The role of silent helicobacter pylori infection in intragastric ulcers induced by balloon insertion used for management of obesity

Haydara, Tamer; Kabel, Ahmed M.; Elsaka, Ayman Mohamed

doi:10.1016/j.dsx.2018.08.023

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…Helicobacter pylori is one of the most common gastrointestinal pathogens that is associated with gastritis, gastroduodenal ulcer and mucosa‐associated lymphoid tissue (MALT) lymphoma (Ghazy et al, 2022; Haydara et al, 2017; Sun & Zhang, 2019). It alters the mucosal immune response, disturbs gastric acid secretions and causes direct mucosal irritation (Haydara et al, 2019). H. pylori is the first bacterium to be determined as carcinogenic (Gönen et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Association of human leukocyte antigen DQ-rs3920AG genotype with Helicobacter pylori recurrence in Kafrelsheikh, Egypt

Ghazy

Taha

2022

Journal of Applied Microbiology

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Aims:The aim was to evaluate the role of HLA-DP/DQ single-nucleotide polymorphisms (SNPs) in Helicobacter pylori infection in Kafrelsheikh governorate, Egypt. Methods and results:The study enrolled 120 persons; 48 naïve H. pylori-infected patients, 42 relapsers and 30 H. pylori-free controls. Gastroscopy, H. pylori stool antigen, anti-CagA and anti-VacA antibodies were determined. Genotyping of HLA-DPA1rs3077 (A/G) SNP and HLA-DQ-rs3920(A/G) SNP was done using real-time PCR. The antibody profile against H. pylori showed that 85.7% of patients with recurrent infection have IgG against CagA (p = 0.001*). There was a significant association between the occurrence of H. pylori infection and both HLA-DPA1rs3077AA and HLA-DQ-rs3920AG genotypes. Concerning H. pylori relapse, the HLA-DQ-rs3920AG genotype was detected in 78.6% of patients with recurrent infection (p = 0.002*).Patients carrying this genotype tend to be relapsers 9.8 times more than patients carrying other genotypes.Conclusions: HLA-DPA1rs3077AA and/or HLA-DQ-rs3920AG genotypes could be risk factors for the occurrence of H. pylori infection. HLA-DQ-rs3920AG genotype is markedly linked to recurrent H. pylori infection.Significance and impact of the study: Host factors as HLA gene polymorphism could be a predisposing factor for susceptibility, recurrence or chronicity of H. pylori and should be studied in different ethnic groups.

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Section: Introductionmentioning

confidence: 99%

Association of human leukocyte antigen DQ-rs3920AG genotype with Helicobacter pylori recurrence in Kafrelsheikh, Egypt

Ghazy

Taha

2022

Journal of Applied Microbiology

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“…Obesity is a serious condition and cause of significant morbidity and mortality. It increases the risk of type 2 diabetes, recurrent thromboembolism, AF, and acute coronary syndrome [ 6 ]. It is anticipated that by 2030, obese people will constitute more than half the general population and more than 10% will have morbid obesity (BMI > 40) [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Comparing the Efficacy and Safety of Apixaban Versus Warfarin in Morbidly Obese Patients

Alotaibi¹,

Hasan²,

Metwali³

et al. 2022

Cureus

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This study was conducted to evaluate the efficacy and safety of apixaban versus warfarin in morbidly obese patients. A total of 250 morbidly obese patients with a body mass index (BMI) higher than 40 kg/m 2 or a body weight higher than 120 kg who were on anticoagulation therapy with either apixaban or warfarin for over one month were included in the study. This retrospective cohort, multicenter study was executed using the medical records of 125 morbidly obese patients treated with apixaban, while patients on warfarin were selected using a systemic random sampling to match the sample size of the apixaban group. There was no significant difference between apixaban and warfarin in the development of thromboembolic events and major bleeding. However, incidences of minor bleeding significantly decreased in the apixaban group compared to patients treated with warfarin. This difference was overcome by controlling serum creatinine and nonsteroidal anti-inflammatory drugs (NSAIDs). In conclusion, apixaban efficacy and safety are nearly the same as that of warfarin in morbidly obese patients with a lower incidence of minor bleeding with apixaban. Controlling serum creatinine and NSAIDs use may improve warfarin safety and decrease its complications.

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The role of silent helicobacter pylori infection in intragastric ulcers induced by balloon insertion used for management of obesity

Cited by 2 publications

References 17 publications

Association of human leukocyte antigen DQ-rs3920AG genotype with Helicobacter pylori recurrence in Kafrelsheikh, Egypt

Association of human leukocyte antigen DQ-rs3920AG genotype with Helicobacter pylori recurrence in Kafrelsheikh, Egypt

Comparing the Efficacy and Safety of Apixaban Versus Warfarin in Morbidly Obese Patients

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