The role of serum anti-Müllerian hormone (AMH) in the hormonal diagnosis of polycystic ovary syndrome

Casadei, Luisa; Madrigale, Alessandra; Puca, Francesco; Manicuti, Claudia; Emidi, Emanuela; Piccione, Emilio; Dewailly, Didier

doi:10.3109/09513590.2013.777415

Cited by 44 publications

(25 citation statements)

References 22 publications

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“…AMH at low concentrations is a marker of insufficient ovarian reserve, usually associated with advancing age (22), but high AMH concentrations are emerging as an important player in androgen-related anovulation in young women and are highly related to antral follicle number (23)(24)(25). Although our finding of higher AMH levels in the younger women would be expected, the relationship between increasing testosterone and increasing AMH persisted after adjustment for age.…”

Section: Discussioncontrasting

confidence: 73%

Increased Androgen, Anti-Müllerian Hormone, and Sporadic Anovulation in Healthy, Eumenorrheic Women: A Mild PCOS-Like Phenotype?

Sjaarda

Kissell

Schliep

et al. 2014

The Journal of Clinical Endocrinology &Amp; Metabolism

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Section: Discussioncontrasting

confidence: 73%

Increased Androgen, Anti-Müllerian Hormone, and Sporadic Anovulation in Healthy, Eumenorrheic Women: A Mild PCOS-Like Phenotype?

Sjaarda

Kissell

Schliep

et al. 2014

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…However, most authors agree that the AMH level is useful in the diagnosis of PCOS. The published AMH cutoffs range from 2.8 to 10.7 ng/ml [5,14,15,16]; a recent meta-analysis has suggested that a cutoff of 4.7 ng/ml [17] was appropriate in adults.…”

Section: Discussionmentioning

confidence: 99%

Do the Anti-Müllerian Hormone Levels of Adolescents with Polycystic Ovary Syndrome, Those Who Are at Risk for Developing Polycystic Ovary Syndrome, and Those Who Exhibit Isolated Oligomenorrhea Differ from Those of Adolescents with Normal Menstrual Cycles?

Savaş‐Erdeve

Keskin²,

Sağsak³

et al. 2016

Horm Res Paediatr

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Background/Aims: We aimed to investigate whether the anti-Müllerian hormone (AMH) levels in adolescents with polycystic ovary syndrome (PCOS), PCOS risk, and isolated oligomenorrhea (OM) were different than in adolescents with a normal/regular menstrual cycle (NMC). Methods: The diagnosis of PCOS was based on the 2012 Amsterdam [European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine (ESHRE/ASRM)] criteria. The PCOS group consisted of cases meeting 3 diagnostic criteria (n = 21), and the PCOS risk group was the ‘at risk' group meeting 2 diagnostic criteria (n = 20). Cases with isolated OM that did not satisfy other PCOS diagnostic criteria made up the OM group (n = 21). Thirty adolescent girls with NMCs (21-45 days) were recruited in this study. Results: The AMH levels in the PCOS group were similar to those in the PCOS risk group but significantly higher than those in the OM and NMC groups. The AMH levels in the PCOS risk group were similar to those in the OM group and significantly higher than those in the NMC group. They were also significantly higher in the OM group compared to the NMC group. The specificity for PCOS and PCOS risk with a cutoff value of 7.25 ng/ml for AMH was 72.5% and the sensitivity was 58%. Conclusion: An AMH cutoff value of 7.25 ng/ml can be used for the diagnosis of PCOS in the adolescent period.

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“…Accordingly, several threshold AMH values for PCOS (based on measurements among varied age and ethnic groups) have been proposed. Of note, serum AMH has been considered as a substitute for antral follicle count as articulated by the Rotterdam diagnostic criteria for PCOS (4)(5)(6)(7)(8)(9)(10)(11)(12) although this has not been widely used perhaps due to the lack of a universally standardized AMH serum assay (13).…”

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confidence: 99%

Age related endocrine patterns observed in polycystic ovary syndrome patients vs. ovulatory controls: descriptive data from a university based infertility center

Rashidi

Gorginzadeh

Aalipour

et al. 2016

Arch. Endocrinol. Metab.

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Objective: To compare serum anti-Müllerian hormone (AMH) and other endocrine parameters between patients diagnosed with polycystic ovary syndrome (PCOS) and age-matched ovulatory women. Materials and methods: AMH, DHEAS, FSH, LH, PRL, TSH and total testosterone (TT) were prospectively measured in oligo-ovulatory PCOS patients (n = 595) and in ovulatory non-PCOS women (n = 157) referred to a tertiary infertility center. Mean BMI was similar across the two study populations and there were no smokers in the sample. Patients in both groups were further classified into three categories by age: < 25 yrs, 25-34 yrs, and ≥ 35 yrs. Selected clinical and demographic characteristics were tabulated for each group. Results: Serum AMH was significantly higher among PCOS patients compared to non-PCOS controls in the non-stratified sample (7.54 ± 5.8 vs. 2.49 ± 2.0 ng/mL, respectively; p < 0.0001), while serum FSH, DHEAS, TSH and prolactin were similar for both groups (p > 0.05). As expected, mean (total) testosterone levels were notably different between PCOS vs. non-PCOS controls (0.84 ± 0.76 vs. 0.43 ± 0.38 ng/mL, respectively; p < 0.001), and mean AMH level was significantly lower in the oldest age category (> 35 yrs) compared to both younger control groups (p < 0.0001). Both DHEAS and total testosterone decreased with age among PCOS patients, although mean serum DHEAS for women age > 35 yrs was significantly lower than DHEAS measured in younger women with PCOS (p < 0.02). For PCOS patients, AMH remained relatively stable irrespective of age. Conclusion: Although AMH can serve as a satisfactory marker of ovarian reserve, for PCOS patients the expected decline in AMH associated with reproductive aging appears attenuated despite ovarian senescence. In contrast, mean DHEAS levels were markedly lower among older PCOS women (> 35 yrs) compared to younger PCOS patients. Arch Endocrinol Metab. 2016;60(5):486-91

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The role of serum anti-Müllerian hormone (AMH) in the hormonal diagnosis of polycystic ovary syndrome

Cited by 44 publications

References 22 publications

Increased Androgen, Anti-Müllerian Hormone, and Sporadic Anovulation in Healthy, Eumenorrheic Women: A Mild PCOS-Like Phenotype?

Increased Androgen, Anti-Müllerian Hormone, and Sporadic Anovulation in Healthy, Eumenorrheic Women: A Mild PCOS-Like Phenotype?

Do the Anti-Müllerian Hormone Levels of Adolescents with Polycystic Ovary Syndrome, Those Who Are at Risk for Developing Polycystic Ovary Syndrome, and Those Who Exhibit Isolated Oligomenorrhea Differ from Those of Adolescents with Normal Menstrual Cycles?

Age related endocrine patterns observed in polycystic ovary syndrome patients vs. ovulatory controls: descriptive data from a university based infertility center

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