The role of serum C-reactive protein in women with lower urinary tract symptoms

Hsiao, Sheng‐Mou; Lin, Ho‐Hsiung; Kuo, Hann‐Chorng

doi:10.1007/s00192-012-1715-1

Cited by 36 publications

(31 citation statements)

References 30 publications

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“…BACH survey also confirmed a consistent association of increasing CRP levels and OAB among both men and women [24]. In women with OAB-wet, higher serum CRP levels were also found and they were related to lower Qmax and higher body mass indices [25].…”

Section: Discussionsupporting

confidence: 54%

Increased Serum C-Reactive Protein Level Is Associated with Increased Storage Lower Urinary Tract Symptoms in Men with Benign Prostatic Hyperplasia

2014

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ObjectiveChronic inflammation is considered as one of the contributing mechanisms of lower urinary tract symptoms (LUTS). Serum C-reactive protein (CRP) level is the widely used biomarker of inflammatory status. This study investigated the association between serum CRP level in men with benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) before and after medical treatment.MethodsA total of 853 men with BPH and LUTS were enrolled. All patients completed the International Prostate Symptoms Score (IPSS) questionnaire and urological examinations. The parameters of uroflowmetry (maximum flow rate, Qmax; voided volume, VV), post-void residual (PVR), total prostate volume (TPV) and transition zone index (TZI), serum prostate specific antigen (PSA), and serum CRP levels were obtained. All patients were treated with alpha-blocker or antimuscarinic agent based on the IPSS voiding to storage subscore ratio (IPSS-V/S). Correlation analyses were performed between serum CRP levels with age, IPSS, TPV, TZI, Qmax, PVR, VV, PSA and between baseline and post treatment.ResultsThe mean age was 66.9±11.6 years old and the mean serum CRP levels were 0.31±0.43 mg/dL. Univariate analyses revealed serum CRP levels were significantly associated with age (p<0.001), PSA levels (p = 0.005) and VV (p = 0.017), but not significantly associated with TPV (p = 0.854) or PVR (p = 0.068). CRP levels were positively associated with urgency (p<0.001) and nocturia (p<0.001) subscore of IPSS, total IPSS (p = 0.008) and storage IPSS (p<0.001) and negatively associated with IPSS- V/S ratio (p = 0.014). Multivariate analyses revealed that serum CRP levels were significantly associated with age (p = 0.004) and storage IPSS subscore p<0.001). Patients with IPSS-V/S<1 and treated with tolterodine for 3 months had significant decrease of CRP levels after treatment.ConclusionSerum CRP levels are associated with storage LUTS and sensory bladder disorders, suggesting chronic inflammation might play a role in the patients with storage predominant LUTS.

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Section: Discussionsupporting

confidence: 54%

Increased Serum C-Reactive Protein Level Is Associated with Increased Storage Lower Urinary Tract Symptoms in Men with Benign Prostatic Hyperplasia

2014

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“…In this study, CRP was not as high as it was in the acute febrile bacterial infection [9]. As a result, in the light of the information obtained from other studies too, serum CRP levels are detected significantly higher in OAB-wet than all other conditions [4]. In the present study, it was determined that serum CRP levels significantly increased as urge incontinence increased in the patient group M A N U S C R I P T…”

Section: Discussionmentioning

confidence: 61%

“…It is produced by hepatocytes under the influence of cytokines such as interleukin-6 and tumor necrosis factor-α [4]. In the studies conducted on patients diagnosed with overactive bladder (OAB) and interstitial cystitis (IC), high CRP levels have been identified as a finding of inflammation.…”

Section: Introductionmentioning

confidence: 99%

C-reactive protein levels in girls with lower urinary tract symptoms

Tarhan¹,

Ekin²,

Can³

et al. 2016

Journal of Pediatric Urology

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“…Higher values of the maximum urinary flow rate and the body mass index turned out to be two independent factors affecting the CRP level. It was also proven that a CRP level of 1-3 mg/L entailed an increase in the risk of OAB symptoms, which might suggest that the inflammatory process plays an important role in the etiopathogenesis of OAB [7].…”

Section: Crp and Cytokinesmentioning

confidence: 99%

Novel biomarkers of overactive bladder syndrome

et al. 2017

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The social aspect of overactive bladder syndrome (OAB) and the lack of objective diagnostic methods for this syndrome have spurred research into its potential biomarkers which can constitute useful diagnostic tools, while also allowing the evaluation of the intensity of clinical symptoms and the efficacy of implemented pharmacotherapy in OAB patients. Due to the complex etiopathogenesis of this syndrome, the researchers are seeking biomarkers connected with inflammation or nerve growth. The aim of this review was to analyse the latest literature data regarding potential biomarkers in OAB. The most promising opportunities are connected with the diagnostic use of the nerve growth factor (NGF), the brain derived neurotrophic factor (BDNF), C-reactive protein (CRP), prostaglandins and cytokines. Despite the most promising results to date having been obtained with regards to neurotrophic factors, it seems that, at the moment, none of these meets the criteria for becoming an isolated OAB marker. It is also suggested that the combined use of several biomarkers will facilitate obtaining the appropriate level of specificity and selectivity to allow their use in clinical practice.

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The role of serum C-reactive protein in women with lower urinary tract symptoms

Abstract: High serum CRP levels were found in women with OAB wet, and they were related to lower maximum urinary flow rates and higher body mass indices in non-SUI LUTD. However, serum CRP is not a suitable biomarker for discriminating between subtypes of non-SUI LUTD.

Cited by 36 publications

References 30 publications

Increased Serum C-Reactive Protein Level Is Associated with Increased Storage Lower Urinary Tract Symptoms in Men with Benign Prostatic Hyperplasia

Increased Serum C-Reactive Protein Level Is Associated with Increased Storage Lower Urinary Tract Symptoms in Men with Benign Prostatic Hyperplasia

C-reactive protein levels in girls with lower urinary tract symptoms

Novel biomarkers of overactive bladder syndrome

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