The role of socioeconomic status in the susceptibility to develop systemic lupus erythematosus in Mexican patients

Salgado-Galicia, Norma; Hernández-Doño, Susana; Gómez, Daniela Ruiz; Jakez‐Ocampo, Juan; Zúñiga, Joaquı́n; Vargas‐Alarcón, Gilberto; Acuña, Víctor; Hernández, María Cristina; Márquez-García, José Eduardo; García-Lechuga, Maricela; Llórente, Luis; Lima, Guadalupe; Pineda, Carlos; Yu, Neng; Yunis, Edmond J.; Granados, Julio

doi:10.1007/s10067-020-04928-5

Cited by 8 publications

(4 citation statements)

References 37 publications

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“…HLA-DRB1 ∗ 14:06∼DQB1 ∗ 03:01 and -DRB1 ∗ 16:02∼DQB1 ∗ 03:01 the protective Mexican Native American haplotypes which frequency is diminished in SLE patients from Mexico City, as it is shown in previous studies ( Salgado-Galicia et al, 2020 ) and the current one. The HLA-DRB1 ∗ 14 has been previously found in Asians as -DRB1 ∗ 14:03 ( Furukawa et al, 2014 ).…”

Section: Resultssupporting

confidence: 83%

“…In Mexico, susceptibility varies as the ethnic admixture does, the admixture in Mexico is very heterogeneous across the Country, contributing to the disease variability ( Moreno-Estrada et al, 2014 ; Barquera et al, 2020b ). Therefore, the admixture diversity has contributed to the enrichment of susceptibility markers and an ample SLE phenotypes specter in Mexicans ( Salgado-Galicia et al, 2020 ). For instance, the most common susceptibility allele, HLA-DRB1 ∗ 03:01, previously identified in Mexico City, was not found in Tapachula Chiapas SLE patients.…”

Section: Introductionmentioning

confidence: 99%

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Heterogeneity of Genetic Admixture Determines SLE Susceptibility in Mexican

et al. 2021

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Systemic Lupus Erythematosus (SLE) is an autoimmune inflammatory disorder for which Major Histocompatibility Complex (MHC) genes are well identified as risk factors. SLE patients present different clinical phenotypes, which are partly explained by admixture patterns variation among Mexicans. Population genetic has insight into the high genetic variability of Mexicans, mainly described through HLA gene studies with anthropological and biomedical importance. A prospective, case-control study was performed. In this study, we recruited 146 SLE patients, and 234 healthy individuals were included as a control group; both groups were admixed Mexicans from Mexico City. The HLA typing methods were based on Next Generation Sequencing and Sequence-Based Typing (SBT). The data analysis was performed with population genetic programs and statistical packages. The admixture estimations based on HLA-B and -DRB1 revealed that SLE patients have a higher Southwestern European ancestry proportion (48 ± 8%) than healthy individuals (30 ± 7%). In contrast, Mexican Native American components are diminished in SLE patients (44 ± 1%) and augmented in Healthy individuals (63 ± 4%). HLA alleles and haplotypes’ frequency analysis found variants previously described in SLE patients from Mexico City. Moreover, a conserved extended haplotype that confers risk to develop SLE was found, the HLA-A∗29:02∼C∗16:01∼B∗44:03∼DRB1∗07:01∼DQB1∗02:02, pC = 0.02, OR = 1.41. Consistent with the admixture estimations, the origin of all risk alleles and haplotypes found in this study are European, while the protection alleles are Mexican Native American. The analysis of genetic distances supported that the SLE patient group is closer to the Southwestern European parental populace and farthest from Mexican Native Americans than healthy individuals. Heterogeneity of genetic admixture determines SLE susceptibility and protection in Mexicans. HLA sequencing is helpful to determine susceptibility alleles and haplotypes restricted to some populations.

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Section: Resultssupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Heterogeneity of Genetic Admixture Determines SLE Susceptibility in Mexican

et al. 2021

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“…The highest incidence has been reported in North America, while countries in sub-Saharan Africa, Europe, and Australia have a lower incidence. These differences have been attributed to different genetic predisposition [ 7 ], and socioeconomic [ 8 ] and environmental factors [ 9 ]. Women of reproductive age are more prone to SLE than males, with the incidence ratio between females and males varying between 8:1 and 15:1 [ 9 ].…”

Section: Epidemiologymentioning

confidence: 99%

Advances in the Pathogenesis and Treatment of Systemic Lupus Erythematosus

Accapezzato

Caccavale

Paroli

et al. 2023

IJMS

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Systemic lupus erythematosus (SLE) is a genetically predisposed, female-predominant disease, characterized by multiple organ damage, that in its most severe forms can be life-threatening. The pathogenesis of SLE is complex and involves cells of both innate and adaptive immunity. The distinguishing feature of SLE is the production of autoantibodies, with the formation of immune complexes that precipitate at the vascular level, causing organ damage. Although progress in understanding the pathogenesis of SLE has been slower than in other rheumatic diseases, new knowledge has recently led to the development of effective targeted therapies, that hold out hope for personalized therapy. However, the new drugs available to date are still an adjunct to conventional therapy, which is known to be toxic in the short and long term. The purpose of this review is to summarize recent advances in understanding the pathogenesis of the disease and discuss the results obtained from the use of new targeted drugs, with a look at future therapies that may be used in the absence of the current standard of care or may even cure this serious systemic autoimmune disease.

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“…Another consequence of confinement is that it highlights the existing inequality, based on misogynistic stereotypes, in the distribution of unpaid labor (i.e. household chores and care) (Salgado-Galicia et al 2020 ). This inequality was normalized when authorities stated that women at home would have no issue looking after the health of elders, affirming that men tend to be “more detached” (Morales, Miranda, and Villa y Caña 2020 ).…”

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confidence: 99%

The COVID-19 Pandemic and Ethics in Mexico Through a Gender Lens

Lara

Arellano

2020

Bioethical Inquiry

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In Mexico, significant ethical and social issues have been raised by the COVID-19 pandemic. Some of the most pressing issues are the extent of restrictive measures, the reciprocal duties to healthcare workers, the allocation of scarce resources, and the need for research. While policy and ethical frameworks are being developed to face these problems, the gender perspective has been largely overlooked in most of the issues at stake. Domestic violence is the most prevalent form of violence against women, which can be exacerbated during a pandemic: stress and economic uncertainty are triggers for abuse, and confinement limits access to support networks. Confinement also exacerbates the unfair distribution of unpaid labor, which is disproportionately assigned to women and girls, and highlights inequality in the overall labor market. Lack of security measures has resulted in attacks towards health workers, particularly female nurses, due to fear of contamination. Finally, resource results in lack of access to other health necessities, including sexual and reproductive health services. Research across all disciplines to face-and to learn from-this crisis should be done through a gender lens, because understanding the realities of women is essential to understand the pandemic's true effects in Mexico and the world.

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The role of socioeconomic status in the susceptibility to develop systemic lupus erythematosus in Mexican patients

Cited by 8 publications

References 37 publications

Heterogeneity of Genetic Admixture Determines SLE Susceptibility in Mexican

Heterogeneity of Genetic Admixture Determines SLE Susceptibility in Mexican

Advances in the Pathogenesis and Treatment of Systemic Lupus Erythematosus

The COVID-19 Pandemic and Ethics in Mexico Through a Gender Lens

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