The Role of Serum Anti-Mullerian Hormone Measurement in the Diagnosis of Polycystic Ovary Syndrome

Sivanandy, Mala S.; Ha, Sierra

doi:10.3390/diagnostics13050907

Cited by 9 publications

(5 citation statements)

References 93 publications

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“…In addition, Anti-Mullerian hormone (AMH) is a unique dimeric glycoprotein and also plays an important role in the pathophysiology of PCOS. Women with PCOS are noted to have higher levels of AMH and increased levels of serum AMH correlate highly with PCOS, polycystic ovarian morphology, hyperandrogenism, and oligo/amenorrhea ( 51 , 52 ). Serum AMH has potentially important values in the diagnosis and evaluation of PCOS.…”

Section: Discussionmentioning

confidence: 99%

Marrow adipose tissue is increased in overweight and obese women with PCOS independently of hyperandrogenism related obesity and metabolic disorders

Min

et al. 2023

Front. Endocrinol.

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PurposeThis study aimed to investigate the increase in bone marrow adipose tissue (BMAT) in overweight and obese women with polycystic ovary syndrome (PCOS) and its relationship with hyperandrogenism, obesity, and metabolic disorders.MethodsThe study included 87 overweight or obese women with PCOS (mean age 29 ± 4 years), as well as 87 age-matched controls recruited from a separate population study. All PCOS patients were measured for anthropometric features, abdominal adipose tissue areas, BMAT, biochemistry, and sex hormones. BMAT was compared between the PCOS patients and controls. In PCOS patients, subgroup comparisons of BMAT and its associations with body adiposity indices, biochemistry, and sex hormones were analyzed. The odds ratios (ORs) of elevated BMAT (defined as BMAT ≥ 38%) were calculated.ResultsOn average BMAT was increased by 5.6% ( ± 11.3%) in PCOS patients compared to controls. BMAT were significantly higher in the upper tertiles of total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C). BMAT was not correlated with abdominal adiposity indices or biochemistry except for LDL-C (r = 0.253—0.263, p = 0.014—0.018). LDL-C was not significantly different between the normal and abnormal androgen PCOS subgroups (p = 0.10-0.887). LDL-C, follicle stimulating hormone (FSH), and total testosterone (TT) were risk factors for elevated BMAT, with ORs of 1.899 (p = 0.038-0.040), 1.369 (p = 0.030-0.042), and 1.002 (p = 0.040-0.044) for each unit increase, respectively.ConclusionBMAT was increased in overweight and obese PCOS patients, but the increase in BMAT was not associated with the hyperandrogenism related obesity or metabolic disorders.

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Section: Discussionmentioning

confidence: 99%

Marrow adipose tissue is increased in overweight and obese women with PCOS independently of hyperandrogenism related obesity and metabolic disorders

Min

et al. 2023

Front. Endocrinol.

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“…Elevated T levels have a greater correlation with increased AHM levels than other types of androgens ( 23 ). Considering the close relationship between HA and AMH, AMH is used to evaluate the degree of HA and is considered an alternative to diagnosing PCOS, although the cutoff values are inconsistent ( 24 ). Additionally, AMH has been reported to stimulate GnRH and LH release; however, how AMH modulates GnRH function remains largely unknown.…”

Section: Neuroendrocine Abnormalitiesmentioning

confidence: 99%

Androgen excess: a hallmark of polycystic ovary syndrome

Wang,

Li,

Chen

2023

Front. Endocrinol.

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Polycystic ovarian syndrome (PCOS) is a metabolic, reproductive, and psychological disorder affecting 6–20% of reproductive women worldwide. However, there is still no cure for PCOS, and current treatments primarily alleviate its symptoms due to a poor understanding of its etiology. Compelling evidence suggests that hyperandrogenism is not just a primary feature of PCOS. Instead, it may be a causative factor for this condition. Thus, figuring out the mechanisms of androgen synthesis, conversion, and metabolism is relatively important. Traditionally, studies of androgen excess have largely focused on classical androgen, but in recent years, adrenal-derived 11-oxygenated androgen has also garnered interest. Herein, this Review aims to investigate the origins of androgen excess, androgen synthesis, how androgen receptor (AR) signaling mediates adverse PCOS traits, and the role of 11-oxygenated androgen in the pathophysiology of PCOS. In addition, it provides therapeutic strategies targeting hyperandrogenism in PCOS.

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“…17,18 CLINICAL FEATURES SYMPTOMS PCOS affects both adolescents and adult women, which is a condition with a variety of distinct manifestations. 19 Patients apply to the clinics with various symptoms that affect their physical appearance and quality of daily life.…”

Section: Adipose Tissue Dysfunctionmentioning

confidence: 99%

“…20 This includes gynecological symptoms such as oligomenorrhea, amenorrhea, and infertility as well as dermatological symptoms including hirsutism, acne, and alopecia. 19…”

Section: Adipose Tissue Dysfunctionmentioning

confidence: 99%

Polycystic ovary syndrome

Aydın,

Dayan,

Güngör

2023

JCOGP

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Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. It is characterized by a combination of hormonal imbalances, ovarian dysfunction, and metabolic disturbances. PCOS has significant implications for women's health, fertility, and overall well-being. This comprehensive review aims to provide an overview of PCOS, including its etiology, clinical manifestations, diagnosis, and management strategies.

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The Role of Serum Anti-Mullerian Hormone Measurement in the Diagnosis of Polycystic Ovary Syndrome

Cited by 9 publications

References 93 publications

Marrow adipose tissue is increased in overweight and obese women with PCOS independently of hyperandrogenism related obesity and metabolic disorders

Marrow adipose tissue is increased in overweight and obese women with PCOS independently of hyperandrogenism related obesity and metabolic disorders

Androgen excess: a hallmark of polycystic ovary syndrome

Polycystic ovary syndrome

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