diabetic model rats. Albino Wistar rats were induced into a diabetic state through intraperitoneal injection of streptozocin and subsequently treated with an optimal dose of 250 mg/kg aqueous extract of VA over a 21-day period. Parameters such as body weight, blood glucose levels, and serum marker enzymes were measured. Results The results demonstrated a significant reduction (p < 0.05) in the glucose levels of streptozocin-induced diabetic rats following treatment with VA extract, highlighting its potential as an antidiabetic agent that performed comparably to the reference drug, glimepiride. Additionally, a significant increase (p < 0.05) in the body weight of the treated diabetic rats was observed. Aqueous extracts also significantly (p < 0.05) altered the serum concentrations of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in a manner similar to the glimepiride-treated group. Conclusion This study affirms the anti-diabetic effects of the aqueous extract of Vernonia amygdalina in streptozotocin-induced diabetic rats and suggests that the extract holds promise as an important phytomedicine for the development of more effective treatments for diabetes.

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The Role of Serum Alpha-Amylase and Glycogen Synthase in the Anti-Diabetic Potential of Terminalia catappa Aqueous Leaf Extract in Diabetic Wistar Rats

Cited by 4 publications

References 35 publications

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Assessment of atherogenic indices and modification of lipid profiles by aqueous and methanol extracts of Terminalia catappa leaves in diabetic rats

Antidiabetic effects of aqueous leaf extract of Vernonia amygdalina on serum liver markers in streptozotocin-induced diabetic albino Rats: a new data to support its Anti-diabetic effect

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