The Role of Sex Steroids in Angiogenesis

Lam, Yuen Ting; Lecce, Laura; Bursill, Christina A.; Ng, M.

doi:10.1007/978-3-319-61115-0_20

Cited by 1 publication

(1 citation statement)

References 139 publications

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“…A peak in the serum testosterone level during the first year of life is followed by a return to basal levels and another significant rise at puberty, followed by adult hormone levels. This peak at first age and its phenotypic result is called “mini-puberty.” The structural changes of the prepuce were concordant with changes in serum androgen levels reported in previous studies [ 18 19 20 ]. Our results provide significant clues about the concordance of androgen levels and structural changes of the prepuce.…”

Section: Discussionsupporting

confidence: 90%

Histological and morphological development of the prepuce from birth to prepubertal age

Erdem,

Caliskan,

Karagul

et al. 2024

Investig Clin Urol

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Purpose To study the histological changes of the preputial tissue from birth to prepubertal age in order to define unnoticed morphological changes. Materials and Methods Prepuce samples were obtained from 79 healthy boys who underwent routine ritual circumcision. Specimens were divided into six groups according to the boys’ age: newborn, 0–1 year of age, 2–3 years of age, 4–5 years of age, 6–7 years of age, and 8–9 years of age. Histologic analysis of the specimens was performed by H&E, Masson’s trichrome, Verhoeff–Von Gieson, immunohistochemical staining. Results Microscopic examinations showed that average epithelial thickness increased after the neonatal period (p=0.001). When collagen fiber density was evaluated, no significant differences between groups were found (p=0.083). When the elastic fibers in the dermis were evaluated, it was determined that the number and thickness of elastic fibers increased with age. Immunohistochemical examinations showed that the number of peripheral nerves marked with S100 was lower in the neonatal period than at other ages (p=0.048). When the vessels marked with CD105 antibody were counted, there was no significant difference between the groups (p=0.078). Conclusions This is the first study to examine the age-related structure of connective tissue elements in the foreskin. Our results showed that the prepuce’s prepubertal maturation process is continuous, and the first 2 years of life are appropriate not only in relation to the physiological effects of age but also the optimum structural changes for wound healing, such as vessel diameter, epithelium thickness, peripheral nerve count.

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Section: Discussionsupporting

confidence: 90%