The role of sex hormones on formalin-induced nociceptive responses

Gaumond, Isabelle; Arsenault, Pierre; Marchand, Serge

doi:10.1016/s0006-8993(02)03661-2

Cited by 149 publications

(90 citation statements)

References 23 publications

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“…These results are consistent with previous reports in which the onset of an arthritic state in male rats is associated with changes in paw volume, body weight, joint stiffness, and mechanical hyperalgesia (Millan et al, 1987;Nagakura et al, 2003). The increased nociceptive sensitivity in female arthritic rats is consistent with studies demonstrating that females are more sensitive than males to the nociceptive producing effects of the algogenic agents formalin and capsaicin (Aloisi et al, 1994;Gaumond et al, 2002;Barrett et al, 2003) and are in agreement with studies demonstrating that females develop a more severe arthritic state based on articular indices and gross observational measures (Wilder et al, 1982;Allen et al, 1983;Holmdahl, 1995).…”

Section: Discussionsupporting

confidence: 92%

“…Various algogenic agents, including capsaicin and formalin, can be used to produce an inflammatory condition that results in a persistent, prolonged nociceptive state. In rats injected with formalin in the hindpaw, females exhibit a significantly greater nociceptive response than males (Aloisi et al, 1994;Gaumond et al, 2002). Similarly, after intradermal tail administration of capsaicin, females exhibit a significantly greater hyperalgesic response to a water stimulus applied to the tail of the rat, and, unlike with acute tests, morphine is equally potent in reversing the hyperalgesic state in males and females .…”

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confidence: 93%

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Nociceptive Sensitivity and Opioid Antinociception and Antihyperalgesia in Freund's Adjuvant-Induced Arthritic Male and Female Rats

Cook

Nickerson²

2004

J Pharmacol Exp Ther

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The present study was designed to examine sex differences in complete Freund's adjuvant (CFA)-induced mechanical hyperalgesia and sex differences in opioid antinociception and antihyperalgesia. Female rats developed inflammation and hyperalgesia faster and exhibited greater peak hyperalgesia than male rats. In arthritic (CFA-treated) rats, lower thresholds were observed during estrus and proestrus, and in nonarthritic (vehicle-treated) rats, lower thresholds were observed during proestrus. Morphine and oxycodone were more potent in male than female arthritic rats, and butorphanol was more potent and effective in male than female arthritic rats. The potency of morphine was increased in arthritic rats, although to a greater magnitude in males. The potency of oxycodone was increased in male but not female arthritic rats. The potency of butorphanol was increased in arthritic male rats and the maximal antinociceptive effect of butorphanol was increased in arthritic female rats, but it did not result in greater than 20% antinociception. Morphine, oxycodone, and butorphanol all produced antihyperalgesic effects (returning thresholds of arthritic rats to the thresholds of nonarthritic rats) with greater potency in males than females. The peripherally acting opioid agonist loperamide produced intermediate levels of antinociception in male and female arthritic rats and no antinociception in nonarthritic rats. Loperamide was more potent in male than female arthritic rats at producing antihyperalgesia. These data demonstrate sex differences in arthritis-induced hyperalgesia and responsiveness to opioid analgesics. In arthritic rats, the antinociceptive effects of opioid agonists are most probably mediated by both central and peripheral opioid receptors, whereas their antihyperalgesic effects are mediated primarily by actions at peripheral opioid receptors.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 93%

Nociceptive Sensitivity and Opioid Antinociception and Antihyperalgesia in Freund's Adjuvant-Induced Arthritic Male and Female Rats

Cook

Nickerson²

2004

J Pharmacol Exp Ther

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“…11 The varied responses reported in this study highlights how individual factors and social and cultural norms can have a profound effect on perception and expression of pain. [12][13][14] The findings in this study corroborated previous research on HCPs perspectives on pain expression among BU patients, that some patients suppressed their pain, whereas others would exaggerate it. 10 It is possible that the patients who overtly expressed their pain by crying were perceived as exaggerating their pain.…”

Section: Discussionsupporting

confidence: 88%

Experiences of Pain and Expectations for Its Treatment Among Former Buruli Ulcer Patients

Woolley

Velink

Phillips

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Buruli ulcer (BU) is one of the 17 neglected tropical diseases for which the World Health Organization has adopted resolutions to improve treatment. BU was previously described as a relatively painless condition; however, recent research has indicated that some patients experience substantial pain. The objective of this study was to explore patients' experiences of pain and their expectations for its treatment. Semistructured interviews were conducted in a BU-endemic region of Ghana. Interviews were held with former BU patients (N = 20) and community controls (N = 19). Former patients were asked about BU-related pain and their expectations for its treatment. The interviews were conducted in October 2014, and were audiotaped, translated and transcribed into English, and then qualitatively analyzed. Of the 20 former BU patients interviewed, 19 (95%) reported experiencing pain, with patients reporting pain as a consequence of the ulcer and wound management. Some participants expressed pain through crying, whereas others did not openly express pain, sometimes because they feared the repercussions of doing so. Patients wanted to receive pain relief; however, many were unable to name a medication. Nonpharmaceutical options were cited as being an alternative. Many BU patients experience pain; however, former patients and community members alike appear to have a limited knowledge about available pain relief. A low-cost alternative to medication may be the use of nonpharmaceutical means for pain relief. Routine pain assessment may reduce patients' fear and unwillingness to express pain. Awareness of such issues will be valuable when implementing a BU pain relief guideline.

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“…Evidence for organizational versus activational effects of gonadal hormones on pain traits is mixed, with some studies showing robust effects of neonatal male castration and female testosterone-induced masculinization on pain behaviour [66][67][68][69][70] and others being strongly supportive of the primacy of circulating hormone levels in the adult [71][72][73][74][75][76][77] . The classic organizational versus activational dichotomy has recently been supplemented by the realization that direct genetic effects are possible as well: traits such as pain might be affected by genes on the Y chromosome, X-linked genes escaping inactivation, parentally imprinted genes and/or allelic mosaicism 78 .…”

Section: Nature Reviews | Neurosciencementioning

confidence: 99%

Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon

2012

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| A clear majority of patients with chronic pain are women; however, it has been surprisingly difficult to determine whether this sex bias corresponds to actual sex differences in pain sensitivity. A survey of the currently available epidemiological and laboratory data indicates that the evidence for clinical and experimental sex differences in pain is overwhelming. Various explanations for this phenomenon have been given, ranging from experiential and sociocultural differences in pain experience between men and women to hormonally and genetically driven sex differences in brain neurochemistry. PERSPECTIVES NATURE REVIEWS | NEUROSCIENCE VOLUME 13 | DECEMBER 2012 | 859

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The role of sex hormones on formalin-induced nociceptive responses

Cited by 149 publications

References 23 publications

Nociceptive Sensitivity and Opioid Antinociception and Antihyperalgesia in Freund's Adjuvant-Induced Arthritic Male and Female Rats

Nociceptive Sensitivity and Opioid Antinociception and Antihyperalgesia in Freund's Adjuvant-Induced Arthritic Male and Female Rats

Experiences of Pain and Expectations for Its Treatment Among Former Buruli Ulcer Patients

Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon

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