The role of sildenafil citrate (viagra) suppositories on endometrial response (thickness and mean resistance index of endometrial spiral artery) in cases of unexplained infertility

Elshourbagy, S; Ossman, Ahmed M. E.; El-Mohamady, Ashraf

doi:10.4103/1110-2098.215451

Cited by 7 publications

(6 citation statements)

References 5 publications

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“…These results were matched with Hashad et al; they concluded that the mean age of women in the study group was 26 years while in the control group was 27 years [8]. El-Shourbagy et al concluded that as regards the age there was no significant difference between fertile and infertile groups [3].…”

Section: Discussionsupporting

confidence: 78%

“…Unexplained infertility is defined as failure of couple to achieve pregnancy without presence of definite cause after 12 months of trying conception, or after 6 months in female more than or equal 35 years old [3]. Ten to twenty five percent (10-25%) of infertile females had no definite cause for infertility and diagnosed with unexplained infertility [2].…”

Section: Introductionmentioning

confidence: 99%

“…Adequate blood flow of uterus is important for good endometrial growth and increase the endometrial receptivity [5]. Increased impedance of uterine arteries' blood flow leads to poor growth of endometrium and endometrial thinning [3].…”

Section: Introductionmentioning

confidence: 99%

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Role of uterine artery Doppler in assessment of unexplained infertility

Zarad

Mohamed

Shanab

2021

Egypt J Radiol Nucl Med

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Background The study aimed to compare the values of uterine artery Doppler indices including resistance index (RI), pulsatility index (PI), and systolic/diastolic (S/D) ratios in fertile female and female with unexplained infertility and investigate their association with unexplained infertility. This study included 70 women divided into two groups. Study group included 40 women with unexplained infertility and control group included 30 fertile women. Results The mean ages of study and control groups were 26.9 and 28.5 years respectively. In infertile group, the mean values of uterine arteries resistance index (RI), pulsatility index (PI), and systolic/diastolic (S/D) ratios were 0.9, 2.9, and 8.0 respectively. In the fertile control group, mean RI and PI values and S/D ratio were 0.6, 1.5, and 2.7 respectively. There was statistically significant difference as regards RI, PI, and S/D ratios between study and control groups. The best cut off values of RI, PI, and S/D ratios for predicting increased uterine blood flow impedance were more than 0.67, 1.95, and 3 respectively with sensitivity of 100%, 95%, and 100% respectively, specificity of 96.7%, 86.7%, and 96.7% respectively, and diagnostic accuracy of 98.6%, 91.42%, and 98.57% respectively. Conclusion Uterine artery Doppler indices mean values were higher in unexplained infertility women than fertile women. Uterine artery Doppler indices have high sensitivity and specificity for diagnosis of high uterine blood flow impedance. High uterine blood flow impedance diagnosed by uterine artery Doppler may contribute in the etiology of unexplained infertility. Uterine artery Doppler should be included in investigation of unexplained infertility.

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Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

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Role of uterine artery Doppler in assessment of unexplained infertility

Zarad

Mohamed

Shanab

2021

Egypt J Radiol Nucl Med

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“…For a prospective study on fifty patients with unexplained 1ry infertility, El-Shourbagy et al [16] were conclude that the patients treated with sildenafil citrate saw a statistically significant increase in endometrial thickness and a higher pregnancy rate than control group. In addition , our result showed that there was no statically significant difference between the studied group in fetal pulse detection , sildanfil group 5 cases of 6 (83.3%) positive fetal heart beat but Estradiol group 6 cases of 7(85.7%) positive fetal heart beat (P = 0.9 ).…”

Section: Dawood Et Al [3]mentioning

confidence: 98%

Effect of Vaginal Sildenafil versus Oral Estradiol Valerate on Endometrial Thickness and Pregnancy Rate in infertile Women Undergoing Induction of Ovulation by Clomiphen Citrate

El-Asbaa

Sarhan

Soliman

et al. 2021

Zagazig University Medical Journal

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Background: Endometrial thickness (ET) is one of the best predictors of implantation rate and continued success rate for pregnancy. There were possible beneficial effects of sildenafil citrate or estradiol on endometrial receptivity. The aim of this study was to compare the effect of Vaginal Sildenafil versus Oral Estradiol Valerate on Endometrial Thickness and Pregnancy Rate in infertile women undergoing induction of ovulation by clomiphen citrate. Patients and Methods: This Randomized control study was conducted on 44 infertile women undergoing induction by Clomiphen Citrate attending infertility and

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“…For a prospective study on fifty females with unexplained primary infertility, El-Shourbagy et al were administered sildenafil citrate suppositories 25 mg of 4 times daily for 7 days. Patients treated with sildenafil citrate demonstrate a significant rise in endometrial thickness and a higher pregnancy outcome compare with the control group receiving no treatment (El-Shourbagy, et al [19] ). [20] ).…”

Section: Endometrial Receptivity and Pregnancy Ratementioning

confidence: 99%

A Comparison Between the Effect of Vaginal Sildenafil Versus Oral Estradiol Valerate on Ultrasound Parameters of Endometrial Receptivity and Follicular Growth in Iraqi Females Receiving Letrozole for Induction of Ovulation

Dawood

Jwad

Hussaini

2020

IJEIR

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Endometrial thickness (ET) is one of the best predictors of implantation rate and pregnancy success rate because endometrial growth depends on hormones. Estrogen regulates the proliferative phase, endometrial proliferation induced by estrogen after menstruation is largely dependent on blood flow to the basal endometrium that produces progesterone receptors which are required for progesterone-regulated endometrial growth in the secretory process. To compare the effect of estradiol valerate vs. sildenafil citrate on endometrial receptivity and subsequent pregnancy outcome in unexplained infertility patients receiving letrozole for ovulation induction. Herein, 21 patients with unexplained infertility underwent ovulation induction by letrozole (2.5 mg). Patients were divided into 2 groups; group A (10 patients) were given sildenafil tablets vaginally (25 mg) four times daily and group B (11 patients) were treated with estradiol valerate tablet 2 mg/12 hours. Patients were evaluated by transvaginal ultrasonography (TVS) to determine endometrial thickness, pattern, size, and the number of the dominant follicles, serum assessment of Vascular Endothelial Growth Factor (VEGF) level at trigger day, and chemical pregnancy outcome 14 days later. Results showed that the endometrial thickness, patterns of the endometrium, VEGF, size of the dominant follicle at the trigger day, and pregnancy rates were not significantly different between the two groups. However, the difference in the number of the dominant follicles at trigger day was statistically significant which is more in the sildenafil treated group. The present study confirmed the findings of both Sildenafil and E2 valerate to boost endometrial receptivity and pregnancy rate.

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The role of sildenafil citrate (viagra) suppositories on endometrial response (thickness and mean resistance index of endometrial spiral artery) in cases of unexplained infertility

Cited by 7 publications

References 5 publications

Role of uterine artery Doppler in assessment of unexplained infertility

Role of uterine artery Doppler in assessment of unexplained infertility

Effect of Vaginal Sildenafil versus Oral Estradiol Valerate on Endometrial Thickness and Pregnancy Rate in infertile Women Undergoing Induction of Ovulation by Clomiphen Citrate

A Comparison Between the Effect of Vaginal Sildenafil Versus Oral Estradiol Valerate on Ultrasound Parameters of Endometrial Receptivity and Follicular Growth in Iraqi Females Receiving Letrozole for Induction of Ovulation

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