The role of Sirtuin 2 in sustaining functional integrity of the liver

Park, Sunyoung; Chung, Myung-Jin; Son, Jun‐Hyeok; Yun, Hyun Ho; Park, Jaemin; Yim, Jae-Hyuk; Jung, Seung-Jun; Lee, Sang‐Han; Jeong, Kyu‐Shik

doi:10.1016/j.lfs.2021.119997

Cited by 16 publications

(8 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sirt2 is an NAD+-dependent deacetylase that is widely involved in cell division, angiogenesis [48][49][50] , energy metabolism [51] and neurodegenerative [52,53] , cardiovascular disease [54,55] , oxidative stress [56] and many cancers [57,58] , etc. Studies have found that Sirt2 was the most abundant sirtuin expressed in mammalian CNS, especially in cortex, striatum, hippocampus, and spinal cord, suggesting that it might have a role in CNS [59] .…”

Section: Discussionmentioning

confidence: 99%

Label-free quantitative proteomics analyses of mouse astrocytes provides insight into the host response mechanism at different developmental stages ofToxoplasma gondii

Xie

Zhao

et al. 2023

Preprint

View full text Add to dashboard Cite

Toxoplasma gondii (T. gondii) is an opportunistic parasite that can infect the central nervous system (CNS), causing severe toxoplasmosis and behavioral cognitive impairment. Mortality is high in immunocompromised individuals with toxoplasmosis, most commonly due to reactivation of infection in the CNS. There are still no effective vaccines and drugs for the prevention and treatment of toxoplasmosis. There are five developmental stages for T. gondii to complete life cycle, of which the tachyzoite and bradyzoite stages are the key to the acute and chronic infection. In this study, to better understanding of how T. gondii interacts with the host CNS at different stages of infection, we constructed acute and chronic infection models of T. gondii in astrocytes, and used label-free proteomics to detect the proteome changes before and after infection, respectively. A total of 4676 proteins were identified, among which 163 differentially expressed proteins (DEPs) (fold change≥1.5 or ≤0.67 and p-value≤0.05) including 109 up-regulated proteins and 54 down-regulated proteins in C8-TA vs C8 group, and 719 DEPs including 495 up-regulated proteins and 224 down-regulated proteins in C8-BR vs C8-TA group. After T. gondii tachyzoites infected astrocytes, DEPs were enriched in immune-related biological processes to promote the formation of bradyzoites and maintain the balance of T. gondii, CNS and brain. After T. gondii bradyzoites infected astrocytes, the DEPs up-regulated the host's glucose metabolism, and some up-regulated DEPs were closely related to neurodegenerative diseases. These findings not only provide new insights into the psychiatric pathogenesis of T. gondii, but also provide potential targets for the treatment of acute and chronic Toxoplasmosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Label-free quantitative proteomics analyses of mouse astrocytes provides insight into the host response mechanism at different developmental stages ofToxoplasma gondii

Xie

Zhao

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…[76]. Liver fibrosis was also observed in SIRT2 KO mice, suggesting a role for this deacetylase in preventing profibrotic molecular pathways [88]. SIRT6 can also prevent liver fibrosis by deacetylating SMAD2/3, an event that is prevented by the accumulation of the pro-fibrotic protein, S100A11 [89].…”

Section: Fibrosismentioning

confidence: 99%

Sirtuins and Hypoxia in EMT Control

et al. 2022

View full text Add to dashboard Cite

Epithelial–mesenchymal transition (EMT), a physiological process during embryogenesis, can become pathological in the presence of different driving forces. Reduced oxygen tension or hypoxia is one of these forces, triggering a large number of molecular pathways with aberrant EMT induction, resulting in cancer and fibrosis onset. Both hypoxia-induced factors, HIF-1α and HIF-2α, act as master transcription factors implicated in EMT. On the other hand, hypoxia-dependent HIF-independent EMT has also been described. Recently, a new class of seven proteins with deacylase activity, called sirtuins, have been implicated in the control of both hypoxia responses, HIF-1α and HIF-2α activation, as well as EMT induction. Intriguingly, different sirtuins have different effects on hypoxia and EMT, acting as either activators or inhibitors, depending on the tissue and cell type. Interestingly, sirtuins and HIF can be activated or inhibited with natural or synthetic molecules. Moreover, recent studies have shown that these natural or synthetic molecules can be better conveyed using nanoparticles, representing a valid strategy for EMT modulation. The following review, by detailing the aspects listed above, summarizes the interplay between hypoxia, sirtuins, and EMT, as well as the possible strategies to modulate them by using a nanoparticle-based approach.

show abstract

“…Previous studies have shown that SIRT2 is involved in lipid synthesis by affecting the nuclear translocation of FOXO1, which inhibits the transcription of PPAR γ [ 39 ]. SIRT2 can also inhibit lipid synthesis by downregulating FOXO1 [ 52 ]. However, a recent study by Akbulut et al showed that decreased FOXO1 levels were related to lipid peroxidation and increased SIRT2 expression levels [ 53 ].…”

Section: Role Of Sirt2 In Signal Transductionmentioning

confidence: 99%

Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal Transduction

et al. 2022

View full text Add to dashboard Cite

Sirtuin 2 (SIRT2), as a member of the sirtuin family, has representative features of evolutionarily highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase activity. In addition, SIRT2, as the only sirtuin protein colocalized with tubulin in the cytoplasm, has its own functions and characteristics. In recent years, studies have increasingly shown that SIRT2 can participate in the regulation of gene expression and regulate signal transduction in the metabolic pathway mainly through its post-translational modification of target genes; thus, SIRT2 has become a key centre in the metabolic pathway and participates in the pathological process of metabolic disorder-related diseases. In this paper, it is discussed that SIRT2 can regulate all aspects of gene expression, including epigenetic modification, replication, transcription and translation, and post-translational modification, which enables SIRT2 to participate in energy metabolism in life activities, and it is clarified that SIRT2 is involved in metabolic process-specific signal transduction mechanisms. Therefore, SIRT2 can be involved in metabolic disorder-related inflammation and oxidative stress, thereby triggering the occurrence of metabolic disorder-related diseases, such as neurodegenerative diseases, tumours, diabetes, and cardiovascular diseases. Currently, although the role of SIRT2 in some diseases is still controversial, given the multiple roles of SIRT2 in regulating physiological and pathological signal transduction, SIRT2 has become a key target for disease treatment. It is believed that with increasing research, the clinical application of SIRT2 will be promoted.

show abstract

The role of Sirtuin 2 in sustaining functional integrity of the liver

Cited by 16 publications

References 36 publications

Label-free quantitative proteomics analyses of mouse astrocytes provides insight into the host response mechanism at different developmental stages ofToxoplasma gondii

Label-free quantitative proteomics analyses of mouse astrocytes provides insight into the host response mechanism at different developmental stages ofToxoplasma gondii

Sirtuins and Hypoxia in EMT Control

Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal Transduction

Contact Info

Product

Resources

About