The role of sirtuin 1 in ageing and neurodegenerative disease: A molecular perspective

Thapa, Riya; Moglad, Ehssan; Afzal, Muhammad; Gupta, Gaurav; Bhat, Asif Ahmad; Hassan almalki, Waleed; Kazmi, Imran; Alzarea, Sami I.; pant, Kumud; Singh, Thakur Gurjeet; Singh, Sachin Kumar; Ali, Haider

doi:10.1016/j.arr.2024.102545

Ageing Research Reviews

2024

DOI: 10.1016/j.arr.2024.102545

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The role of sirtuin 1 in ageing and neurodegenerative disease: A molecular perspective

Riya Thapa,

Ehssan Moglad,

Muhammad Afzal

et al.

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2024

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Cited by 2 publications

References 173 publications

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The interplay of NAD and hypoxic stress and its relevance for ageing

Burtscher,

Denti,

Gostner

et al. 2024

Ageing Research Reviews

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The interplay of NAD and hypoxic stress and its relevance for ageing

Burtscher,

Denti,

Gostner

et al. 2024

Ageing Research Reviews

View full text Add to dashboard Cite

Proteomic analysis of adenosine, thiamine, niacin and cyanocobalamin synergetic neuroprotective effect in pathophysiology of diabetic polyneuropathy

Gromovа,

Torshin,

Moiseenok

2024

Farmakoèkonomika

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Background. Neurotransmitter adenosine and B-group vitamins are characterized by neuroprotective, remyelinizing and anti-neuroinflammatory properties. Despite the studies of these molecules for decades, the molecular mechanisms of their synergistic effect on neuroinflammation processes are unexplored and not systematized.Objective: To establish the molecular mechanisms of synergism of adenosine, thiamine, niacin and cyanocobalamin in counteracting the pathology of diabetic polyneuropathy (DPN).Material and methods. The molecular mechanisms of action of adenosine, thiamine (vitamin B1), niacin (vitamin PP) and cyanocobalamin (vitamin B12) in the pathophysiology of DPN were determined using functional analysis of genomic and proteomic databases.Results. As a result of the analysis of 20,180 annotated proteins of the human proteome, 504 vitamin-PP-dependent, 22 vitamin-B1-dependent, 24 vitamin-B12-dependent and 50 adenosine-dependent proteins were identified. The proteins of the human proteome were identified, the activity or levels of which are important for reducing neuroinflammation, remyelination, neurogenesis, biosynthesis of neuronal adenosine triphosphate, myelin homeostasis, neuroplasticity, neutralization of homocysteine, regeneration of nerve fibers and support of the endothelium of the microvascular bed.Conclusion. The established molecular mechanisms of synergism of the studied molecules are of fundamental importance for understanding the processes of neuroinflammation regulation and remyelination to prevent diabetic polyneuropathy and other neurodegenerative diseases.

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The role of sirtuin 1 in ageing and neurodegenerative disease: A molecular perspective

Cited by 2 publications

References 173 publications

The interplay of NAD and hypoxic stress and its relevance for ageing

The interplay of NAD and hypoxic stress and its relevance for ageing

Proteomic analysis of adenosine, thiamine, niacin and cyanocobalamin synergetic neuroprotective effect in pathophysiology of diabetic polyneuropathy

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